Comparison of maternal and fetal blood levels of caffeine and its metabolite. A pilot study

Wierzejska, Regina; Jarosz, M.; Siuba, Magdalena; Sawicki, Włodzimierz

doi:10.17772/gp/1760

Cited by 11 publications

(9 citation statements)

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“…Most (61.7%) pregnant women from the study by Alomar et al also consumed 200 mg of caffeine per day, and daily intake over 400 mg/day was found in only 6.25% of the cases [ 22 ]. Evaluation of caffeine intake during pregnancy is particularly important due to its unrestricted passage across the placental barrier [ 29 ]. Various factors affect health decisions made daily by pregnant women, among them education, which is not consistent with our findings or the study by Pieniążek et al [ 26 ].…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Caffeine Consumption among Pregnant Women from Southern Poland

Błaszczyk-Bębenek

Piórecka

Kopytko

et al. 2018

IJERPH

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Caffeine is the most widely consumed stimulant worldwide, including by pregnant women. Products containing caffeine should be limited in accordance with the recommendations for pregnancy. The purpose of this study was to evaluate consumption of caffeinated products and daily caffeine intake from food by pregnant women. The study was conducted on a group of healthy pregnant women: attendees of antenatal classes (n = 70) and patients of an outpatient gynecological clinic (n = 70) from Krakow (Southern Poland). A questionnaire about the frequency of consumption of selected foods and drinks containing caffeine was used. The average caffeine content in food products obtained from other Polish studies was used to estimate average daily caffeine intake in our study group. Mean daily caffeine intake was 49.60 ± 59.15 mg/day and the maximum was 498.0 mg/day. The main sources of caffeine were as follows: black tea (bags, leaf), instant coffee and ground coffee. No statistically significant differences in caffeine intake between the groups were found. A weak negative correlation (rs) = −0.28 (p = 0.0208) between month of pregnancy and caffeine intake was observed among attendees of antenatal classes. Mean daily caffeine intake did not exceed the maximum recommended dose in our study group.

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Section: Discussionmentioning

confidence: 99%

Evaluation of Caffeine Consumption among Pregnant Women from Southern Poland

Błaszczyk-Bębenek

Piórecka

Kopytko

et al. 2018

IJERPH

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“…The caffeine-induced increase in catecholamine concentrations (adrenaline, dopamine, and serotonin) interferes with placental blood flow and hampers transplacental nutrient transport to the fetus [6,7]. Caffeine and its metabolites easily cross the placental barrier [2,3,8], and caffeine excretion is delayed due to the immaturity of the fetal liver [2,9].…”

Section: Introductionmentioning

confidence: 99%

Caffeine Intake During Pregnancy and Neonatal Anthropometric Parameters

Wierzejska¹,

Jarosz²,

Wojda³

2019

Nutrients

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Caffeine is a psychoactive substance that may affect the normal course of pregnancy, therefore its intake during that time should not exceed 200 mg/day. The aim of this study was to evaluate caffeine intake among pregnant women from the Warsaw region. The study was conducted among 100 pregnant women who delivered at the Department of Obstetrics, Gynecology and Oncology, Medical University of Warsaw. Caffeine intake from coffee, tea, and energy drinks was measured using a questionnaire. Direct interviewing was used, with all interviews conducted by the same dietitian. Multiple regression analysis was used to investigate the relationship between caffeine intake and anthropometric measurements of the newborns. Mean caffeine intake among pregnant women was 68 ± 51 mg/day. Only 2% of the respondents exceeded the safe dose of 200 mg. Tea (mostly black) was the source of 63% of all caffeine. No relationships were found between caffeine intake and neonatal weight, length, or head and chest circumference (p > 0.05). Caffeine intake in our study population was relatively low and did not negatively affect fetal growth.

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“…None of these authors [14,28,35] examined the metabolic activity of microsomal systems, as we did in the present study; perhaps genetic and environmental characteristics in their study population, and ours, may have influenced the results.. We evaluated both CYP1A2 and CYP2E1, the two major caffeine metabolizers in humans, and their variation in the study population. Overall, the frequency of CYP1A2 * 1F alleles (rs762551) was found to be similar to that of other American ancestry, with strong similitude to that of a Chilean mestizo cohort and slightly higher than the Costa Rican and Japanese population [36,37], but significantly different from the population of Africa, East Asia, European ancestry, and South Asia [22] (see Tables 3 and 4).…”

Section: Discussionmentioning

confidence: 85%

Modulation of CYP2E1 metabolic activity in a cohort of confirmed caffeine ingesting pregnant women with preterm offspring

et al. 2020

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Background To ascertain interactions of caffeine ingestion, food, medications, and environmental exposures during preterm human gestation, under informed consent, we studied a cohort of Mexican women with further preterm offspring born at ≤ 34 completed weeks. At birth, blood samples were taken from mothers and umbilical cords to determine caffeine and metabolites concentrations and CYP1A2 (rs762551) and CYP2E1 (rs2031920, rs3813867) polymorphisms involved in caffeine metabolism. Results In 90 pregnant women who gave birth to 98 preterm neonates, self-informed caffeine ingestion rate was 97%, laboratory confirmed rate was 93 %. Theobromine was the predominant metabolite found. Consumption of acetaminophen correlated significantly with changes in caffeine metabolism (acetaminophen R2 = 0.637, p = 0.01) due to activation of CYP2E1 alternate pathways. The main caffeine source was cola soft drinks. Conclusion Environmental exposures, especially acetaminophen ingestion during human preterm pregnancy, can modulate CYP2E1 metabolic activity.

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Comparison of maternal and fetal blood levels of caffeine and its metabolite. A pilot study

Cited by 11 publications

References 0 publications

Evaluation of Caffeine Consumption among Pregnant Women from Southern Poland

Evaluation of Caffeine Consumption among Pregnant Women from Southern Poland

Caffeine Intake During Pregnancy and Neonatal Anthropometric Parameters

Modulation of CYP2E1 metabolic activity in a cohort of confirmed caffeine ingesting pregnant women with preterm offspring

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