Comparison of Metals and Tetracycline as Selective Agents for Development of Tetracycline Resistant Bacterial Communities in Agricultural Soil

Song, Jianxiao; Rensing, Christopher; Holm, Peter E.; Virta, Marko; Brandt, Kristian K.

doi:10.1021/acs.est.6b05342

Cited by 160 publications

(89 citation statements)

References 50 publications

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“…Pollution with metals is especially problematic as metals are highly 65 persistent and toxic even at low concentrations (Gadd and Griffiths 1977). In certain 66 environmental settings, heavy metals such as Cu and Zn may even constitute stronger 67 selective agents for antibiotic resistance than the antibiotic itself (Song et al 2017). 68…”

Section: Introduction 46mentioning

confidence: 99%

Zinc can counteract selection for ciprofloxacin resistance

Vos

Sibleyras

et al. 2019

Preprint

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Phone: (+44)7497497338 21 ORCID: 0000-0002-4169-6548 22 Graphical abstract 23 24One sentence summary 25The minimal selective concentration for a ciprofloxacin resistant E. coli strain increases up to 26 5-fold in the presence of Zinc cations. 27 3 Abstract 28 Antimicrobial resistance (AMR) has emerged as one of the most pressing global threats to 29 public health. AMR evolution occurs in the clinic but also in the environment, where low 30 concentrations of antibiotics and heavy metals can respectively select and co-select for 31 resistance. While the selective potential for AMR of both antibiotics and metals is 32 increasingly well-characterized, studies exploring the combined effect of both types of 33 selective agents are rare. It has previously been demonstrated that fluoroquinolone 34 antibiotics such as ciprofloxacin can chelate metal ions. To investigate how ciprofloxacin 35 resistance is affected by the presence of metals, we quantified selection dynamics between 36 a ciprofloxacin-susceptible and an isogenic ciprofloxacin-resistant Escherichia coli MG1655 37 strain across a gradient of ciprofloxacin concentrations in the presence and absence of Zinc 38 cations (Zn 2+ ). The minimal selective concentration (MSC) for ciprofloxacin resistance 39 significantly increased up to 5-fold in the presence of Zn 2+ . No such effect on the MSC was 40 found for gentamicin, an antibiotic not known to chelate zinc cations. Environmental pollution 41 usually consists of complex mixtures of antimicrobial agents. Our findings highlight the 42 importance of taking antagonistic as well as additive or synergistic interactions between 43 different chemical compounds into account when considering their effect on bacterial 44 resistance evolution. 45

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Section: Introduction 46mentioning

confidence: 99%

Zinc can counteract selection for ciprofloxacin resistance

Vos

Sibleyras

et al. 2019

Preprint

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“…an antibiotic (tetracycline) to (co)select for tetracycline resistance in agricultural soil was investigated by Song et al (2017a). Soil was collected from an experimental farm in Denmark to establish soil microcosms.…”

Section: Antibiotic Resistance Genesmentioning

confidence: 99%

Detection, Occurrence and Fate of Emerging Contaminants in Agricultural Environments

Snow

Cassada

Biswas

et al. 2018

Water Environment Research

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A total of 75 papers published in 2017 were reviewed ranging from detailed descriptions of analytical methods, to fate and occurrence studies, to ecological effects and sampling techniques for a wide variety of emerging contaminants likely to occur in agricultural environments. New methods and studies on veterinary pharmaceuticals, steroids, antibiotic resistance genes, and engineered nanoparticles agricultural environments continue to expand our knowledge base on the occurrence and potential impacts of these compounds. This review is divided into the following sections: Introduction, Analytical Methods, Fate and Occurrence, Pharmaceutical Metabolites, Anthelmintics, Antibiotic Resistence Genes, and Engineered Nanomaterials.

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“…The use of antibiotics as feed additives for growth promotion in conventional husbandry was prohibited from 2006, but copper (Cu) and zinc (Zn) are still used as feed additives in high amounts. In some cases, they may exert a stronger environmental selection pressure for resistance to antibiotics of the soil microbiota than the specific antibiotic itself (Song et al 2017). …”

Section: Contribution Of Organic Farming To Public Goods Due To Very mentioning

confidence: 99%

Contribution of organic farming to public goods in Denmark

Jespersen¹,

Baggesen

Fog

et al. 2017

Org. Agr.

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The potential contribution of organic farming to the public goods, 'Nature and Biodiversity', 'Environment', 'Energy and Climate', 'Human Health and Welfare' and 'Animal Health and Welfare' in Denmark is guided and partly secured by the principles and specific requirements of the EU Organic Regulation. However, other factors, such as the production type, farm size, geographical location and-not the least-the management of the farm, also influence the contribution. Using the ban on synthetic pesticides and restricted use of antibiotics, including the requirements to compensate for and prevent such uses in organic farming, as examples, the positive and negative contributions of organic farming in relation to selected public goods were analysed. The contributions of organic farming to Nature and Biodiversity and Human and Animal Health and Welfare are mainly positive compared to conventional farming for all farm types, whilst the effects on Environment and Energy and Climate are mixed; i.e. some effects are positive and others are negative. The analysis revealed a need for further documentation and revision of the organic principles and specific organic requirementsin particular in relation to the public goods Energy and Climate, which at present are not addressed in the EU Organic Regulation. Moreover, some organic farming requirements and practices cause dilemmas; e.g. more space per animal and outdoor access improves Animal Health and Welfare but at the same time has negative effects on Environment, Energy Consumption and Climate Change. These dilemmas should be solved before OA may be fully attractive as an integrated policy measure supporting jointly several public goods objectives.

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Comparison of Metals and Tetracycline as Selective Agents for Development of Tetracycline Resistant Bacterial Communities in Agricultural Soil

Cited by 160 publications

References 50 publications

Zinc can counteract selection for ciprofloxacin resistance

Zinc can counteract selection for ciprofloxacin resistance

Detection, Occurrence and Fate of Emerging Contaminants in Agricultural Environments

Contribution of organic farming to public goods in Denmark

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