Comparison of microsuture, interpositional nerve graft, and laser solder weld repair of the rat inferior alveolar nerve

Curtis, Nigel J.

doi:10.1016/j.ijom.2011.07.052

Cited by 2 publications

(3 citation statements)

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“…In a comparative study of primary repair, delayed repair, and nerve graft, good to excellent results were achieved in 78% of the primary repair group but only 33.3% of the nerve graft group [22]. Similarly, in another study comparing microsuture, interpositional nerve graft, and laser solder weld repair of the rat inferior alveolar nerve, interpositional nerve graft was the least effective [23]. If direct nerve repair is impossible or excessive tension is applied to the repaired nerve such that nerve regeneration is interrupted, a nerve graft should be performed, while taking into account the likelihood of a much poorer outcome than is the case in nerve repair.…”

Section: Discussionmentioning

confidence: 98%

Nerve Repair and Orthodromic and Antidromic Nerve Grafts: An Experimental Comparative Study in Rabbit

Kim

Choi

Kim

et al. 2020

BioMed Research International

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Purpose. Although many surgeons have anecdotally described reversing the polarity of the autograft with the intent of improving regeneration, the optimal orientation of the autogenous nerve graft remains controversial. The aim of this study was to compare (1) the outcomes of orthodromic and antidromic nerve grafts to clarify the effect of nerve graft polarity and (2) the outcome of either form of nerve grafts with that of nerve repair. Methods. In 14 of the 26 rabbits used in this study, a 1 cm defect was made in the tibial nerve. An orthodromic nerve graft on one side and an antidromic nerve graft on the other were performed using a 1.2 cm long segment of the peroneal nerve. In the remaining 12 rabbits, the tibial nerve was transected completely and then repaired microscopically on one side but left untreated on the other. Electrophysiologic studies were performed in all animals at 8 weeks after surgery, and the sciatic nerves were harvested. Results. Compound motor action potential was visible in all rabbits treated by nerve repair but in only half of the rabbits treated by nerve graft. There was no significant difference in the compound motor action potential, nerve conduction velocity, or total number of axons between the orthodromic and antidromic nerve graft groups. However, in both groups, the outcome was significantly poorer than that of the nerve repair group. Conclusion. There was no significant difference by electromyographic or histologic evaluation between orthodromic and antidromic nerve grafts. Direct nerve repair with moderate tension may be a more effective treatment than nerve grafting.

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Section: Discussionmentioning

confidence: 98%

Nerve Repair and Orthodromic and Antidromic Nerve Grafts: An Experimental Comparative Study in Rabbit

Kim

Choi

Kim

et al. 2020

BioMed Research International

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“…Since it was impossible to determine whether the nerve tissue was functionally restored based on the histologic shape alone, electrostimulation tests were conducted from the neurophysiologic viewpoint. As an experiment on the functional recovery of nerve after injury, perception tests may be performed; note, however, that erroneous results such as the reflex reactions of animals may appear 10) . In the case of ordinary electrostimulation tests, the degree of nerve recovery was indirectly checked by verifying whether the depolarization of nerve was delivered through electromyography (EMG).…”

Section: Discussionmentioning

confidence: 99%

“…Nonetheless, there are practically no research studies on the same animal experimental models that can be applied to repeated tests. Furthermore, even the animal experimental models announced to date are limited to histologic research 10) . Therefore, this study attempted to develop animal models capable of conducting electrophysiologic tests that can verify IAN damage and recovery of functions using the NGF and polymeric membrane.…”

Section: Introductionmentioning

confidence: 99%

Animal Model for the Evaluation of Repair of Injured Inferior Alveolar Nerve with Nerve Growth Factor

Lee¹,

Park²,

Heo³

et al. 2013

Journal of Korean Dental Science

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The inferior alveolar nerve (IAN) can be damaged as a result of minor oral surgical procedure such as third molar extraction or implant placement. Repair of the injured IAN involves difficulty of access, and research studies are limited to elucidating the process of regeneration by surgical methods. This study sought to establish the rabbit animal model to apply polymeric membrane functionalized with nerve growth factor after a crush lesion for the evaluation of nerve regeneration using the electrophysiologic method. Materials and Methods: The IAN of 2 adult male New Zealand white rabbits (4 nerves) were exposed bilaterally, and crush injury rendered by jeweler's forceps was applied. Nerve conduction velocity was examined electrophysiologically using electromyography before, after, and 4 weeks after the crush injury. To evaluate the regeneration, the pattern of action potential of IAN was recorded, and the characteristics of neurons were histologically observed. Result: After the crush injury, afferent activity decreased in the injured group. Electromyography could not be recorded after four weeks because tissues surrounding the injured nerve collapsed. Decrease in the mean number of axons was observed in the injured part with membrane. Conclusion: Despite the limited result, the present animal model study may provide a possible way to research on the methods of enhancing the recovery of nerve injuries in clinical situations. For clinically widespread acceptance, however, it should gain more consecutive and scientific evidences.

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Comparison of microsuture, interpositional nerve graft, and laser solder weld repair of the rat inferior alveolar nerve

Cited by 2 publications

References 0 publications

Nerve Repair and Orthodromic and Antidromic Nerve Grafts: An Experimental Comparative Study in Rabbit

Nerve Repair and Orthodromic and Antidromic Nerve Grafts: An Experimental Comparative Study in Rabbit

Animal Model for the Evaluation of Repair of Injured Inferior Alveolar Nerve with Nerve Growth Factor

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