Comparison of midazolam versus clonazepam as premedication scheduled for elective abdominal hysterectomies

Abstract

Background and aim: Anxiety is one of the most common problem which affect the patient during surgical procedures. Thus, anxiolytics have a primary role as premedication preoperatively. With this background, we designed this study to compare anxiolytic effects of oral midazolam and oral clonazepam. Methods: Study was carried out in 80 patients scheduled for elective Abdominal hysterectomy and were divided into group of 40 each. Group M 40 patients were given Tab Midazolam 10 mg, 45 min before surgery. Group C of 40 patients were given Tab Clonazepam 2 mg, 45 min before surgery with a sip of water. All hemodynamic parameters, sedation score, satisfactory score, Hamitlon Anxiety Rating Scale were noted. The patient characteristics were analysed using "Chi-square test" and inter group comparison of the parametric data was done using the "unpaired t-test using software IBM SPSS 17.0. Results: Clonazepam is better anxiolytic than midazolam and has longer duration of anxiolytic effects and with minimal side effects and better hemodynamic stability than midazolam. Conclusion: Tab Clonazepam can be used as premedication to allay anxiety in the patients undergoing elective surgeries.

Comparison Between Clonazepam and Bromazepam as Premedication Drugs to Reduce Anxiety in Patients Undergoing Elective Surgery Under General Anaesthesia

“…But clonazepam found to be better anxiolytic than midazolam. 12 Kumar et al found that buccal clonazepam demonstrated equivalence to I/V midazolam in controlling acute breakthrough seizure. When extrapolated to domiciliary setting it is likely to be safe option with capability of decreasing status episodes, hospitalization and thus reducing economic burden and psychological stress to the family.…”