Comparison of myocardial function in children with body mass indexes ≥25 versus those &lt;25 kg/m2

Mehta, Sudhir; Holliday, Cindy; Hayduk, Louisa; Wiersma, Linda; Richards, Nancy; Younoszai, Adel K.

doi:10.1016/j.amjcard.2004.03.016

Cited by 60 publications

(54 citation statements)

References 10 publications

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“…Nevertheless, subtle alterations in myocardial function can be detected. No differences are detected in LV shortening fraction or ejection fraction between overweight/obese children compared with normal weight controls [93]. However, impaired left ventricular relaxation was noted in relation to BMI [93].…”

Section: Systolic Functionmentioning

confidence: 83%

“…No differences are detected in LV shortening fraction or ejection fraction between overweight/obese children compared with normal weight controls [93]. However, impaired left ventricular relaxation was noted in relation to BMI [93]. In a small study of ten obese adolescents, left ventricular end-diastolic and stroke volumes were 7.8 and 14.5 % lower in the obese children compared with lean controls [94].…”

Section: Systolic Functionmentioning

confidence: 86%

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Cardiac Abnormalities in Youth with Obesity and Type 2 Diabetes

Bacha

Gidding

2016

Curr Diab Rep

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Childhood obesity has been linked to cardiovascular disease (CVD) risk in adulthood. Of great concern is the expected increase in the population's CVD burden in relation to childhood obesity. This is compounded by the risk related to chronic hyperglycemia exposure in youth with type 2 diabetes. We herein provide an overview of the spectrum of early cardiovascular disease manifestation in youth with obesity and type 2 diabetes, in particular abnormalities in cardiac structure and function. Cardiac remodeling and adverse target organ damage is already evident in the pediatric age group in children with obesity and type 2 diabetes. This supports the importance of intensifying obesity prevention efforts and early intervention to treat comorbidities of obesity in the pediatric age group to prevent cardiac events in early adulthood.

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Section: Systolic Functionmentioning

confidence: 83%

Section: Systolic Functionmentioning

confidence: 86%

Cardiac Abnormalities in Youth with Obesity and Type 2 Diabetes

Bacha

Gidding

2016

Curr Diab Rep

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“…Conventional Doppler studies may fail to show diastolic dysfunctions. Thereby, tissue Doppler imaging may detect early diastolic dysfunctions even when conventional Doppler findings are normal in the patients (19).…”

Section: Variablesmentioning

confidence: 99%

Factors associated with left atrial size in obese children: an observational study

Özdemir¹,

Abacı²,

Hızlı³

et al. 2011

Anadolu Kardiyol Derg

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ÖZETAmaç: Sol atriyal boyutun kalp-damar hastalıkları için bağımsız bir risk faktörü olduğu kabul edilmektedir. Sol atriyum ölçümleri kalp-damar hastalıklarının önemli bir risk faktörü olan obeziteyi değerlendirmede kullanılabilir. Bu çalışmada, hipertansiyonu olmayan obez çocuklarda, kardiyak risk belirteci olan sol atriyal boyutu etkileyen faktörlerin belirlenmesi amaçlanmıştır. Yöntemler: Bu enine-kesitsel gözlemsel çalışma Çocuk Kardiyolojisi Kliniğinde Nisan 2008 ile Eylül 2009 arasında yapılmıştır. Seksen obez çocuk ve 82 normal vücut ağırlıklı çocuk çalışmaya alınmıştır. Obezite tanısı, Dünya Sağlık Örgütü sınıflamasında tanımlanan, vücut kitle indeksi standart sapma skorunun aynı cinsiyet ve yaş için olanının + 2 standart sapma üzerinde olması şeklinde tanımlanmıştır. Bütün çocuklara iki-boyutlu, M-mod ve Doppler ekokardiyografi çalışmaları yapılmıştır. Olguların karşılaştırılmasında, grup oran farklılıklarında, sol atriyal boyut ile ilişkili değişkenlerin değerlendirilmesinde ve bağımsız değişkenlerin etkilerinin araştırılmasında sırasıyla Student's t-testi, Ki-kare testi, Pearson korelasyon analizi ve çoklu regresyon analizi kullanılmıştır. Bulgular: Obez hastaların ortalama yaşı 11.7±2.2 yıl ve normal çocukların ortalama yaşı 11.7±2.2 yıl olarak belirlendi. Obez çocuklarda, vücut ağırlığı, vücut kitle indeksi, vücut kitle indeksi standart sapma skoru, bel çevresi, sistolik ve diyastolik kan basıncı, açlık insülini ile insülin direnci istatistiksel olarak artmış bulundu (p<0.05). Sol atriyal boyutun, yaş (r=0.523), vücut kitle indeksi (r=0.394), bel çevresi (r=0.421), diyastolik kan basıncı (r=0.230), insülin direnci (r=0.350) ve sol ventrikül kütlesi (r=0.535) ile istatistiksel olarak ilişkisi de saptandı (p<0.05). Çoklu regresyon ABSTRACTObjective: Left atrial size can be considered an independent risk factor for cardiovascular diseases. The measurements of left atrium may be used to assess obesity, which is an important risk factor of cardiovascular diseases. It is aimed to determine the factors that effect to the left atrial size, which is an indicator of cardiac risk in obese children without hypertension. Methods: The cross-sectional observational study was performed between April 2008 and September 2009 at the clinic of Pediatric Cardiology. Eighty obese and 82 lean children were studied. Diagnosis of obesity was defined according to the World Health Organization classification as the standard deviation score of body mass index being over + 2 standard deviation of the same gender and age. All subjects underwent twodimensional, M-mode, and Doppler echocardiographic studies. Student's t-test, Chi-square test, Pearson correlation analysis, and multiple stepwise regression analyses were used to compare the subjects, differences in group proportions, evaluate the relation of variables with the left atrial size, and examine the effects of significant independent variables, respectively. Results: The mean age of obese patients was 11.7±2.2 years and it of lean subjects was 11.7±2.2 years. Body weight, ...

