Abstract:Two-dimensional (2D) cell culture systems are important tools for basic in vitro research. However, they form a thin monolayer structure and poorly mimic the complex in vivo conditions in terms of biochemical signals, cell-cell and cell-extracellular matrix (ECM) interactions. In this study, we performed a comparative study on SH-SY5Y and SK-N-AS neuroblastoma cell lines in terms of their microtissue forming capacity. Both cell lines are commonly used to model neurodegenerative diseases in vitro. Cells were cu… Show more
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