Comparison of methods for quantitative analysis of ranibizumab and bevacizumab in human plasma using various bioanalytical techniques, including microfluidic immunoassay, triple quadrupole, and high-resolution liquid chromatography-tandem mass spectrometry approaches

DelGuidice, Catherine E; Ismaiel, Omnia A.; Mylott, William; Halquist, Matthew S.

doi:10.1016/j.jpba.2022.114823

Cited by 5 publications

(3 citation statements)

References 22 publications

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“…Additionally, they require personnel (although, the "new" MALDI-ToF does not) with specialized training, and, due to batch processing, tend to have longer turnaround times (which has been successfully reduced). In contrast, immunoassays tend to be more easily automated and require less training but are more susceptible to interference and can require higher-priced reagents, hence costing more to run [36,69,74,75]. On the other hand, the cost of running LC-MS practically does not exist, however financial considerations for purchasing an MS are substantial.…”

Section: Feasibilitymentioning

confidence: 99%

Mass Spectrometry-Based Techniques Towards OMICS 2.0

Šoša¹

2023

Preprint

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The literature was scoped to help place mass spectrometric (MS) platforms in the spotlight of the life sciences, as a tool of OMICS and OMICS 2.0 technologies. Moreover, today’s appliances are so handy, that they literally place a whole lab on a single chip. Methods of OMICS (and the most recently developed term OMICS 2.0) are tackled, having in mind their aptness for educational purposes, as well as their feasibility. This same topic was highlighted in many reviews that have been periodically published. The author’s initial interest was the forensic application of MS, but since these interests changed, terms such as “biosensors” were also examined, so the review included means of discovery of efficient biomarkers and clinical therapeutic targets. Aside from simply reviewing the research status and the future perspectives, this article tackles terms such as Society 5.0 and OMICS 2.0. However, within the framework of this review, physical chemistry, bioinformatics, or specific software solutions were not specifically studied. Since the topic of generating permanent collections of digital content for retrospective analysis was also reviewed, the need for loads of data – cloud storage was discussed in the context of MS. These large quantities of data are easier to operate with if generated by MS, rather than by any other commercially available assay. In this manner, the review has strengthened an in-depth understanding of the applications of MS.

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Section: Feasibilitymentioning

confidence: 99%

Mass Spectrometry-Based Techniques Towards OMICS 2.0

Šoša¹

2023

Preprint

View full text Add to dashboard Cite

show abstract

Section: Feasibilitymentioning

confidence: 99%

Mass Spectrometry-Based Techniques Towards OMICS 2.0

Šoša¹

2022

Preprint

View full text Add to dashboard Cite

The literature was scoped to help place mass spectrometric (MS) platforms in the spotlight of the life sciences, as a tool of OMICS and OMICS 2.0 technologies. These methods were discussed, and their feasibility was highlighted in many reviews that have been periodically published, in addition to the most recently developed term OMICS 2.0. This author’s primary interest was the forensic application of MS, but since these interests got broadened, terms such as “biosensors” were also included. So, means of discovery of efficient biomarkers and clinical therapeutic targets were also reviewed. However, within the framework of this review, physical chemistry, bioinformatics, or specific software solutions were not specifically scoped. Aside from simply reviewing the research status and the future perspectives, this article tackles terms such as Society 5.0 and OMICS 2.0. Since the topic of generating permanent collections of digital content for retrospective analysis was reviewed, what requires loads of data – cloud storage is discussed in the context of MS. In this manner, the review has strengthened an in-depth understanding of the applications of MS. These large quantities of data are easier to operate with if generated by MS, rather than by any other commercially available assay.

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“…In the last two decades, protein Aor G-coated magnetic beads have become commercially available and have been widely used as a purication method in the quantication of mAbs by LC-MS/MS. 17,25,29,37,38 They interact with the Fc region (CH 2 -CH 3 interface) and Fab region (VH domain for protein A and CH 1 for protein G). However, peptostreptococcal protein L, a surface Ig-binding protein from Peptostreptococcus magnus, does not interfere with the Fc region.…”

Section: Introductionmentioning

confidence: 99%