Comparison of Myelodysplastic Syndrome Prognostic Scoring Systems

Bektas, Ozlen; Üner, Ayşegül; Eliaçık, Eylem; Uz, Burak; Işık, Aynur; Etgül, Sezgin; Bozkurt, Süreyya; Haznedaroğlu, İbrahim C.; Göker, Hakan; Sayınalp, Nilgün; Aksu, Salih; Demiroǧlu, Halûk; Özcebe, Osman; Büyükaşık, Yahya

doi:10.4274/tjh.2014.0455

Cited by 4 publications

(5 citation statements)

References 17 publications

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“…It is also worth mentioning, Bektaş et al. ( 36 ) pointed out that both WPSS and IPSS-R were superior predictors for OS in MDS patients, with WPSS being more effective in predicting LFS. At present, the IPSS-R system is widely used.…”

Section: Discussionmentioning

confidence: 97%

The Prognostic Value of Pretherapy Peripheral Blood Inflammatory Indices in Myelodysplastic Syndromes

et al. 2022

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BackgroundInflammation appears to have a critical role in carcinogenesis tumor growth according to emerging research. The platelet-to-lymphocyte ratio (PLR), neutrophil-to-lymphocyte ratio (NLR), and plasma C-reactive protein (CRP) are considered to reflect the systemic inflammatory response and clinical prognosis. The prognostic value of inflammatory indices in myelodysplastic syndrome (MDS) patients remains unclear.MethodsA total of 213 MDS patients were enrolled for the study. Univariate and multivariate analyses were performed to determine the prognostic significance of various indicators, including PLR, NLR, and CRP.ResultsMDS patients with higher PLR, NLR, and CRP levels had significantly shorter overall survival (OS). Based on univariate analysis, age (≥60 years), gender (men), lower hemoglobin level (<10 g/dl), higher bone marrow blast percentage (>5%), poorer karyotype, and higher Revised International Prognostic Scoring System (IPSS-R) score were significantly associated with shorter OS. Patients with higher CRP levels had shorter leukemia-free survival (LFS, P = 0.041). However, higher PLR and NLR had no significant influence on LFS (P > 0.05). Multivariate Cox proportional hazards regression analysis indicated that high PLR and CRP were also independent adverse prognostic factors for OS in MDS.ConclusionsElevated PLR and CRP predict poor prognosis independent of the IPSS-R and provide a novel evaluation factor for MDS patients.

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Section: Discussionmentioning

confidence: 97%

The Prognostic Value of Pretherapy Peripheral Blood Inflammatory Indices in Myelodysplastic Syndromes

et al. 2022

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“…The World Health Organization prognostic scoring system (WPSS), International Prostate Symptom Score (IPSS-R), and Revised International Prostate Symptom Score (IPSS-R) can be used to evaluate the prognosis of MDS patients by monitoring age, sex, neutrophil count, hemoglobin, platelet count, cytopenia series, bone marrow primitive cell ratio, and karyotype, as well as predict the risk grade of MDS patients and propose related treatment strategies [12][13][14][15]. The percentage of blasts, the number of cytopenic lines, and the cytogenetic indications of bone marrow, are all included in the classification criteria, but immune indicators prognosis are not.…”

Section: Introductionmentioning

confidence: 99%

The value of serum IL-4 to predict the survival of MDS patients

Liu

Liang

et al. 2023

Eur J Med Res

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Background Immune indicators are routinely used for the detection of myelodysplastic syndrome (MDS), but these are not utilized as a reference indicator to assess prognosis in MDS-related prognostic evaluation systems, such as the World Health Organizational prognostic scoring system, the international prostate symptom score, and the revised international prostate symptom score. Methods We examined immune indicators, including cluster of differentiation (CD)3, CD4, CD8, CD56, CD19, interleukin (IL)-2, IL-4, IL-6, IL-10, tumor necrosis factor-a, and interferon-γ in 155 newly diagnosed MDS patients. We also conducted a correlation analysis with clinical indices. Results IL-4 was found to be a predictor of survival in these 155 patients using the receiver operating characteristic curve, with 5.155 as the cut-off point. Patients with serum IL-4 levels ≥ 5.155 had a lower overall survival (OS) than those with IL-45.155 at diagnosis. Furthermore, multivariate analysis revealed that IL-4 levels > 5.155 were an independent predictor of OS (hazard ratio: 0.237; 95% confidence interval, 0.114–0.779; P = 0.013). In addition, serum IL-4 expression in the three different scoring systems showed significant differences in the survival of medium- to high-risk MDS patients (P = 0.014, P < 0.001, P < 0.001). Conclusions According to our study, IL-4 levels at the time of diagnosis can predict MDS prognosis in patients as a simple index reflecting host systemic immunity.

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“… 3 The IPSS-R was found to be the best predicting system for overall survival. 4 The scoring system mainly includes the severity of hemocytopenia (anemia, thrombocytopenia, neutropenia, decreased hemoglobin content), increased bone marrow blasts and cytogenetic factors. However, Della Porta MGet al reported that it is very important to incorporate other factors, such as comorbidities, into the treatment decision.…”

Section: Introductionmentioning

confidence: 99%

Hyperfibrinogenemia as a Poor Prognostic Indicator in Myelodysplastic Syndrome

Shi¹,

Gong²,

Wu³

et al. 2022

CMAR

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Background Myelodysplastic syndrome (MDS) is a group of heterogeneous myeloid clonal diseases originating from hematopoietic stem cells. It has been demonstrated that fibrinogen (FIB) is associated with disease risk in several cancer types. Coagulation and fibrinolysis problems are widespread in MDS patients. Therefore, FIB might be one of these indicators. We thus examined the role of FIB levels in the prognosis of MDS. Methods A cohort of 198 MDS patients were retrospectively analyzed to explore the prognostic value of the plasma FIB levels at diagnosis. Patients were divided into the high FIB group and low FIB group. The prognostic significance of FIB was determined by univariate and multivariate Cox hazard models. Results In our cohort, the FIB levels in 198 MDS patients were higher than those in 100 healthy donors (3.9 g/L vs 2.9 g/L, P < 0.0001). MDS patients with high FIB levels had significantly shorter overall survival (OS; P = 0.001) and decreased leukemia-free survival (LFS; P = 0.036). Multivariate cox proportional hazards regression analysis indicated that, in addition to older age, gender, lower HB, poorer karyotype for OS, lower NE, and higher bone marrow blast percentage for OS and LFS, elevated FIB level was also an independent adverse prognostic factor for OS ( P = 0.045) but not for LFS ( P = 0.188). Conclusion Elevated FIB levels may be associated with mortality risk among MDS patients and could predict disease progress and patient prognosis. Thus, assessment of FIB levels may promote the determination of the prognosis of MDS patients.

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Comparison of Myelodysplastic Syndrome Prognostic Scoring Systems

Cited by 4 publications

References 17 publications

The Prognostic Value of Pretherapy Peripheral Blood Inflammatory Indices in Myelodysplastic Syndromes

The Prognostic Value of Pretherapy Peripheral Blood Inflammatory Indices in Myelodysplastic Syndromes

The value of serum IL-4 to predict the survival of MDS patients

Hyperfibrinogenemia as a Poor Prognostic Indicator in Myelodysplastic Syndrome

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