Comparison of maternal and fetal health outcomes in the pandemic period of covid-19 with the same last year duration in health centers of second largest city of Iran: A population-based cohort study

Davaryari, Neda; Davaryar, Saeed; Vakili, Veda; Azarshab, Adele; Vakilzadeh, Mohammad Moein; Moazzeni, Zahra

doi:10.1016/j.heliyon.2023.e14439

Cited by 3 publications

(4 citation statements)

References 17 publications

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Section: Discussionmentioning

confidence: 99%

“…Regarding fetal outcomes, our data seem to be in contrast with the obstetric literature, since we found no correlation between maternal COVID-19 and adverse fetal or neonatal outcomes. Instead, in the general population, the infection appears to be associated with higher risk for severe neonatal mortality and morbidity, [17][18][19][20][21] including respiratory distress (OR = 1.66), low birth weight (OR = 1.69), stillbirth (OR = 1.46), and NICU admission (OR = 2.12). 8 To explain this difference, as speculated in other studies assessing COVID-19 outcomes in pregnant patients with MS, 9,22 we can hypothesize a role of the more intensive specialized care received by MS pregnant patients, considered and treated as "high-risk" pregnancies.…”

Section: Discussionmentioning

confidence: 99%

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Impact of COVID-19 on pregnancy and fetal outcomes in women with multiple sclerosis

Aprea,

Schiavetti,

Portaccio

et al. 2024

Mult Scler

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Background: In the general population, maternal COVID-19 is associated with worse maternal and fetal outcomes. Two previous studies have assessed COVID-19 clinical outcomes in pregnant women with multiple sclerosis (MS), but there are no data about maternal and fetal outcomes. Objectives: In this multicenter study, we aimed to assess maternal and fetal outcomes in pregnant women with MS and COVID-19 infection. Methods: We recruited pregnant patients with MS who contracted COVID-19 and were followed up in Italian and Turkish Centers, during 2020–2022. A control group was extracted from a previous Italian cohort. Associations between group (COVID-19 or healthy patients) and clinical outcomes (maternal complications, fetal malformations, and spontaneous abortion) were investigated with a weighted logistic regression where propensity score–based inverse probability of treatment weighting (IPTW) approach was applied for adjusting for difference in baseline confounders. Results: In the multivariable analysis, COVID-19 during pregnancy was associated with a higher risk of maternal complications (odd ratio (OR) = 2.12; 95% confidence interval (CI) = 1.32–3.48; p = 0.002), while it was not associated with higher risk of spontaneous abortion and fetal malformations. Conclusion: Our data indicate that COVID-19 during pregnancy increases the risk of maternal complications, while it seems to have no significant impact on fetal outcomes.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Impact of COVID-19 on pregnancy and fetal outcomes in women with multiple sclerosis

Aprea,

Schiavetti,

Portaccio

et al. 2024

Mult Scler

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“…2 The COVID-19 pandemic has brought significant changes to various aspects of life, including maternal and fetal health outcomes. 3 Consequently, protecting pregnant women and their infants from COVID-19 has become a public health priority.…”

Section: Introductionmentioning

confidence: 99%

“…Pregnant women have been identified as a vulnerable group due to the physiological changes in their immune and respiratory systems, making them more susceptible to severe complications from COVID‐19 infection 2 . The COVID‐19 pandemic has brought significant changes to various aspects of life, including maternal and fetal health outcomes 3 . Consequently, protecting pregnant women and their infants from COVID‐19 has become a public health priority.…”

Section: Introductionmentioning

confidence: 99%

Investigating the impact of Sinopharm COVID‐19 vaccination on antibody response in pregnant women and their newborns

Abdolahi,

Maamouri,

Behmadi

et al. 2023

Journal of Medical Virology

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This study aims to investigate the levels of receptor‐binding domain (RBD), spike, and neutralizing antibodies in pregnant women who received the Sinopharm vaccine and their newborns. A cross‐sectional study was conducted at a tertiary center, Mashhad, Iran. We included 88 pregnant women who had received at least two doses of the Sinopharm vaccine. Maternal and umbilical cord blood samples taken at delivery were analyzed for antibodies using ELISA tests. Antibody levels did not vary significantly between women with two or three vaccine doses. Only 1.1% of mothers had undetectable levels of RBD antibodies, but detectable antibodies were observed in all newborns. A significant linear correlation was found between the levels of neutralizing antibodies (r = 0.7, p < 0.001) and RBD antibodies (r = 0.833, p < 0.001) in mothers and their newborns, but not for Spike antibodies (r = 0.214, p = 0.045). In mothers, high titers of antispike and RBD antibodies were observed at the time of delivery. The high titers of RBD and antispike antibodies were found in cord blood, suggesting potential neonatal immunity. Detectable levels of antibodies were found in both groups, regardless of the timing of vaccination. The Sinopharm vaccine generates detectable levels of antibodies in pregnant women, which are efficiently transferred to their newborns. The number of vaccine doses (two or three) did not significantly impact the levels of detectable antibodies. This underscores Sinopharm's potential efficacy in protecting pregnant women and their infants from COVID‐19.

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Investigating the Rate of Premature Delivery and Low Birth Weight in Mothers With Covid-19 Hospitalized in Kausar Urmia Hospital in 1400 and Comparing It With the Population of Non-Infected Mothers

Broumand Sorkhabi,

Vazifekhah,

Esmailzadeh

2024

Studies in Medical Sciences

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Comparison of maternal and fetal health outcomes in the pandemic period of covid-19 with the same last year duration in health centers of second largest city of Iran: A population-based cohort study

Cited by 3 publications

References 17 publications

Impact of COVID-19 on pregnancy and fetal outcomes in women with multiple sclerosis

Impact of COVID-19 on pregnancy and fetal outcomes in women with multiple sclerosis

Investigating the impact of Sinopharm COVID‐19 vaccination on antibody response in pregnant women and their newborns

Investigating the Rate of Premature Delivery and Low Birth Weight in Mothers With Covid-19 Hospitalized in Kausar Urmia Hospital in 1400 and Comparing It With the Population of Non-Infected Mothers

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