Comparison of metabolic profiles of acutely ill and short-term weight recovered patients with anorexia nervosa reveals alterations of 33 out of 163 metabolites

Föcker, Manuel; Timmesfeld, Nina; Scherag, Susann; Knoll, Nadja; Singmann, Paula; Wang-Sattler, Rui; Bühren, Katharina; Schwarte, Reinhild; Egberts, Karin; Fleischhaker, Christian; Adamski, Jerzy; Illig, Thomas; Suhre, Karsten; Albayrak, Özgür; Hinney, Anke; Hebebrand, Johannes

doi:10.1016/j.jpsychires.2012.08.015

Cited by 26 publications

(32 citation statements)

References 54 publications

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“…However, in contrast to our study, citrulline was negatively related to both BMI-SDS and future HOMA insulin resistance in that and another study in youth [10,23]. Rapid weight gain was also associated with levels of PCaaC34:4 in a longitudinal study in adolescent anorexia patients [9]. We could not identify further studies showing this effect either in youth or in younger children.…”

Section: Discussioncontrasting

confidence: 99%

“…Our finding of a positive relation of tyrosine with rapid growth is in line with the results of one of the few longitudinal studies on metabolic profiles in youth which showed elevated levels of tyrosine after a quick weight recovery for adolescent anorexia patients [9]. A small study in healthy prepubertal and pubertal children with a focus on analysis of fasting circulating concentrations of branched-chain amino acids and potential insulin resistance 18 months after enrolment gave further, though indirect, plausibility to our finding by showing a positive correlation with fasting BMI-SDS and a greater effect on future HOMA insulin resistance not far from significance [23].…”

Section: Discussionsupporting

confidence: 89%

“…A few studies have applied a targeted metabolomics approach for the analysis of obesity or weight change in child or adolescent populations [9,10,11,12]. These publications have mainly been based on small case-control studies of obese and normal-weight children, with a maximum of 160 participants in late childhood or adolescence from clinical settings or even very special populations like anorexic patients [9].…”

Section: Introductionmentioning

confidence: 99%

“…These publications have mainly been based on small case-control studies of obese and normal-weight children, with a maximum of 160 participants in late childhood or adolescence from clinical settings or even very special populations like anorexic patients [9]. The metabolic profile of weight change has therefore only been assessed in the context of obesity or anorexia treatment, resulting in the analysis of weight loss [12] and weight regain [9], and not in unselected populations.…”

Section: Introductionmentioning

confidence: 99%

“…The metabolic profile of weight change has therefore only been assessed in the context of obesity or anorexia treatment, resulting in the analysis of weight loss [12] and weight regain [9], and not in unselected populations. Thus, the metabolic profile of anorexic patients with a mean age of about 15 years [9] is quite different and comprises more metabolites from more species than those found in studies on obese versus normal-weight children and adolescents with an age range of 6-16 years [11,12]. …”

Section: Introductionmentioning

confidence: 99%

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Rapid Growth and Childhood Obesity Are Strongly Associated with LysoPC(14:0)

Rzehak

Hellmuth²,

Uhl³

et al. 2014

Ann Nutr Metab

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Background: Despite the growing interest in the early-origins-of-later-disease hypothesis, little is known about the metabolic underpinnings linking infant weight gain and childhood obesity. Objective: To discover biomarkers reflective of weight change in the first 6 months and overweight/obesity at age 6 years via a targeted metabolomics approach. Design: This analysis comprised 726 infants from a European multicenter randomized trial (Childhood Obesity Programme, CHOP) for whom plasma blood samples at age 6 months and anthropometric data up to the age of 6 years were available. ‘Rapid growth' was defined as a positive difference in weight within the first 6 months of life standardized to WHO growth standards. Weight change was regressed on each of 168 metabolites (acylcarnitines, lysophosphatidylcholines, sphingomyelins, and amino acids). Metabolites significant after Bonferroni's correction were tested as predictors of later overweight/obesity. Results: Among the overall 19 significant metabolites, 4 were associated with rapid growth and 15 were associated with a less-than-ideal weight change. After adjusting for feeding group, only the lysophosphatidylcholine LPCaC14:0 remained significantly associated with rapid weight gain (β = 0.18). Only LPCaC14:0 at age 6 months was predictive of overweight/obesity at age 6 years (OR 1.33; 95% CI 1.04-1.69). Conclusion: LPCa14:0 is strongly related to rapid growth in infancy and childhood overweight/obesity. This suggests that LPCaC14:0 levels may represent a metabolically programmed effect of infant weight gain on the later obesity risk. However, these results require confirmation by independent cohorts.

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Section: Discussioncontrasting

confidence: 99%

Section: Discussionsupporting

confidence: 89%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Rapid Growth and Childhood Obesity Are Strongly Associated with LysoPC(14:0)

Rzehak

Hellmuth²,

Uhl³

et al. 2014

Ann Nutr Metab

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Inpatient versus outpatient care, partial hospitalisation and waiting list for people with eating disorders

Hay

Touyz

Claudino

et al. 2019

Cochrane Database of Systematic Reviews

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Analysis 1.2. Comparison 1 Specialist inpatient (IP) care for weight restoration in anorexia nervosa versus active outpatient (OP) or combined brief hospital and outpatient care, Outcome 2 Acceptibility: number of participants who completed treatment...... Analysis 1.3. Comparison 1 Specialist inpatient (IP) care for weight restoration in anorexia nervosa versus active outpatient (OP) or combined brief hospital and outpatient care, Outcome 3 Clinical response: end of treatment weight restoration to within the normal range..

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Serum metabolic signature of binge‐like palatable food consumption in female rats by nuclear magnetic resonance spectroscopy

et al. 2021

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Maladaptive eating behavior is a growing public health problem and compulsively eating excessive food in a short time, or binge eating, is a key symptom of many eating disorders. In order to investigate the binge‐like eating behavior in female rats, induced by intermittent food restrictions/refeeding and frustration stress, we analyzed for the first time the metabolic profile obtained from serum of rats, through nuclear magnetic resonance (NMR) spectroscopy. In this experimental protocol, rats were exposed to chow food restricting/refeeding and frustration stress manipulation. This stress procedure consists of 15 min exposure to the odor and sight of a familiar chocolate paste, without access to it, just before offering the palatable food. In this model, a “binge‐eating episode” was considered the significantly higher palatable food consumption within 2 h in restricted and stressed rats (R + S) than in the other three experimental groups: rats with no food restriction and no stress (NR + NS), only stressed rats (NR + S) or only restricted rats (R + NS). Serum samples from these four different rat groups were collected. The statistical analysis of the 1H NMR spectral profiles of the four sets of samples pointed to O‐ and N‐acetyl glycoproteins as the main biomarkers for the discrimination of restriction effects. Other metabolites, such as threonine, glycine, glutamine, acetate, pyruvate and lactate, showed trends that may be useful to understand metabolic pathways involved in eating disorders. This study suggested that NMR‐based metabolomics is a suitable approach to detect biomarkers related to binge‐eating behavior.

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Comparison of metabolic profiles of acutely ill and short-term weight recovered patients with anorexia nervosa reveals alterations of 33 out of 163 metabolites

Cited by 26 publications

References 54 publications

Rapid Growth and Childhood Obesity Are Strongly Associated with LysoPC(14:0)

Rapid Growth and Childhood Obesity Are Strongly Associated with LysoPC(14:0)

Inpatient versus outpatient care, partial hospitalisation and waiting list for people with eating disorders

Serum metabolic signature of binge‐like palatable food consumption in female rats by nuclear magnetic resonance spectroscopy

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