Comparison of methods for the measurement of radiation dose distributions in high dose rate (HDR) brachytherapy: Ge‐doped optical fiber, EBT3 Gafchromic film, and PRESAGE<sup>®</sup> radiochromic plastic

Palmer, A.L.; Pietro, P. Di; Alobaidli, Sheaka; Issa, Fatma; Doran, Simon J.; Bradley, D.A.; Nisbet, Andrew

doi:10.1118/1.4805100

Cited by 29 publications

(27 citation statements)

References 65 publications

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“…Branchytherapy has the advantage of focusing the radiation dose within a 1 cm diameter treatment volume and quickly disappearing thereafter [18]. For NPC, this feature maximizes the radiation dose delivered to the residual lesions, and minimizes the exposure of normal adjacent organs to irradiation [9].…”

Section: Discussionmentioning

confidence: 99%

Endoscope-Guided Interstitial Intensity-Modulated Brachytherapy and Intracavitary Brachytherapy as Boost Radiation for Primary Early T Stage Nasopharyngeal Carcinoma

et al. 2014

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BackgroundIntracavitary brachytherapy (ICBT) is usually applied as boost radiotherapy for superficial residual of nasopharyngeal carcinoma (NPC) after primary extern-beam radiptherapy (ERT). Here, we evaluated the outcome of endoscope-guided interstitial intensity-modulated brachytherapy (IMBT) boost radiation for deep-seated residual NPC.Methodology/Principal FindingsTwo hundred and thirteen patients with residual NPC who were salvaged with brachytherapy boost radiation during 2005–2009 were analyzed retrospectively. Among these patients, 171 patients had superficial residual NPC (≤1 cm below the nasopharyngeal epithelium) were treated with ICBT boost radiation, and interstitial IMBT boost radiation was delivered to 42 patients with deep-seated residual NPC (>1 cm below the nasopharyngeal epithelium). We found that IMBT boost subgroup had a higher ratio of T2b (81.0% VS 34.5%, P<0.001) and stage II (90.5% VS 61.4%, P = 0.001) than that of ICBT boost subgroup. The dosage of external-beam radiotherapy in the nasopharyngeal (63.0±3.8 VS 62.6±4.3 Gray (Gy), P = 0.67) and regional lymph nodes (55.8±5.0 VS 57.5±5.7 Gy, P = 0.11) was comparable in both groups. For brachytherapy, IMBT subgroup had a lower boost radiation dosage than ICBT subgroup (11.0±2.9 VS 14.8±3.2 Gy, P<0.01). Though the IMBT group had deeper residual tumors and received lower boost radiation dosages, both subgroups had the similar 5-year actuarial overall survival rate (IMBT VS ICBT group: 96.8% VS 93.6%, P = 0.87), progression-free survival rate (92.4% VS 86.5%, P = 0.41) and distant metastasis-free survival rate (94.9% VS 92.7%, P = 0.64). Moreover, IMBT boost radiation subgroup had a similar local (97.4% VS 94.4%, P = 0.57) and regional (95.0% VS 97.2%, P = 0.34) control to ICBT subgroup. The acute and late toxicities rates were comparable between the both subgroups.Conclusions/SignificanceIMBT boost radiation may be a promising therapeutic selection for deep-seated residual NPC.

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Section: Discussionmentioning

confidence: 99%

Endoscope-Guided Interstitial Intensity-Modulated Brachytherapy and Intracavitary Brachytherapy as Boost Radiation for Primary Early T Stage Nasopharyngeal Carcinoma

et al. 2014

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“…Radiochromic film dosimeters are frequently used for measurements of planar dose distributions, because they have advantageous properties compared to other two-dimensional detectors, such as diodes, ionization chamber arrays, optical fibers and gel dosimeters (Palmer et al, 2013). Radiochromic films show great potentiality in particular in applications where there is a very high dose gradient and relatively high absorbed dose rates (Soares, 2007).…”

