Comparison of myocardial damage among dogs at different stages of clinical leishmaniasis and dogs with idiopathic chronic kidney disease

Martínez-Hernández, Lucía; Casamian‐Sorrosal, Domingo; Barrera-Chacón, Rafael; Cuesta-Gerveno, J.M.; Belinchón-Lorenzo, Silvia; Nieto, Luis Carlos Gómez; Duque, Javier

doi:10.1016/j.tvjl.2016.11.015

Cited by 14 publications

(30 citation statements)

References 19 publications

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“…Associations between the degree of azotaemia and serum troponin have been investigated repeatedly with conflicting results, 7,14 with most studies failing to show a significant correlation. A weak correlation, as detected in the present study, might support the idea that haemodynamic changes and uraemic toxins lead to secondary myocardial injury, worsening with more severe renal dysfunction.…”

Section: Discussionmentioning

confidence: 99%

Cardiac troponin I in cats with compromised renal function

Langhorn

Jessen

Kloster

et al. 2018

Journal of Feline Medicine and Surgery

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Objectives Cardiac troponins are sensitive and specific markers of myocardial injury. However, their reliability in renal disease has been questioned owing to possible renal involvement in troponin elimination. The primary objective of the present study was to examine whether serum cardiac troponin I is elevated in cats with compromised renal function and no clinically relevant structural cardiac disease. A secondary objective was to examine whether cardiac troponin I is measurable in the urine of cats with normal and compromised renal function. Methods This prospective case-control study included 52 cats (19 with compromised renal function, 19 with primary cardiac disease and 14 healthy controls). For all cats, clinical examination, echocardiography, electrocardiography, blood pressure, complete blood count, biochemistry, serum thyroxine and urinalysis were performed. Cardiac troponin I was measured in the serum and urine of each cat. Results Median (range) serum cardiac troponin I concentrations were 0.052 ng/ml (0.015–0.78 ng/ml) for the renal group, 0.083 ng/ml (0.003–3.27 ng/ml) for the cardiac group and 0.012 ng/ml (0.003–0.14 ng/ml) for the control group. The renal and cardiac groups both had significantly higher serum cardiac troponin I concentrations than the control group, whereas no difference could be detected between the renal and cardiac groups. In the renal group 7/19 cats had measurable urine cardiac troponin I, whereas cardiac troponin I was measurable in the urine of one cat in the cardiac group and two healthy controls. There was no significant correlation between serum and urine cardiac troponin I. Conclusions and relevance Elevated serum cardiac troponin I in cats with compromised renal function may occur without evidence of clinically relevant structural cardiac disease. Moreover, detecting cardiac troponin I in urine is most likely in cats with compromised renal function.

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Section: Discussionmentioning

confidence: 99%

Cardiac troponin I in cats with compromised renal function

Langhorn

Jessen

Kloster

et al. 2018

Journal of Feline Medicine and Surgery

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“…Some dogs with leishmaniosis can have an impairment of renal perfusion secondary to hypovolemia or severe dehydration which would lead to an increase in SDMA concentration not associated with proteinuria or renal azotemia. Vasculitis of renal arterioles [ 37 , 38 ] and myocarditis [ 38 – 41 ] have also been described in dogs with leishmaniosis and should be taken into account as less probable causes of decreased GFR. We suggest that dogs with leishmaniosis and moderate to high increases in SDMA concentrations without proteinuria should be carefully evaluated for other diseases or pathogenic mechanisms which could lead to prerenal impairment of renal perfusion.…”

Section: Discussionmentioning

confidence: 99%

Serum Symmetric Dimethylarginine as an Early Marker of Excretory Dysfunction in Canine Leishmaniosis(L. infantum)Induced Nephropathy

Torrent

Planellas

Ordeix

et al. 2018

Veterinary Medicine International

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The aims of the study were to determine whether symmetric dimethylarginine (SDMA) was increased in dogs with leishmaniosis and to assess its relationship with creatinine concentration and urinary protein : creatinine ratio (UPC) to determine its utility as a marker of early excretory dysfunction. Fifty-three dogs with leishmaniosis classified according to the LeishVet clinical staging (stage I, n = 5, stage II, n = 30; stage III, n = 12; stage IV, n = 6) were selected and compared with 41 clinically healthy dogs. Thirty-nine dogs with leishmaniosis were also followed up for six months. SDMA concentrations on the day of diagnosis were significantly higher in dogs with leishmaniosis with respect to control dogs and in dogs from LeishVet stage IV when compared with the other stages. Increased UPC (>0.5), SDMA (>19 μg/dL), and creatinine concentrations (≥1.4 mg/dL) were found in 47.1%, 15.1%, and 9.4% of dogs with leishmaniosis, respectively. SDMA concentration was increased in 24% of proteinuric dogs, in 7% of nonproteinuric dogs, and in four of five dogs with increased creatinine. SDMA concentration ≥ 25 μg/dL was associated with clinical chronic kidney disease (CKD) after six months. Our results did not demonstrate advantages in using SDMA concentration as an early marker of CKD when compared to creatinine and UPC in canine leishmaniosis.

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“…6 Moreover, this marker has been shown to be altered at earlier stages of the disease before creatinine is elevated. 5 NT-proBNP is a cardiac stress marker which is elevated both in cardiac 7 and renal 8 disease and could also therefore be a potential good biomarker in CanL. It might potentially be added to other markers for disease classification and therapy and research purposes.…”

Section: Introductionmentioning

confidence: 99%

Comparison of N‐terminal proB‐type natriuretic peptide levels at different stages of visceral leishmaniosis and in patients with chronic kidney disease

et al. 2019

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N-terminal proB-type natriuretic peptide (NT-proBNP) may be a useful marker in canine leishmaniosis (CanL). The aim was to compare NT-proBNP in dogs at different LeishVet stages of CanL and with idiopathic chronic kidney disease (CKD). Dogs diagnosed with CanL or CKD and a group of healthy dogs were included (group A, five normal dogs; group B, six dogs LeishVet 1–2; group C, 13 dogs LeishVet 3–4; group D, six dogs with CKD). NT-proBNP was higher (P<0.001) in group C (7.616 pmol/l, interquartile range (IQR) 3537–10,000 pmol/l) than in group A (293 pmol/l, IQR 257–373), group B (388.5 pmol/l, IQR 324–793) and group D (740 pmol/l, IQR 557–962 pmol/l). International Renal Interest Society (IRIS) kidney stage was not different between groups C and D or between groups A and B, but was different within all the rest of the group comparisons (P<0.001). In group C all dogs had echocardiographic increase in left ventricular mass index. NT-proBNP had negative correlation with haematocrit (P<0.001, r=0.749) and positive correlation with systemic blood pressure (P<0.001, r=0.728). NT-proBNP is consistently elevated in dogs with advanced CanL and is strongly correlated with the degree of systemic hypertension and anaemia. Moreover, dogs with advanced CanL exhibit increase in left ventricular mass. NT-proBNP may however be a less desirable cardiac marker as unlike cardiac troponin I it is often not elevated at earlier stages of CanL.

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Comparison of myocardial damage among dogs at different stages of clinical leishmaniasis and dogs with idiopathic chronic kidney disease

Cited by 14 publications

References 19 publications

Cardiac troponin I in cats with compromised renal function

Cardiac troponin I in cats with compromised renal function

Serum Symmetric Dimethylarginine as an Early Marker of Excretory Dysfunction in Canine Leishmaniosis(L. infantum)Induced Nephropathy

Comparison of N‐terminal proB‐type natriuretic peptide levels at different stages of visceral leishmaniosis and in patients with chronic kidney disease

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