Comparison of Mycobacterium tuberculosis susceptibility testing performed with BACTEC 460TB (Becton Dickinson) and MB/BacT (Organon Teknika) systems

Tortoli, Enrico; Mattei, Romano; Savarino, Andrea; Bartolini, L.; Beer, J

doi:10.1016/s0732-8893(00)00176-0

Cited by 27 publications

(26 citation statements)

References 9 publications

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“…Our observations are similar to those of Beer et al (1997 a, b), Diaz-Infantes et al (2000), Brunello and Fontana (2000), Tortoli et al (2000), and Yew et al (2001), using the same systems. The results of the tests in the MB/BacT indicate that this system is an accurate method for use in public health laboratories to deal with the workload of susceptibility-testing routines to diagnose multidrugresistant tuberculosis mainly in those states that the prevalence of the disease is high and where the laboratories act as a reference facility to the national network.…”

Section: Discussionsupporting

confidence: 92%

“…In our experiments, all readings of the tests in the MB/BacT were made for a few more days than in BACTEC. This small difference in the final reading test time compared to the BACTEC was also observed by Tortoli et al (2000). The availability of the susceptibility results obtained in our study is within the time limit suggested by Tenover et al (1993) for rapid intervention in the disease transmission chain, acceptable for public health laboratories in this era of TBMDR: no more than 30 days should pass from collection of the clinical material to the time that the results become available.…”

Section: Discussionsupporting

confidence: 82%

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Evaluation of indirect susceptibility testing of Mycobacterium tuberculosis to the first- and second-line, and alternative drugs by the newer MB/BacT system

Barreto

Araújo

Medeiros

et al. 2003

Mem. Inst. Oswaldo Cruz

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 82%

Evaluation of indirect susceptibility testing of Mycobacterium tuberculosis to the first- and second-line, and alternative drugs by the newer MB/BacT system

Barreto

Araújo

Medeiros

et al. 2003

Mem. Inst. Oswaldo Cruz

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“…Two other commercial and automated methods for DST are the MB/BacT system (Organon Technika) and the ESP culture system II (Accumed International, Chicago, IL, USA). Both systems rely on heavy equipment and have also been evaluated in several studies [71,72].…”

Section: Phenotypic Methodsmentioning

confidence: 99%

Nonconventional and new methods in the diagnosis of tuberculosis: feasibility and applicability in the field

Palomino¹

2005

European Respiratory Journal

144

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Tuberculosis (TB) remains one of the major causes of death from a single infectious agent worldwide. Of great concern for TB control is the emergence of drug resistance. Since there is no cure for some multidrug-resistant strains of Mycobacterium tuberculosis, there is concern that they may spread around the world, stressing the need for additional control measures, such as new diagnostics, better drugs for treatment, and a more effective vaccine.Pulmonary TB can be diagnosed by its symptoms, chest radiography, sputum smear microscopy and by cultivation of M. tuberculosis, which is considered as the gold standard. Recent advances in molecular biology and molecular epidemiology, and a better understanding of the molecular basis of drug resistance in TB, have provided new tools for rapid diagnosis; however, the high cost of most of these techniques, and their requirement for sophisticated equipment and skilled personnel have precluded their implementation on a routine basis, especially in low-income countries.Other nonconventional diagnostic approaches proposed include the search for biochemical markers, detection of immunological response and early detection of M. tuberculosis by methods other than colony counting.In the present article, some of these approaches will be reviewed and the feasibility for their implementation in diagnostic laboratories will be discussed.

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“…74,94 The radiometric Bactec 460 and also the automated nonradiometric liquid culture systems also allow susceptibility testing. [95][96][97][98] Reductions in turnaround times from 21 days for LJ-based tests to 6-12 days for automated liquid culture systems for susceptibility testing have been reported. 98,99 The liquid culture methods are expensive, however, and require elaborate technology.…”

Section: Rapid Liquid Culture Systemsmentioning

confidence: 99%

A systematic review of rapid diagnostic tests for the detection of tuberculosis infection

Dinnes¹,

Deeks²,

Kunst³

et al. 2007

Health Technol Assess

530

361

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Comparison of Mycobacterium tuberculosis susceptibility testing performed with BACTEC 460TB (Becton Dickinson) and MB/BacT (Organon Teknika) systems

Cited by 27 publications

References 9 publications

Evaluation of indirect susceptibility testing of Mycobacterium tuberculosis to the first- and second-line, and alternative drugs by the newer MB/BacT system

Evaluation of indirect susceptibility testing of Mycobacterium tuberculosis to the first- and second-line, and alternative drugs by the newer MB/BacT system

Nonconventional and new methods in the diagnosis of tuberculosis: feasibility and applicability in the field

A systematic review of rapid diagnostic tests for the detection of tuberculosis infection

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