Section: Introductionmentioning

confidence: 99%

Measurements of 2D distributions of absorbed dose in protontherapy with Gafchromic EBT3 films

Gambarini

Regazzoni

Artuso

et al. 2015

Applied Radiation and Isotopes

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“…Films were scanned in red-green-blue (RGB) format using a 48-bit scanner (Epson Expression 10000 XL) at 72 dpi, in transmission mode, and with no color or sharpness corrections. EBT3 film is energy independent down to energies as low as 50 keV (Massillon-Jl 2012) and use in 192 Ir brachytherapy applications has been previously validated (Palmer et al 2013). All film measurements were made at the surface as well as depths of 2 mm and 6 mm in a stack of RMI 457 solid water of 8 mm total thickness.…”

Section: Methodsmentioning

confidence: 99%

Design and characterization of an economical¹⁹²Ir hemi-brain small animal irradiator

Grams

Wilson

Sio

et al. 2014

International Journal of Radiation Biology

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Purpose To describe the design and dosimetric characterization of a simple and economical small animal irradiator. Materials and methods A high dose rate (HDR) 192Ir brachytherapy source from a commercially available afterloader was used with a 1.3 cm thick tungsten collimator to provide sharp beam penumbra suitable for hemi-brain irradiation of mice. The unit was equipped with continuous gas anesthesia to allow robust animal immobilization. Dosimetric characterization of the device was performed with Gafchromic film measurements. Results The tungsten collimator provided a sharp penumbra suitable for hemi-brain irradiation, and dose rates on the order of 200 cGy/minute were achieved. The sharpness of the penumbra attainable with this device compares favorably to those measured experimentally for 6 MV photons, and 6 and 20 MeV electron beams from a linear accelerator, and was comparable to those measured for a 300 kVp orthovoltage beam and a Monte Carlo simulated 90 MeV proton beam. Conclusions Due to its simplicity and low cost, the apparatus described is an attractive alternative for small animal irradiation experiments requiring steep dose gradients.

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Comparison of methods for the measurement of radiation dose distributions in high dose rate (HDR) brachytherapy: Ge‐doped optical fiber, EBT3 Gafchromic film, and PRESAGE^® radiochromic plastic

Cited by 29 publications

References 65 publications

Endoscope-Guided Interstitial Intensity-Modulated Brachytherapy and Intracavitary Brachytherapy as Boost Radiation for Primary Early T Stage Nasopharyngeal Carcinoma

Endoscope-Guided Interstitial Intensity-Modulated Brachytherapy and Intracavitary Brachytherapy as Boost Radiation for Primary Early T Stage Nasopharyngeal Carcinoma

Measurements of 2D distributions of absorbed dose in protontherapy with Gafchromic EBT3 films

Design and characterization of an economical¹⁹²Ir hemi-brain small animal irradiator

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Comparison of methods for the measurement of radiation dose distributions in high dose rate (HDR) brachytherapy: Ge‐doped optical fiber, EBT3 Gafchromic film, and PRESAGE® radiochromic plastic

Cited by 29 publications

References 65 publications

Endoscope-Guided Interstitial Intensity-Modulated Brachytherapy and Intracavitary Brachytherapy as Boost Radiation for Primary Early T Stage Nasopharyngeal Carcinoma

Endoscope-Guided Interstitial Intensity-Modulated Brachytherapy and Intracavitary Brachytherapy as Boost Radiation for Primary Early T Stage Nasopharyngeal Carcinoma

Measurements of 2D distributions of absorbed dose in protontherapy with Gafchromic EBT3 films

Design and characterization of an economical192Ir hemi-brain small animal irradiator

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Product

Resources

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Comparison of methods for the measurement of radiation dose distributions in high dose rate (HDR) brachytherapy: Ge‐doped optical fiber, EBT3 Gafchromic film, and PRESAGE^® radiochromic plastic

Design and characterization of an economical¹⁹²Ir hemi-brain small animal irradiator