Comparison of Marlex Mesh and microporous teflon sheets when used for hernia repair in the experimental animal

Elliott, Martin P.; Juler, George L.

doi:10.1016/0002-9610(79)90063-1

Cited by 83 publications

(26 citation statements)

References 6 publications

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“…Although Gore-Tex has been found to in duce adhesions in our experimental model, it should be noted that such a side effect is not prominent in humans [4,11], Such contro versy is supported by Jenkins et al [12] who has reported moderate to marked adhesions in the rat whereas other authors [13,14] have presented excellent results in the rabbit. Therefore, there may be species differences in reference to the reaction to specific prosthetic materials.…”

Section: ]supporting

confidence: 59%

A Comparison of Intraperitoneal Prostheses for the Repair of Abdominal Muscular Wall Defects in Rats

Pans

Piérard

1992

Eur Surg Res

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We compared the tissue response to the intraperitoneal implantation of three different prostheses (Gore-Tex®, Mersilène®, Vicryl-Mersilène) used to repair abdominal wall defects in rats. Vicryl-Mersilène is a new experimental prosthesis made of Dacron (Mersilène) coated with absorbable polyglactin (Vicryl®). The least amount of adhesions to omentum and gut was found with Mersilène. Gore-Tex was responsible for the accumulation of neutrophils rather than macrophages mostly collected in close contact with Mersilène and Vicryl-Mersilène. Fibrosis, evaluated by histology and computerized morphometry, was mostly found with Vicryl-Mersilène. This should allow a better incorporation of Mersilène and a tighter anchorage to the abdominal wall, after Vicryl resorption.

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Section: ]supporting

confidence: 59%

A Comparison of Intraperitoneal Prostheses for the Repair of Abdominal Muscular Wall Defects in Rats

Pans

Piérard

1992

Eur Surg Res

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“…Moreover, as the number of macro phages decreases, the number of fibroblasts around the Marlex microfilaments rises, indi cating an increase in the amount of newly formed connective tissue. These findings are in agreement with those obtained by Baird et al [9] who reported that the macrophages produce basic fibroblast growth factor, but contradict the data of Elliot and Juler [10] when they affirm that the incorporation of tissue into polypropylene implants is finished by 8 weeks after implantation. Although monoclonal anti body labeling indicates a reduction in the num ber of macrophages, this does not signify that there is not a strong foreign-body reaction towards the biomaterial during the entire assay period.…”

supporting

confidence: 91%

“…By contrast, the number of macrophages falls by 80% with respect to the 2-week stage. According to Elliot and Juler [10], the continuous foreign-body reaction would displace the Marlex implant from its anatomical position. We have not observed this event, nor have we detected changes in the adjacent tissue due to the prosthesis.…”

mentioning

confidence: 99%

Macrophage Response to Experimental Implantation of Polypropylene Prostheses

et al. 1994

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We have assessed the macrophage response to polypropylene mesh (Marlex®) implanted into the abdominal wall of New Zealand white rabbits, using RAM-11 a monoclonal antibody specific for rabbit macrophages. The response diminishes during the course of the first 90 days after implantation, although the presence of other cell tpyes typical of foreign-body reactions increases. We have also confirmed the high degree of integration of the biomaterial into the wall achieved after 9 weeks. This has been determined using light and scanning electron microscopy. Likewise, we have observed the formation of numerous adhesions between the polypropylene mesh and the viscera of the abdominal cavity.

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“…Also as noted above, in vitro studies have shown that IFN-'y down-regulates collagen and fibronectin synthesis (16)(17)(18) and this decreased synthesis is associated with decreased levels of mRNA (19)(20)(21). Fibrous capsule formation around alloplastic implants in humans and animals, including breast implants (38,39), silicone plates (40), Marlex mesh (41), and nylon velour pouches (42) has been observed previously. Our finding that a similar phenomenon occurs with the osmotic pumps allowed us to develop an in vivo model for soluble mediator effects on new collagen synthesis.…”

Section: Discussionmentioning

confidence: 66%

Gamma-interferon inhibits collagen synthesis in vivo in the mouse.

Granstein¹,

Murphy²,

Margolis³

et al. 1987

J. Clin. Invest.

166

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Subcutaneous implantation of osmotic pumps into CAF1 mice resulted in the formation of thick fibrous capsules around the pumps. When pumps were loaded with recombinant murine gamma-interferon (rMuIFN-'y) to deliver 2 X 103 U/h for 14 d, there was a marked decrease in thickness and collagen content of the capsules from rMuIFN-'y-treated animals compared with capsules from animals receiving diluent alone. The collagen content of the capsules was estimated by hydroxyproline analysis of the tissue and by quantitative electron microscopy of collagen bundles. Heat-inactivated rMuIFN-'y failed to reduce the fibrotic response in this assay. These results provide compelling evidence that gamma-interferon can down-regulate collagen synthesis in vivo and suggest the possibility that this lymphokine may be useful in the treatment of disease states characterized by excessive fibrosis.

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Comparison of Marlex Mesh and microporous teflon sheets when used for hernia repair in the experimental animal

Cited by 83 publications

References 6 publications

A Comparison of Intraperitoneal Prostheses for the Repair of Abdominal Muscular Wall Defects in Rats

A Comparison of Intraperitoneal Prostheses for the Repair of Abdominal Muscular Wall Defects in Rats

Macrophage Response to Experimental Implantation of Polypropylene Prostheses

Gamma-interferon inhibits collagen synthesis in vivo in the mouse.

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