Comparison of MRI and Wrist Arthroscopy for Assessment of Wrist                     Cartilage

Mutimer, J; Green, J; Field, J.

doi:10.1177/1753193408090395

Cited by 25 publications

(10 citation statements)

References 4 publications

(6 reference statements)

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“…More than half of the studies assessed joint regions or counted the number of total defects noted rather than numbers of total joints or numbers of patients. 18-20,23,26,28,29,31,33,34 This skewed the weight of each datapoint in the meta-analysis; ideally all of the studies would have one datapoint per subject, or an equal number of surfaces analysed per subject.…”

Section: Discussionmentioning

confidence: 99%

The diagnostic performance of MRI in osteoarthritis: a systematic review and meta-analysis

Menashe

Hirko

Losina

et al. 2012

Osteoarthritis and Cartilage

106

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Objective Osteoarthritis (OA) is currently diagnosed using clinical and radiographic findings. In recent years MRI use in osteoarthritis has increasingly been studied. This study was conducted to determine the diagnostic utility of MRI in OA through a meta-analysis of published studies. Methods A systematic literature search was undertaken to include studies that used MRI to evaluate or detect osteoarthritis. MRI was compared to various reference standards: histology, arthroscopy, radiography, CT, clinical evaluation, and direct visual inspection. Sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and receiver operating characteristic (ROC) area under the curve were calculated. Random effects models were used to pool results. Results Of 20 relevant studies identified from the literature, 16 reported complete data and were included in the meta-analysis, with a total of 1220 patients (1071 with OA and 149 without). Overall sensitivity from pooling data of all the included studies was 61% (95% confidence interval [CI] 53 to 68), specificity was 82% (95% CI 77 to 87), PPV was 85% (95% CI 80 to 88), and NPV was 57% (95% CI 43 to 70). The ROC showed an area under the curve of 0.804. There was significant heterogeneity in the above parameters (I2 >83%). With histology as the reference standard, sensitivity increased to 74% and specificity decreased to 76% compared with all reference standards combined. When arthroscopy was used as the reference standard, sensitivity increased to 69% and specificity to 93% compared with all reference standards combined. Conclusion MRI can detect OA with an overall high specificity and moderate sensitivity when compared with various reference standards, thus lending more utility to ruling out OA than ruling it in. The sensitivity of MRI is below the current clinical diagnostic standards. At this time standard clinical algorithm for OA diagnosis, aided by radiographs appears to be the most effective method for diagnosing OA.

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Section: Discussionmentioning

confidence: 99%

The diagnostic performance of MRI in osteoarthritis: a systematic review and meta-analysis

Menashe

Hirko

Losina

et al. 2012

Osteoarthritis and Cartilage

106

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“…56 However, when it comes to detecting cartilage damage, only a "fair" correlation with a κ of 0.38 was found when using 1.5 T without direct or indirect arthrography. 57 Besides observing cartilage defects, the harmed cartilage is sometimes thickened due to reparative processes or edema (►Fig. 9).…”

Section: Ulnocarpal (Ulnolunate) Impaction (Abutment)mentioning

confidence: 99%

Cartilage Imaging of the Hand and Wrist Using 3-T MRI

Weber

Stillfried

Kloth

et al. 2012

Semin Musculoskelet Radiol

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The prevalence of osteoarthritis of the hand and wrist is high, and a thorough assessment of even subtle cartilage injuries is necessary before surgical interventions. Although magnetic resonance imaging (MRI) has been established as an important diagnostic tool for the evaluation of hand and wrist disorders, the focus has been on the assessment of the triangular fibrocartilage complex, tendons, ligaments, and the detection of avascular necrosis or occult fractures rather than on cartilage imaging. 3-T MR systems have become more and more widely available and yield an improved signal-to-noise ratio and thus a higher spatial resolution than 1.5-T systems. In principle, this should be especially beneficial for depicting the thin cartilage layers of the hand and wrist. This review focuses on cartilage imaging of the hand and wrist with 3-T MRI and addresses these four topics: (1) the advantages of 3-T versus 1.5- and 1-T MRI, (2) dedicated sequence protocols at 3 T including novel three-dimensional sequences, (3) imaging findings in common cases of overuse or sports injury, and (4) functional cartilage imaging techniques of the hand and wrist, for instance, delayed gadolinium-enhanced MRI of the cartilage.

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“…There is controversy in the literature surrounding the diagnostic accuracy of MRI for the assessment of wrist cartilage (5, 59, 63–65). Haime et al (64) reported sensitivities of 18%–41% in the detection of focal cartilage lesions in the proximal carpal row, with specificities of 75%–93%.…”

Section: Cartilage Imagingmentioning

confidence: 99%

Differential regulation of axonal growth and neuromuscular junction assembly by HGF/c‐Met signaling

Madhavan

Peng

2012

Developmental Dynamics

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Background: During vertebrate neuromuscular junction (NMJ) development, contact between motor axons and muscle fibers is followed by pre-and post-synaptic specialization. Using Xenopus nerve-muscle cocultures, we recently showed that spinal neurons initially contacted muscle cells by means of filopodial processes, and that muscle-derived basic fibroblast growth factor induced axonal filopodia and slowed axonal advance to promote nerve-muscle interaction and NMJ establishment. In contrast, neurotrophins enhanced axonal growth but suppressed the extension of axonal filopodia and blocked NMJ formation. Results: Here we report that hepatocyte growth factor (HGF), which also supports motor neuron survival, was expressed by Xenopus muscle cells, and that forced expression of HGF in Xenopus spinal neurons inhibited the extension of axonal filopodia. Overexpression of the HGF-receptor c-Met in neurons also blocked the formation of axonal filopodia and furthermore sped up axonal growth, but a kinase-dead form of c-Met was unable to effect these changes. Importantly, treatment of nerve-muscle cocultures with recombinant HGF or the expression of HGF or active c-Met in neurons, or that of excess HGF in muscle, inhibited nerve-induced AChR clustering in muscle. Conclusions: Our results suggest that HGF/c-Met signaling in neurons promotes axonal growth but suppresses filopodial assembly in neurons and hinders NMJ establishment. Developmental Dynamics 241:1562-1574,

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Comparison of MRI and Wrist Arthroscopy for Assessment of Wrist Cartilage

Cited by 25 publications

References 4 publications

The diagnostic performance of MRI in osteoarthritis: a systematic review and meta-analysis

The diagnostic performance of MRI in osteoarthritis: a systematic review and meta-analysis

Cartilage Imaging of the Hand and Wrist Using 3-T MRI

Differential regulation of axonal growth and neuromuscular junction assembly by HGF/c‐Met signaling

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