Aim: The aim of this study was to investigate the effect of preheating of inlay and onlay restorations prepared from composite materials and using a CAD/CAM device on microtensile bond strength in different structures. Methodology: 90 impacted human third molar teeth were used. These teeth were divided into 3 groups. MOD inlay cavity preparation was performed. For the first group, restorations were prepared using a CAD/CAM device. For the second group, a fiber-reinforced composite (EverX Posterior, GC, Tokyo, Japan) was used and restoration was then completed using the laboratory composite system (Gradia, GC, Tokyo, Japan). For the third group, laboratory composite system (Gradia, GC, Tokyo, Japan) was used alone. Er,Cr:YSGG laser (Fotona Laser AT Fidelis Plus III, Slovenia) was administered on all prepared restorations. In the cementation of the restorations, resin cement was administered with and without preheating. The prepared samples were tested for microtensile bond strength (Microtensile Tester, Bisco, Schaumburg, IL, USA). Results: There was no statistically significant difference between the groups of the microtensile bond strengths of the samples in which the adhesive cement was pre-heated (P) and not pre-heated (N) (p>0.05). There was a statistically significant difference (p<0.05) in terms of the microtensile bond strength values between the groups in which the adhesive cement was pre-heated during the cementation of restorations. Conclusions: It was observed that exposure of the adhesive cement to preheating in the cementation of the EverX Posterior-based inlays adversely affects the bond strength. The preheating process statistically significantly increased the bond strength in the inlays made using the Gradia composite. Preheating of the cement in the cementation of Cerasmart composite inlays produced using the CAD/CAM system did not affect the microtensile bond strength. The effect of preheating process on microtensile bond strength Görüş Z.