Comparison of myocardial blood flow during dobutamine-atropine infusion with that after dipyridamole administration in normal men

Tadamura, Eiji; Iida, Hidehiro; Matsumoto, Keīichi; Mamede, Marcelo; Kubo, Shigeto; Toyoda, Hiroshi; Shiozaki, Toshiki; Mukai, Takahiro; Magata, Yasuhiro; Konishi, Junji

doi:10.1016/s0735-1097(00)01043-3

Cited by 56 publications

(29 citation statements)

References 31 publications

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“…There is no advantage to using modified protocols such as high-dose dipyridamole or hand grip (attenuated hyperemic MBF) during dipyridamole stress and MBF imaging with PET. 38 If vasodilator stress is contraindicated, dobutamine combined with atropine stress is an alternate and provides maximal hyperemia equivalent to that with dipyridamole, [39][40][41] although there are some data indicating the contrary. [42][43][44] Hyperemia from pharmacologic stress may be reversed for significant ischemic electrocardiography changes or symptoms about 3-4 minute after the start of imaging, without jeopardizing quantitative MBF information.…”

Section: Stress Test Proceduresmentioning

confidence: 99%

Clinical Quantification of Myocardial Blood Flow Using PET: Joint Position Paper of the SNMMI Cardiovascular Council and the ASNC

Murthy

Bateman²,

Beanlands

et al. 2018

Journal of Nuclear Cardiology

172

111

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Section: Stress Test Proceduresmentioning

confidence: 99%

Clinical Quantification of Myocardial Blood Flow Using PET: Joint Position Paper of the SNMMI Cardiovascular Council and the ASNC

Murthy

Bateman²,

Beanlands

et al. 2018

Journal of Nuclear Cardiology

172

111

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“…A 10-min transmission scan using 2 rotating 68 Ge pin sources was obtained for the attenuation correction. The spatial resolution of the reconstructed clinical PET images is ;8-mm full width at half maximum at the center of the field of view, and the axial resolution is ;4 mm (20).…”

Section: Imaging Protocolsmentioning

confidence: 99%

Comparison of Contrast-Enhanced MRI with 18F-FDG PET/201Tl SPECT in Dysfunctional Myocardium: Relation to Early Functional Outcome After Surgical Revascularization in Chronic Ischemic Heart Disease

Wu¹,

Tadamura²,

Yamamuro³

et al. 2007

Journal of Nuclear Medicine

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Revascularization of viable myocardial segments has been shown to improve left ventricular (LV) function and long-term prognosis; however, the surgical risk is comparatively higher in patients with a low ejection fraction (EF). We compared contrastenhanced MRI with 18 F-FDG PET/ 201 Tl SPECT for myocardial viability and prediction of early functional outcome in patients with chronic coronary artery disease (CAD). Methods: Forty-one patients with chronic CAD and LV dysfunction (mean age 6 SD, 66 6 10 y; 32 men; mean EF 6 SD, 38% 6 13%) referred for 18 F-FDG PET, 201 Tl-SPECT and MRI within 2 wk were included. Twenty-nine subjects underwent coronary artery bypass grafting (CABG), and LV function was reassessed by MRI before discharge (17 6 7 d after surgery). Two were excluded from outcome analysis (1 death due to sepsis; 1 perioperative myocardial infarction). The extent of viable myocardium by 18 F-FDG PET/ 201 Tl SPECT was defined by the metabolism-perfusion mismatch or ischemia, in comparison with the extent of delayed enhancement (DE) on MRI in a 17-segment model. Segmental functional recovery was defined as improvement in the wall motion score of $1 on a 4-point scale. EF and LV volume change were used as global functional outcome. Results: Three hundred ninety-four dysfunctional segments were compared, and the extent of DE on MRI correlated negatively with the viability on 18 F-FDG PET. Of 252 dysfunctional segments that were successfully revascularized, the sensitivity, specificity, positive predictive value, and negative predictive value of PET/SPECT were 60.2%, 98.7%, 76.6%, and 96.7% and of MRI were 92.2%, 44.9%, 72.4%, and 78.6% using the cutoff value of 50% DE on MRI, without significant differences in overall accuracies. In 18 subjects who underwent isolated CABG, improvement of EF ($5%) and reverse LV remodeling ($10% LV size reduction) was best predicted by the no DE on MRI, and patients with substantial nonviable myocardium on 18 F-FDG/SPECT predicted a poor early functional outcome (all P , 0.001). Conclusion: Accurate prediction of early functional outcome by PET/SPECT and contrast-enhanced MRI is possible.

