Comparison of Morphological and Functional Meibomian Gland Characteristics Between Daily Contact Lens Wearers and Nonwearers

Machalińska, Anna; Zakrzewska, Aleksandra; Adamek, B; Safranow, Krzysztof; Wiszniewska, Barbara; Parafiniuk, Mirosław; Machaliński, Bogusław

doi:10.1097/ico.0000000000000511

Cited by 42 publications

(89 citation statements)

References 19 publications

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“…The examination included several steps as we described previously [10] and was performed sequentially as follows: measurement of the conversational blink rate, slit-lamp examination (including fluorescein staining of the ocular surface), tear film break-up time (TBUT) testing, the Schirmer test, quantification of morphologic lid features, examination of meibum expressibility/quality, and a meibography. TBUT was estimated by placing a single fluorescein strip over the inferior tear meniscus after instilling one drop of saline [11].…”

Section: Methodsmentioning

confidence: 99%

Risk Factors and Symptoms of Meibomian Gland Loss in a Healthy Population

Machalińska

Zakrzewska

Safranow

et al. 2016

Journal of Ophthalmology

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Purpose. The aim of this study was to investigate the relationships between MGL and ocular symptoms, several systemic conditions, and key markers of ocular surface health. Methods. We included into the study 91 healthy volunteers between the ages of 20 and 77 years. We analyzed meibomian gland morphology, function, and lid margin alterations. We correlated our findings with self-reported ocular symptoms, systemic medical history, lifestyle factors, and tear film abnormalities. Results. We observed that a high ocular surface disease index, a history of either chalazion or hordeolum, experience of puffy eyelids upon waking, and foreign body sensation all appeared to be predictors of an abnormal meiboscore after adjusting for age and sex (p = 0.0007; p = 0.001; p = 0.02; p = 0.001, resp.). Multivariate logistic regression model including age and sex showed that there were three independent predictors of abnormal meiboscore: older age (OR = 1.03, 95% CI = 1.01–1.04 per year, p = 0.006), postmenopausal hormone therapy (OR = 4.98, 95% CI = 1.52–16.30, p = 0.007), and the use of antiallergy drugs (OR = 5.85, 95% CI = 2.18–15.72, p = 0.0004). Conclusion. Our findings extend current knowledge on the pathophysiology of MGL.

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Section: Methodsmentioning

confidence: 99%

Risk Factors and Symptoms of Meibomian Gland Loss in a Healthy Population

Machalińska

Zakrzewska

Safranow

et al. 2016

Journal of Ophthalmology

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“…44 Moreover, abnormal meibum quality and lid margin abnormalities are positively correlated with the duration of contact lens wear. 45 While the driving pathophysiology is unknown hypotheses include meibomian gland disruption through mechanical trauma, 46 plugging due to aggregation of desquamated epithelial cells at gland orifices, 47 and/or chronic inflammation. 48 …”

Section: Risk Factors For Mgd and Their Potential Effect On Meibocytesmentioning

confidence: 99%

Meibomian Gland Disease

Chhadva

Goldhardt²,

Galor³

2017

Ophthalmology

240

103

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Meibomian gland dysfunction (MGD) is an umbrella term that encompasses several meibomian gland disorders, ranging from congenital to acquired. Disruption of meibomian gland function negatively impacts both the quality and quantity of meibum secreted, which in turn affects ocular surface health through changes in tear film composition. Increased tear evaporation, hyperosmolarity, inflammation, and ocular surface damage can subsequently occur. This may cause discomfort, visual disruption, and sensation of dry eye. This review article discusses the pathology, causes, and ocular surface impact of MGD, as well as its relationship to dry eye.

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“…Many studies have shown that contact lens wear negatively affects the condition of meibomian glands, [30][31][32][33][34][35][36][37][38] although some have found no relation between lens wear and gland condition. [39][40][41] In wearers of rigid gas-permeable lenses, gland changes were detected at the temporal side in the upper eyelid, whereas wearers of soft contact lenses manifested linear shortening at the distal side in the lower eyelid ( Fig.…”

Section: Contact Lens Wearmentioning

confidence: 99%

Meibography: A Japanese Perspective

Arita

2018

Invest. Ophthalmol. Vis. Sci.

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Meibography allows observation of meibomian glands in an objective and repeatable manner. Original meibography systems were invasive and not readily adopted by ophthalmology clinics. The development of noncontact infrared meibography allowed the rapid and noninvasive observation of meibomian glands, and such systems have now been widely adopted for standard examinations in dry eye clinics. Noncontact meibography has also spurred research into meibomian glands and has been applied to evaluation of their structure and status in various ocular surface diseases. Although the images obtained by meibography are objective and repeatable, the interpretation of these images is subjective, with the relationship between image features and actual gland structure and composition remaining unclear. Additional clinical and basic research with regard to the interpretation of meibography images is thus necessary. Future improvements to meibography will likely provide new insights into the pathophysiology of meibomian gland diseases as well as enhance its contribution to the diagnosis and evaluation of treatments for such diseases.

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Comparison of Morphological and Functional Meibomian Gland Characteristics Between Daily Contact Lens Wearers and Nonwearers

Cited by 42 publications

References 19 publications

Risk Factors and Symptoms of Meibomian Gland Loss in a Healthy Population

Risk Factors and Symptoms of Meibomian Gland Loss in a Healthy Population

Meibomian Gland Disease

Meibography: A Japanese Perspective

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