Comparison of mechanical allodynia and the affective component of inflammatory pain in rats

Boyce-Rustay, Janel M.; Zhong, Chengmin; Kohnken, Rebecca; Baker, Scott J.; Simler, Gricelda H.; Wensink, Erica J.; Decker, Michael; Honoré, Prisca

doi:10.1016/j.neuropharm.2009.08.008

Cited by 46 publications

(46 citation statements)

References 37 publications

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“…This is not surprising in view of the recognized low efficacy of NSAIDs against centralized neuropathic pain [14], [15] and supports the supposition that central sensitization occurs in feline OA-associated chronic pain, similar to humans [15], [20], [21], [23]. While the vFWT was also reliable in OA cats [10], this is primarily only a reflexive evaluation of hypersensitivity [38], [39]. In contrast, evaluation of TS provides the opportunity to evaluate central sensitization with conscious perception since it is based on pain behaviour, implying cortical integration.…”

Section: Discussionsupporting

confidence: 64%

Evoked Temporal Summation in Cats to Highlight Central Sensitization Related to Osteoarthritis-Associated Chronic Pain: A Preliminary Study

Guillot

Taylor²,

Rialland

et al. 2014

PLoS ONE

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In cats, osteoarthritis causes significant chronic pain. Chronicity of pain is associated with changes in the central nervous system related to central sensitization, which have to be quantified. Our objectives were 1) to develop a quantitative sensory testing device in cats for applying repetitive mechanical stimuli that would evoke temporal summation; 2) to determine the sensitivity of this test to osteoarthritis-associated pain, and 3) to examine the possible correlation between the quantitative sensory testing and assessment using other pain evaluation methods. We hypothesized that mechanical sub-threshold repetitive stimuli would evoke temporal summation, and that cats with osteoarthritis would show a faster response. A blinded longitudinal study was performed in 4 non-osteoarthritis cats and 10 cats with naturally occurring osteoarthritis. Quantification of chronic osteoarthritis pain-related disability was performed over a two week period using peak vertical force kinetic measurement, motor activity intensity assessment and von Frey anesthesiometer-induced paw withdrawal threshold testing. The cats afflicted with osteoarthritis demonstrated characteristic findings consistent with osteoarthritis-associated chronic pain. After a 14-day acclimation period, repetitive mechanical sub-threshold stimuli were applied using a purpose-developed device. Four stimulation profiles of predetermined intensity, duration and time interval were applied randomly four times during a four-day period. The stimulation profiles were different (P<0.001): the higher the intensity of the stimulus, the sooner it produced a consistent painful response. The cats afflicted with osteoarthritis responded more rapidly than cats osteoarthritis free (P = 0.019). There was a positive correlation between the von Frey anesthesiometer-induced paw withdrawal threshold and the response to stimulation profiles #2 (2N/0.4 Hz) and #4 (2N/0.4 Hz): Rhos = 0.64 (P = 0.01) and 0.63 (P = 0.02) respectively. This study is the first report of mechanical temporal summation in awake cats. Our results suggest that central sensitization develops in cats with naturally occurring osteoarthritis, providing an opportunity to improve translational research in osteoarthritis-associated chronic pain.

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Section: Discussionsupporting

confidence: 64%

Evoked Temporal Summation in Cats to Highlight Central Sensitization Related to Osteoarthritis-Associated Chronic Pain: A Preliminary Study

Guillot

Taylor²,

Rialland

et al. 2014

PLoS ONE

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“…In addition, CFA-treated rats can also develop behavioral despair, another feature of depression [52, 53]. Finally, inflammatory pain has been shown to induce place avoidance in rats [54, 55]. In this test, rats stayed away from the chamber associated with inflammatory pain, suggesting that pain serves as an aversive stimulus that the rats actively avoid.…”

Section: Animal Models For the Study Of Pain And Depressionmentioning

confidence: 99%

Neuroplasticity Underlying the Comorbidity of Pain and Depression

2015

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Acute pain induces depressed mood, and chronic pain is known to cause depression. Depression, meanwhile, can also adversely affect pain behaviors ranging from symptomology to treatment response. Pain and depression independently induce long-term plasticity in the central nervous system (CNS). Comorbid conditions, however, have distinct patterns of neural activation. We performed a review of the changes in neural circuitry and molecular signaling pathways that may underlie this complex relationship between pain and depression. We also discussed some of the current and future therapies that are based on this understanding of the CNS plasticity that occurs with pain and depression.

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“…Although it has been demonstrated to be effective in inflammation [17], we cannot exclude the notion that in our setting, it did not penetrate the skin sufficiently. In particular, the CFA pain model was reported to require up to 10Â higher NSAID doses [6] or chronic treatment [4] to demonstrate ketorolac sensitivity. This might be attributed to model singularities.…”

Section: Local Topical Application Of Bibn4096bs Reduces Wdr Neuronalmentioning

confidence: 99%

The CGRP receptor antagonist BIBN4096BS peripherally alleviates inflammatory pain in rats

Hirsch

Corradini

Just

et al. 2013

Pain

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Calcitonin gene-related peptide (CGRP) is known to play a major role in the pathogenesis of pain syndromes, in particular migraine pain. Here we focus on its implication in a rat pain model of inflammation, induced by injection of complete Freund adjuvant (CFA). The nonpeptide CGRP receptor antagonist BIBN4096BS reduces migraine pain and trigeminal neuronal activity. Here we demonstrate that the compound reduces inflammatory pain and spinal neuronal activity. Behavioural experiments reveal a reversal of the CFA-induced mechanical hypersensitivity and monoiodoacetate (MIA)-induced weight-bearing deficit in rats after systemic drug administration. To further investigate the mechanism of action of the CGRP antagonist in inflammatory pain, in vivo electrophysiological studies were performed in CFA-injected rats. Recordings from wide dynamic range neurons in deep dorsal horn layers of the lumbar spinal cord confirmed a reduction of neuronal activity after systemic drug application. The same amount of reduction occurred after topical administration onto the paw, with resulting systemic plasma concentrations in the low nanomolar range. However, spinal administration of BIBN4096BS did not modify the neuronal activity in the CFA model. Peripheral blockade of CGRP receptors by BIBN4096BS significantly alleviates inflammatory pain.

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Comparison of mechanical allodynia and the affective component of inflammatory pain in rats

Cited by 46 publications

References 37 publications

Evoked Temporal Summation in Cats to Highlight Central Sensitization Related to Osteoarthritis-Associated Chronic Pain: A Preliminary Study

Evoked Temporal Summation in Cats to Highlight Central Sensitization Related to Osteoarthritis-Associated Chronic Pain: A Preliminary Study

Neuroplasticity Underlying the Comorbidity of Pain and Depression

The CGRP receptor antagonist BIBN4096BS peripherally alleviates inflammatory pain in rats

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