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“…35,36 The MFR in the septum was lower than that in the free wall in patients with DHCM, but this difference did not achieve Rest ATP …”

Section: Patients' Clinical and Functional Characteristicsmentioning

confidence: 99%

“…The spatial resolution of the reconstructed clinical PET images was ~8 mm in full-width half-maximum at the center of the field of view, and the axial resolution was ~4 mm. 36 The subjects lay supine in the PET scanner with their arms out of the field of view. A 10-min transmission scan using 2 rotating 68 Ge pin sources made the attenuation correction.…”

Section: Study Protocolmentioning

confidence: 99%

Difference in Myocardial Flow Reserve Between Patients With Dilated Cardiomyopathy and Those With Dilated Phase of Hypertrophic Cardiomyopathy Evaluation by 15O-Water PET

Ohba

Hosokawa

Kambara

et al. 2007

Circ J

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yocardial flow reserve (MFR) is defined as the ratio of maximal to basal myocardial blood flow (MBF), and it is related to the severity of coronary artery stenosis. [1][2][3][4][5][6][7][8] Therefore, the MFR value is clinically useful for decision-making and the strategy of coronary intervention. Recent studies have shown that MFR is impaired by age 9 and coronary risk factors, such as smoking, 10 hyperlipidemia (HPL), 11,12 diabetes mellitus (DM), 13 and hypertension (HTN), 14 even in the absence of coronary stenosis. The MFR can be accurately measured invasively and noninvasively. Clinical evaluation of MFR using positron emission tomography (PET) is a safe and repeatable method to use for patients without coronary artery disease, 15-17 compared with invasive methods such as Doppler flow-wire. 18 Several studies have reported that MFR is impaired, together with the poor prognosis, in both patients with dilated cardiomyopathy (DCM) [19][20][21][22][23][24] and those with hypertrophic cardiomyopathy (HCM). [25][26][27][28][29][30] In particular, the prognosis is poorer for patients with the dilated phase of HCM (DHCM), who have systolic dysfunction and left ventricular (LV) remodeling, than in those with DCM. However, the pathophysiological differences between these 2 types of cardiomyopathies remain unclear. The purpose of this study was to compare MBF, MFR and coronary vascular resistance (CVR) between patients with DCM and those with DHCM, using 15 O-labeled water PET,8,[31][32][33] which is similar to 13 N ammonia PET. 34 Methods Study PopulationWe studied 30 patients with cardiomyopathies (23 men, 7 women; mean age 60.9±12.3 years) who were admitted to the Department of Cardiovascular Medicine, Kyoto University Hospital because of worsening heart failure. The group included 23 patients with DCM (Group A) and 7 patients with DHCM (Group B). After admission, the patients were treated with conventional medical therapy, and Circ J 2007; 71: 884 -890 (Received October 10, 2006; revised manuscript received January 24, 2007; accepted February 26, 2007 (MFR) is impaired in patients with nonischemic cardiomyopathy, and the reduced MFR may be related to poor prognosis. Several studies report that the mortality rate for patients with DHCM is higher than for DCM, but the difference between these 2 cardiomyopathies is still unclear. The purpose of this study was to assess the MFR of these 2 cardiomyopathies, using 15 O-water positron emission tomography (PET) to elucidate their differences. Methods and ResultsIn total 30 patients were investigated: 23 with DCM (Group A) and 7 with DHCM (Group B). All those who were in a stable condition underwent cardiac catheterization. Myocardial blood flow (MBF) at rest and under ATP infusion was measured by 15 O-water PET, and the MFR was calculated. There were no significant differences in the hemodynamics of the 2 groups. The mean MFR in DHCM was significantly lower than that in DCM (1.49±0.31 vs 2.62±1.08; p=0.042), whereas MBF at rest did not differ (DCM vs DHCM: 0.66±0.20 ...

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Comparison of myocardial blood flow during dobutamine-atropine infusion with that after dipyridamole administration in normal men

Abstract: Near maximal coronary vasodilatation caused by dipyridamole is attainable using dobutamine and atropine in young healthy volunteers. Dobutamine in conjunction with atropine is no less effective than dipyridamole in producing myocardial hyperemia.

Cited by 56 publications

References 31 publications

Clinical Quantification of Myocardial Blood Flow Using PET: Joint Position Paper of the SNMMI Cardiovascular Council and the ASNC

Clinical Quantification of Myocardial Blood Flow Using PET: Joint Position Paper of the SNMMI Cardiovascular Council and the ASNC

Comparison of Contrast-Enhanced MRI with 18F-FDG PET/201Tl SPECT in Dysfunctional Myocardium: Relation to Early Functional Outcome After Surgical Revascularization in Chronic Ischemic Heart Disease

Difference in Myocardial Flow Reserve Between Patients With Dilated Cardiomyopathy and Those With Dilated Phase of Hypertrophic Cardiomyopathy Evaluation by 15O-Water PET

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