Comparison of microbial profiles and viral status along the vagina-cervix-endometrium continuum of infertile patients

Jain, Mark; Mladova, Elena; Dobychina, Anna; Kirillova, K.; Shichanina, Anna; Anokhin, D. M.; Scherbakova, Liya; Samokhodskaya, L М; Панина, О.Б.

doi:10.1080/19396368.2023.2195040

Cited by 4 publications

(2 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A total of 75 citations were excluded based on title and abstract. Hence, a total of 16 citations [15,16 ▪▪ ,19–21,29,30–39] were assessed for eligibility by examination of the full text. Seven studies were removed due to study design [29,33–36,38,39] and four were removed as it was not possible to extract pregnancy outcome data for the meta-analysis [30–32,37].…”

Section: Resultsmentioning

confidence: 99%

“…Hence, a total of 16 citations [15,16 ▪▪ ,19–21,29,30–39] were assessed for eligibility by examination of the full text. Seven studies were removed due to study design [29,33–36,38,39] and four were removed as it was not possible to extract pregnancy outcome data for the meta-analysis [30–32,37]. Further searches in additional databases yielded five relevant papers [23 ▪ ,40–43], however, only the study by Väinämö et al [23 ▪ ] met the eligibility criteria and was included.…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Vaginal dysbiosis – the association with reproductive outcomes in IVF patients: a systematic review and meta-analysis

Maksimovic Celicanin,

Haahr,

Humaidan

et al. 2024

Current Opinion in Obstetrics &Amp; Gynecology

View full text Add to dashboard Cite

Purpose of review To examine impact of vaginal dysbiosis (VD), including bacterial vaginosis (BV) and aerobic vaginitis (AV) on reproductive outcomes of in vitro fertilization (IVF) patients. Recent findings BV-bacteria (e.g. Gardnerella) and AV-bacteria (e.g. Streptococci and Enterococci) have been identified in the endometrium. However, there is inconclusive evidence whether IVF patients with VD have lower success rates. Summary The present systematic review and meta-analysis of PubMed/Medline, until December 2023 included 25 studies, involving 6835 IVF patients. Overall VD was defined as an approximation of community state type IV, including BV and AV-type dysbiosis based on either molecular or microscopy methods. Outcomes were live birth rate (LBR), early pregnancy loss (EPL), clinical pregnancy rate (CPR), and biochemical pregnancy rate (BPR). Vaginal dysbiosis prevalence was 19% [1271/6835, 95% confidence interval (CI) 18–20%]. Six studies examined AV-type dysbiosis with a prevalence of 4% (26/628, 95% CI 3–6%). Vaginal dysbiosis correlates with a higher EPL [relative risk (RR) = 1.49, 95% CI 1.15–1.94] and lower CPR (RR = 0.82, 95% CI 0.70–0.95). No statistically significant impact of VD, BV, or AV was found on LBR and BPR. Thus, the association between VD and reproductive outcome remains puzzling as it is difficult to explain how VD impacts CPR and EPL but not LBR and BPR.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Vaginal dysbiosis – the association with reproductive outcomes in IVF patients: a systematic review and meta-analysis

Maksimovic Celicanin,

Haahr,

Humaidan

et al. 2024

Current Opinion in Obstetrics &Amp; Gynecology

View full text Add to dashboard Cite

show abstract

Prevalence of human papilloma virus and Chlamydia trachomatis in endometrial and cervical carcinoma: a comparative study in North Indian women

Gautam,

Mehta,

Nayar

et al. 2023

Systems Biology in Reproductive Medicine

View full text Add to dashboard Cite

Endometrial Microbiome and Its Correlation to Female Infertility: A Systematic Review and Meta-Analysis

Foteinidou,

Exindari,

Chatzidimitriou

et al. 2024

Acta Microbiologica Hellenica

View full text Add to dashboard Cite

The endometrial cavity was considered sterile until the second half of the 20th century. Through modern technological advances and the sequencing of the bacterial 16S rRNA gene, it was proven that the area possesses its own unique microbiome, which can be categorised into two types, Lactobacillus-dominant (LD, with a Lactobacillus spp. abundance percentage greater than 90%) and non-Lactobacillus-dominant (non-LD, with a Lactobacillus spp. abundance percentage smaller than 90%), with other species like Bifidobacterium, Gardnerella, Prevotella, and Streptococcus also being prominent. The aim of this study was to investigate the possible correlation of the endometrial microbiome to female infertility, through the identification and appraisal of studies published in the databases PubMed, Web of Science, and Scopus. Moreover, 12 studies met the research criteria, including the analysis of endometrial fluid or tissue samples from infertile women through PCR, culturomics-based, or NGS methods. According to most of these studies, a eubiotic LD-type microbiome seems to be best for maximising endometrial receptivity and pregnancy chances, whereas a dysbiotic non-LD-type microbiome, with increased α-diversity and a higher number of pathogens, has a harmful effect. There were few studies that presented contradictory results without, however, a satisfactory explanation. Thus, more time and a greater number of studies are required to clarify contradictions and achieve more certain results.

show abstract

Comparison of microbial profiles and viral status along the vagina-cervix-endometrium continuum of infertile patients

Cited by 4 publications

References 36 publications

Vaginal dysbiosis – the association with reproductive outcomes in IVF patients: a systematic review and meta-analysis

Vaginal dysbiosis – the association with reproductive outcomes in IVF patients: a systematic review and meta-analysis

Prevalence of human papilloma virus and Chlamydia trachomatis in endometrial and cervical carcinoma: a comparative study in North Indian women

Endometrial Microbiome and Its Correlation to Female Infertility: A Systematic Review and Meta-Analysis

Contact Info

Product

Resources

About