Comparison of MET-PET and FDG-PET for differentiation between benign lesions and lung cancer in pneumoconiosis

Kanegae, Kakuko; Nakano, Ikuo; Kimura, Kazuhiro; Kaji, Hiroshi; Kuge, Yuji; Shiga, Tohru; OKAMOTO, Shiki; Tamaki, Nagara

doi:10.1007/s12149-007-0035-x

Cited by 22 publications

(10 citation statements)

References 8 publications

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“…The SUV in the granuloma was significantly lower than that in the tumor (Fig. 6c), which is consistent with the previous reports [15,30]. Thus, the dynamic pattern of 11 C-MET uptake was significantly different between tumors and granulomas.…”

Section: Discussionsupporting

confidence: 91%

“…Our clinical study [15] also showed that the SUV max of 11 C-MET was significantly higher in lung cancer than in the pneumoconiotic nodules. Inflammatory processes, however, can result in an increased uptake level of 11 C-MET in certain brain regions after stereotactic radiosurgery and be mistaken for residual tumor tissue [16].…”

Section: Introductionsupporting

confidence: 64%

“…Our previous clinical study [15] also showed that 11 C-MET accumulates not only in malignant lesions but also in benign pneumoconiotic nodules, although the SUV max of 11 C-MET was significantly higher in lung cancer than in the pneumoconiotic nodules. Taken together, in such clinical situations, dynamic 11 C-MET PET can be more suitable than conventional static 11 C-MET PET for differentiating malignant tumors from granulomatous lesions.…”

Section: Discussionmentioning

confidence: 80%

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Supercontinent dynamics

Santosh¹,

Zhao²

2009

Gondwana Research

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Purpose: We evaluated whether the dynamic profile of 11 C-MET may have an additional value in differentiating malignant tumors from granulomas in experimental rat models by small-animal PET.Methods: Rhodococcus aurantiacus and allogenic rat C6-glioma cells were inoculated respectively into the right and left calf muscles to generate a rat model bearing both granulomas and tumors (n=6). Ten days after the inoculations, dynamic 11 C-MET PET was performed by small-animal PET up to 120 min after injection of 11 C-MET. The next day, after overnight fasting, the rats were injected with 18 F-FDG, and dynamic 18 F-FDG PET was performed up to 180 min. The time-activity curves, static images, and mean standardized uptake value (SUV) in the lesions were calculated. Results:11 C-MET uptake in the granuloma showed a slow exponential clearance after an initial distribution, while the uptake in the tumor gradually increased with time. The dynamic pattern of 11 C-MET uptake in the granuloma was significantly different from that in the tumor (p<0.001). In the static analysis of 11 C-MET, visual assessment and SUV analysis could not differentiate the tumor from the granuloma in all cases, although the mean SUV in the granuloma (1.48 ± 0.09) was significantly lower than that in the tumor (1.72 ± 0.18, p < 0.01). The dynamic patterns, static images, and mean SUVs of 18 F-FDG in the granuloma were similar to those in the tumor (p=ns). Conclusions: Dynamic 11C-MET PET has an additional value for differentiating malignant tumors from 3 granulomatous lesions, which deserve further elucidation in clinical settings.

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Section: Discussionsupporting

confidence: 91%

Section: Introductionsupporting

confidence: 64%

Section: Discussionmentioning

confidence: 80%

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Supercontinent dynamics

Santosh¹,

Zhao²

2009

Gondwana Research

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“…It was reported the 18 F-FDG and 11 C-methionine have sensitivity of 60% and 80% and specificity of 100% and 93%, respectively, for identification of lung cancer. 81 As stated earlier, it has been reported that dualtime point 18 F-FDG-PET can provide better discrimination of benign and malignant lung nodules and pleural changes when compared with that using structural imaging. 72,82 Thus, FDG-PET might have some role in pneumoconiosis diagnostic or prognostic monitoring, but much more clinical evaluation is required.…”

Section: Nononcologic Applicationsmentioning

confidence: 81%

PET/MRI and PET/CT in Lung Lesions and Thoracic Malignancies

Flechsig

Mehndiratta

Haberkorn

et al. 2015

Seminars in Nuclear Medicine

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“…In a comparative study of the ability of C 11 methionine (MET) and FDG-PET to diagnose lung cancer in patients with pneumoconiosis, Kanegae et al [19] examined 26 subjects who underwent both whole-body MET-PET and FDG-PET on the same day. The first group was a lung cancer group, which consisted of 15 patients, including those with pneumoconiosis with multiple nodules (13 cases), hemoptysis (one case), and positive sputum cytology (one case).…”

Section: Occupational Pleuropulmonary Disordersmentioning

confidence: 99%

Clinical Utility of FDG–PET and PET/CT in Non-malignant Thoracic Disorders

et al. 2010

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There have been several endeavors made to investigate the potential role of 2-deoxy-2-[(18)F]fluoro-D-glucose positron emission tomography (FDG-PET) (and tracers) and PET-computed tomography imaging in various benign disorders, particularly those related to thoracic structures. These various conditions can be broadly categorized into three groups: (a) infectious diseases (mycobacterial, fungal, bacterial infection), (b) active granulomatous disease such as sarcoidosis, and (c) other non-infectious/inflammatory conditions or proliferative disorders (e.g., radiation pneumonitis, post-lung transplant lymphoproliferative disorders, occupational pleuropulmonary complications, and post-surgical conditions), all of which can demonstrate varying degrees of FDG uptake on PET scans based upon the degree of inflammatory activity. This article reviews the current state of this very important application of FDG-PET imaging.

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Comparison of MET-PET and FDG-PET for differentiation between benign lesions and lung cancer in pneumoconiosis

Abstract: Our results indicate that nodules with an intense uptake of MET and FDG relative to their size should be carefully observed because of a high risk for lung cancer.

Cited by 22 publications

References 8 publications

Supercontinent dynamics

Supercontinent dynamics

PET/MRI and PET/CT in Lung Lesions and Thoracic Malignancies

Clinical Utility of FDG–PET and PET/CT in Non-malignant Thoracic Disorders

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