Comparison of Methylguanidine Production from Creatinine and Creatol in vivo

Yokozawa, Takako; Fujitsuka, Naoki; Oura, Hikokíchi; Ienaga, Kazuharu; Nakamura, Ko

doi:10.1159/000186398

Cited by 22 publications

(14 citation statements)

References 7 publications

(8 reference statements)

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“…48 ) In addition, we have previously reported that both a tannin mixture and (-)-epigallocatechin 3-0-gallate caused a significant decrease in the urinary excretion ofmethylguanidine from rats with renal failure. 49 ) Considering this together with the finding that active oxygen was involved in the mechanism for methylguanidine production, on the basis of our in vivo 50 ) and in vitro experiments, 51) we conclude that tannin has a radical-scavenging action. The results of the present study show that tannin also has a blood pressure-lowering action in renal hypertension, indicating the broad spectrum of action of green tea tannin.…”

Section: Discussionmentioning

confidence: 75%

Depressor Effect of Tannin in Green Tea on Rats with Renal Hypertension

Yokozawa

Oura

Sakanaka

et al. 1994

Bioscience, Biotechnology, and Biochemistry

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Section: Discussionmentioning

confidence: 75%

Depressor Effect of Tannin in Green Tea on Rats with Renal Hypertension

Yokozawa

Oura

Sakanaka

et al. 1994

Bioscience, Biotechnology, and Biochemistry

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“…[8] Approximately 0.2% of Cr is oxidized by hydroxyl radicals in healthy subjects. [7,10] Because oxidized metabolites are excreted into the urine, the concentrations of CTL and MG in the urine can be determined. Serum levels of MG have been investigated since Giovanetti's group reported that MG accumulates in the serum of uremic patients as a uremic toxin.…”

Section: Discussionmentioning

confidence: 99%

“…[9][10][11] Serum and urine Cr, CTL, and MG levels were determined by means of high-performance liquid chromatography with 9, 10-phenanthrenequinone used as a fluorogenic reagent. [9][10][11] Intra-and inter-assay coefficients of variation (CVs) for the determination of CTL were 1.05% and 1.84%, respectively. CVs for peak area and retention time were 1.05% and 0.39%, respectively.…”

Section: Methodsmentioning

confidence: 99%

“…[9,10] CTL and MG are detectable in the urine but not the serum of healthy individuals. Serum MG is undetectable in patients with early stage renal failure; it is detected only in patients with end-stage renal failure.…”

Section: Introductionmentioning

confidence: 93%

“…Thus, the serum CTL level and the CTL/Cr molar ratio are also reported to be good biomarkers of hydroxyl radicals. [10][11][12][13] Theoretically, the molar sum, CTL+MG, and its ratio to Cr, (CTL+MG)/Cr, may be the best indices for the precise hydroxyl radical level in vivo.…”

Section: Introductionmentioning

confidence: 99%

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Urinary Excretion of Creatol, an In Vivo Biomarker of Hydroxyl Radical, in Patients with Chronic Renal Failure

et al. 2007

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Creatol (CTL) is a hydroxyl radical adduct of creatinine (Cr). The serum methylguanidine (MG) level and the MG/Cr molar ratio are reported to be biomarkers for oxidative stress. The aim of this study was to examine whether urinary excretion of CTL, another oxidative stress-related marker, is increased in patients with chronic renal failure (CRF). One hundred twentyfour non-dialyzed patients with chronic renal failure (serum Cr level, 1.3-10.0 mg/dL) were recruited from our hospitals. Urine and serum levels of CTL and MG were determined by high-performance liquid chromatography with the use of 9, 10-phenanthrenequinone as a fluorogenic reagent. The CTL/Cr and (CTL+MG)/Cr molar ratios in spot urine samples were also compared with those in 24-h urine samples. The urinary CTL/Cr and (CTL+MG)/Cr molar ratios increased with decreases in Cr clearance in patients with CRF. Correlations between serum and spot urine (CTL+MG)/Cr and between serum and spot urine CTL/Cr were quite similar to those in 24-h urine samples. CTL/Cr and (CTL+MG)/Cr molar ratios in both 24-h urine and spot urine samples appear to be useful indices of the severity of CRF.

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Effects of Dan Shen preparations on blood and urine components in rats with renal failure

Yokozawa

Oura

Nonaka

et al. 1993

Phytotherapy Research

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Two Dan Shen preparations commercially available in China were given intraperitoneally to rats with renal failure in order to investigate their effects on blood and urine components. In rats given an injection of compound Dan Shen composed of Dan Shen and Jiang Xiang, effects similar to those found after administration of magnesium lithospermate B (the active constituent of Dan Shen) alone were observed. In contrast, in rats given noncompound Dan Shen containing almost no magnesium lithospermate B as revealed by high-performance liquid chromatographic analysis, there was a significant decrease only in the blood levels of urea nitrogen and inorganic phosphorus.

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Comparison of Methylguanidine Production from Creatinine and Creatol in vivo

Cited by 22 publications

References 7 publications

Depressor Effect of Tannin in Green Tea on Rats with Renal Hypertension

Depressor Effect of Tannin in Green Tea on Rats with Renal Hypertension

Urinary Excretion of Creatol, an In Vivo Biomarker of Hydroxyl Radical, in Patients with Chronic Renal Failure

Effects of Dan Shen preparations on blood and urine components in rats with renal failure

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