Comparison of Molecular Mobility in the Glassy State Between Amorphous Indomethacin and Salicin Based on Spin-Lattice Relaxation Times

Masuda, Kasumi; Tabata, Sachio; Sakata, Yoshiharu; Hayase, Tetsuo; Yonemochi, Etsuo; Terada, Katsuhide

doi:10.1007/s11095-005-2597-4

Cited by 40 publications

(37 citation statements)

References 25 publications

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“…[119] Spin-lattice relaxation times recorded via nuclear magnetic resonance (NMR) are also linked to molecular mobility. [120][121][122] However, different techniques might capture different types of mobility. Calorimetric techniques measure viscosity and glass transition related mobility, whereas dielectric spectroscopy, TSDC and NMR are also sensitive for mobility related to localized molecular motions.…”

Section: Alpha and Beta Mobilitymentioning

confidence: 99%

Review: physical chemistry of solid dispersions

2009

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Objectives With poorly soluble drug candidates emerging in the drug discovery pipeline, the importance of the solid dispersion formulation approach is increasing. This strategy includes complete removal of drug crystallinity, and molecular dispersion of the poorly soluble compound in a hydrophilic polymeric carrier. The potential of this technique to increase oral absorption and hence bioavailability is enormous. Nevertheless, some issues have to be considered regarding thermodynamic instability, as well in supersaturated solutions that are formed upon dissolution as in the solid state. Key findings After a brief discussion on the historical background of solid dispersions and their current role in formulation, an overview will be given on the physical chemistry and stability of glass solutions as they form supersaturated solutions, and during their shelf life. Conclusions Thorough understanding of these aspects will elicit conscious evaluation of carrier properties and eventually facilitate rational excipient selection. Thus, full exploitation of the solid dispersion strategy may provide an appropriate answer to drug attrition due to low aqueous solubility in later stages of development.

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Section: Alpha and Beta Mobilitymentioning

confidence: 99%

Review: physical chemistry of solid dispersions

2009

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“…Local mobility (b-relaxation), which may affect the chemical stability of amorphous pharmaceuticals depending on their degradation mechanisms, can be determined by dielectric relaxation 93,94 and NMR relaxation 95,96 measurements. Local mobility, involving motions on a smaller scale than that of global mobility, is thought to be coupled with global mobility, 4,97 although only limited data are available in this regard.…”

Section: Coupling Between Local Mobility and Global Mobilitymentioning

confidence: 99%

Correlations between Molecular Mobility and Chemical Stability During Storage of Amorphous Pharmaceuticals

Yoshioka

Aso

2007

Journal of Pharmaceutical Sciences

204

131

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“…In order to obtain a molecularly resolved picture of the disorder, it is generally necessary to resort to spectroscopic techniques, which provide molecular specificity. The most important practical alternative is nuclear magnetic resonance (NMR) spectroscopy, [11][12][13][14] which can provide information regarding molecular mobility.…”

Section: Introductionmentioning

confidence: 99%