Comparison of microstructures of microemulsion and swollen micelle in electrokinetic chromatography

Cao, Yuhua; Ni, Xiaomin; Sheng, Jianwei

doi:10.1016/j.chroma.2011.02.015

Cited by 18 publications

(15 citation statements)

References 34 publications

(34 reference statements)

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“…The ensuing method was successfully validated and used for amino acid profiling in medicinal preparations for parenteral nutrition. In the other contribution, the modifier effect of 1‐butanol on SDS (swollen micelle) in MEKC separations was studied in depth and compared with that of the corresponding typical microemulsion containing n ‐octane . For this purpose, three types of corticosteroids were separated by using both methodologies to assess their separation performance.…”

Section: Approaches To Improving Resolutionmentioning

confidence: 99%

Micellar electrokinetic chromatography: A review of methodological and instrumental innovations focusing on practical aspects

Silva

2012

Electrophoresis

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This review article addresses recent methodological and instrumental innovations in MEKC with emphasis on practical aspects. Like its predecessors, this review is intended to provide an updated overview covering work on the most salient methodological contributions to enhancing sensitivity and resolution in MEKC-based determinations published over the past two years. The most widespread approaches to enhancing sensitivity, which include improving "classical" online sample concentration techniques, combinations of on- and off-line sample concentration protocols and recent developments are discussed, and so are modifications of existing MEKC systems with various micellar phases, the use of BGE additives (organic modifiers, chiral selectors, gold nanoparticles) and coated capillaries, and the implementation of 2D separations and chemometric methods to enhance resolution. Instrumental approaches such as MS and LIF are also discussed, and proposals for overcoming the problems typically encountered in directly coupling MEKC with MS, and the recent inception of quantum dots with a great potential for LIF detection in MEKC, are also dealt with. Finally, foreseeable developments on potential future directions are also expressed.

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Section: Approaches To Improving Resolutionmentioning

confidence: 99%

Micellar electrokinetic chromatography: A review of methodological and instrumental innovations focusing on practical aspects

Silva

2012

Electrophoresis

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“…Based on the literature, the inherent advantages/disadvantages of either modality appears to be analyte dependent. Recent work by Cao et al compared an MEEKC and 1‐butanol‐modified MEKC system in terms of microdroplet structure and the corresponding separation of three corticosteroids. It was seen that both systems possessed similar physicochemical properties and performed equally well in terms of separation performance.…”

Section: Comparison Of Meekc and Mekcmentioning

confidence: 99%

“…In MEEKC, an increase in the co‐surfactant concentration, such as n‐butanol, can result in an increased droplet size . This plays an important role in both the analytes ability to partition with the PSP and also the charge density associated with the droplet.…”

Section: Operating Parameters In Meekcmentioning

confidence: 99%

“…While the ME composition lends itself to a large number of method development options, it can be time consuming to determine the optimum concentration of each component. However, recent advances in characterizing the ME structure , structure–activity relationships , partitioning mechanisms , and chemometric/experimental design may result in an improved understanding and choice of ME components.…”

Section: Prediction Of Solute Characteristics and Partitioning Mechanmentioning

confidence: 99%

“…Cao et al recently characterized an ME (3.3% SDS, 6.6% 1‐butanol, and 0.8% n ‐octane in a 20 mM borax buffer) and 1‐butanol‐modified MEKC (composition as ME system without presence of n‐octane) buffer system in terms of hydrodynamic radius, electrokinetic potential ζ at the hydrodynamic shear surface and microenvironment polarity in the interior of the droplet. The authors also correlated the measured parameters with the separation of three corticosteroids (prednisone, prednisolone, and hydrocortisone).…”

Section: Prediction Of Solute Characteristics and Partitioning Mechanmentioning

confidence: 99%

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A review of developments in the methodology and application of microemulsion electrokinetic chromatography

Ryan

Altria

McEvoy³

et al. 2012

Electrophoresis

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MEEKC is a mode of CE, which utilizes microemulsion (ME) as the BGE to achieve separation of a diverse range of analytes. MEs are composed of nanometer-sized oil droplets suspended in aqueous buffer which are stabilized by the presence of a surfactant and co-surfactant. These MEs are commonly referred to as oil-in-water MEs and their application in MEEKC has been extensively examined. This review details advances in the theory, methodology, and application of MEEKC during the period 2010-2012. Areas covered include online sample concentration, advances in chiral separations, use of coated capillaries, chemometric approaches, and the use of novel additives to the ME system. This review also provides the reader with an introduction to MEEKC and a presentation of recent applications.

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Evolution of aqueous micellar solutions in the injection fluids of alkaline–surfactant–polymer and alkaline–surfactant floodings from injection to production

Zhao

Wang

et al. 2017

Asia-Pacific J Chem Eng

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In an effort to determine the sources of the nanomicron and submicron oil droplets in the produced water of an industrial ASP flooding project conducted at Daqing fields, evolution of the lower aqueous phases in artificial ASP and AS flooding injection fluids during aging in contact with crude oil and after dilution by reservoir brine was investigated by means of dynamic light scattering and oil content determination. Nanosize swollen micelles were identified in the lower aqueous phases of the artificial ASP and AS flooding injection fluids during aging in contact with crude oil. Slow solubilization of crude oil components by micelles in the lower aqueous phase was observed. Nanomicron and submicron oil droplets were detected in the artificially produced water, which were prepared by diluting the lower aqueous phases of aged artificial AS and ASP flooding injection fluids with reservoir brine to surfactant contents below critical micelle concentration. The nanomicron and submicron oil droplets identified in the blended produced water entering water treatment facilities of the ASP flooding project were determined to have evolved mainly from the swollen micelles in the injection fluid, which broke up when the surfactant content fell to bellow critical micelle concentration.

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Comparison of microstructures of microemulsion and swollen micelle in electrokinetic chromatography

Cited by 18 publications

References 34 publications

Micellar electrokinetic chromatography: A review of methodological and instrumental innovations focusing on practical aspects

Micellar electrokinetic chromatography: A review of methodological and instrumental innovations focusing on practical aspects

A review of developments in the methodology and application of microemulsion electrokinetic chromatography

Evolution of aqueous micellar solutions in the injection fluids of alkaline–surfactant–polymer and alkaline–surfactant floodings from injection to production

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