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“…Como a obesidade pode acarretar remodelação cardíaca, (12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(25)(26)(27)(28)(29)(30)(31)(32)(33)(35)(36)(37)(38)(39) o coração foi analisado por meio de estudos estruturais e funcionais. A estrutura foi avaliada post mortem por análises macroscópicas.…”

Section: 9-caracterização Da Remodelação Cardíacaunclassified

“…Estudos clínicos mostram que obesidade está associada a disfunção ventricular, geralmente, diastólica (12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22) , e não consistente comprometimento do desempenho sistólico (3,12,13,16,18,19,(22)(23)(24) . Pesquisas em animais geneticamente obesos mostram, na sua maioria, disfunção contrátil e de relaxamento cardíaco (25)(26)(27)(28)(29)(30)(31)(32)(33) .…”

Section: Introductionunclassified

Influência da oxidação de glicose sobre a função miocárdica de ratos obesos

Campos¹

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EPÍGRAFE ´1HQKXP YHQWR VRSUD D IDYRU GH TXHP QmR VDEH SDUD RQGH LUµ 6rQHFD RESUMOObesidade é uma doença metabólica crônica definida pelo acúmulo excessivo do tecido adiposo em relação à massa magra tecidual. Estudos clínicos mostram que a obesidade está associada à disfunção ventricular diastólica e não consistente comprometimento do desempenho sistólico. Os modelos experimentais que induzem obesidade por dietas têm sido utilizados como alternativa para se estudar as conseqüências das anormalidades cardíacas decorrentes do acúmulo de gordura.Pesquisas mostram que a função cardíaca em animais obesos pode estar preservada, diminuída ou aumentada. Alterações nos substratos energéticos, inibição da via glicolítica pelos ácidos graxos e redução na atividade da enzima piruvato desidrogenase (PDH) podem contribuir para a disfunção cardíaca induzida pela obesidade. Em razão da ausência de pesquisas que avaliaram a relação entre função cardíaca e metabolismo energético na obesidade, o objetivo deste estudo foi testar a hipótese que o desequilíbrio energético miocárdico, entre ácidos graxos e glicose, ocasionado pela obesidade, acarreta disfunção cardíaca. O prejuízo funcional nos animais obesos é decorrente de déficit de adenosina trifosfato (ATP), via glicolítica, para a bomba de cálcio (Ca 2+ ) do retículo sarcoplasmático (SERCA2). Wistar rats were assigned to one of two groups (n=30 each): control (C) and obese (Ob). The C group was fed a standard diet and Ob group was fed cycles of four highfat diets for 30 weeks. The total body fat was measured from the sum of the individual fat pad weights (epididymal, retroperitoneal and visceral) and the obesity defined by adiposity index. The nutritional and metabolic profiles of these animals were also evaluated. The cardiac remodeling process was assessed by structural and functional analysis. The structure was analyzed post-death for macroscopic study.Myocardial performance of isolated papillary muscle from the left ventricle (LV) was evaluated by under baseline conditions and after inotropic maneuvers. Comparisons between experimental groups (control and obese rats) were performed using Students-t test for independent samples. The cardiac function, after inotropic maneuvers, was analyzed by two-way analysis of variance (ANOVA) for repeated measures and complemented by Student-Newman-Keuls's posthoc test for specific differences. The level of significance considered was 5 %. Obesity promoted glucose intolerance, hyperinsulinemia, hyperleptinemia and insulin resistance after 30 weeks.However, the behavior of systolic blood pressure was similar between groups. The post-death macroscopic study showed that obesity doesn't promote to an increase in heart weight and heart chambers at 30 weeks. Obesity did not cause myocardial stiffness and damage on cardiac function under baseline conditions. Several inotropic maneuvers no make evident changes between control and obese, since the behavior of developed tension (DT) was similar between the groups. The return values of DT and resting ...

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Comparison of myocardial function in children with body mass indexes ≥25 versus those <25 kg/m2

Cited by 60 publications

References 10 publications

Cardiac Abnormalities in Youth with Obesity and Type 2 Diabetes

Cardiac Abnormalities in Youth with Obesity and Type 2 Diabetes

Factors associated with left atrial size in obese children: an observational study

Influência da oxidação de glicose sobre a função miocárdica de ratos obesos

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