Comparison of markers for fetal inflammatory response syndrome: Fetal blood interleukin‐6 and neonatal urinary β<sub>2</sub>‐microglobulin

Nishimaki, Shigeru; Sato, Miho; An, Hiromi; Shima, Yoshio; Akaike, Toru; Yokoyama, Utako; Yokota, Shumpei

doi:10.1111/j.1447-0756.2008.00988.x

Cited by 23 publications

(24 citation statements)

References 22 publications

(19 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It is worthwhile to note, however, that even with no observable cytokine migration during late gestation, maternal infection during this period still results in an increase in cytokine levels in the fetal CNS as there have been observations of increased cytokine mRNA and protein levels, as well as other immunological disruptions in FIRS infants [54,59,78,154] . Additionally, observations in models of MIA mimic FIRS findings of increased inflammatory cytokines and other immunological events in the fetal CNS in response to maternal injection, including the induction of monocyte chemoattractant protein-1 and increased glial cell reactivity [156,157] .…”

Section: Mia and The Placental Barriermentioning

confidence: 99%

“…Despite these studies, there is still disagreement as to whether or not these maternal cytokines, produced during maternal infection, can traverse the placental barrier and disrupt normal fetal development. Research in FIRS has shown that in instances of maternal infection, the placenta can become inflamed, producing cytokines such as IL-6 which is a key biological marker in FIRS often detected in the amniotic fluid and maternal, fetal and umbilical cord serum [54,58,154,155] . Nevertheless, research focusing on the placental migration of cytokines, following maternal infection continues to yield contradictory results as some researchers have observed minimal cytokine migration while others note that the levels that cross the placenta are too negligible to exert any effect.…”

Section: Mia and The Placental Barriermentioning

confidence: 99%

See 1 more Smart Citation

Maternal Immune Activation and Autism Spectrum Disorder: Interleukin-6 Signaling as a Key Mechanistic Pathway

Parker-Athill¹,

Tan²

2010

Neurosignals

122

105

View full text Add to dashboard Cite

An emerging area of research in autism spectrum disorder (ASD) is the role of prenatal exposure to inflammatory mediators during critical developmental periods. Epidemiological data has highlighted this relationship showing significant correlations between prenatal exposure to pathogens, including influenza, and the occurrence of ASD. Although there has not been a definitive molecular mechanism established, researchers have begun to investigate this relationship as animal models of maternal infection have support- ed epidemiological findings. Several groups utilizing these animal models have found that activation of the maternal immune system, termed maternal immune activation (MIA), and more specifically the exposure of the developing fetus to maternal cytokines precipitate the neurological, immunological and behavioral abnormalities observed in the offspring of these animals. These abnormalities have correlated with clinical findings of immune dysregulation, neurological and behavioral abnormalities in some autistic individuals. Additionally, researchers have observed genetic variations in these models in genes which regulate neurological and immunological development, similar to what is observed clinically in ASD. Altogether, the role of MIA and cytokine dysregulation, as a key mediator in the neuropathological, behavioral and possibly genetic irregularities observed clinically in autism are important factors that warrant further investigation.

show abstract

Section: Mia and The Placental Barriermentioning

confidence: 99%

Section: Mia and The Placental Barriermentioning

confidence: 99%

Maternal Immune Activation and Autism Spectrum Disorder: Interleukin-6 Signaling as a Key Mechanistic Pathway

Parker-Athill¹,

Tan²

2010

Neurosignals

122

105

View full text Add to dashboard Cite

show abstract

“…Different authors have used different cut-off values of IL-6 for the diagnosis of EOS. Nishimaki et al 8 have used a cut-off of 54.7 pg/mL. Values as low as 10 pg/mL have been used by Martínez Nadal et al, 17 whereas Smulian et al 18 have used a cutoff of 25 pg/mL.…”

Section: Discussionmentioning

confidence: 99%

“…Previous authors have documented high umbilical cord blood IL-6 concentrations in chorioamnionitis. [6][7][8] In the present study, we compared the statistical validity of cord blood IL-6 concentrations with conventional sepsis screening as an early diagnostic marker of EOS.…”

Section: Introductionmentioning

confidence: 99%

Statistical validity of interleukin-6 as a biomarker for the diagnosis of early-onset neonatal sepsis

Basu

Dewangan

Anupurva

et al. 2012

Microbiol Res (Pavia)

View full text Add to dashboard Cite

Use of empirical antibiotics in neonates with risk factors of early-onset neonatal sepsis (EOS) is a common practice. A laboratory parameter is needed to help in the accurate diagnosis of EOS to avoid unnecessary use of antibiotics. The aim of this prospective observational cohort study was to compare the statistical validity of cord blood interleukin-6 (IL-6) with conventional sepsis screening as an early diagnostic marker for EOS. Eighty-seven neonates with antenatal risk factors for sepsis were followed up for 72 h for the development of EOS. Cord blood was collected for measurement of IL-6 concentrations. Blood culture and conventional sepsis screening (total leukocyte count, absolute neutrophil count, C-reactive protein and micro-erythrocyte sedimentation rate) were sent for analysis soon after delivery. The study group comprised of symptomatic neonates with positive blood culture (n=36). An equal number of gestational-age matched asymptomatic neonates without risk factor of sepsis served as controls. Statistical validity of IL-6 was compared with sepsis screening parameters as the diagnostic marker for EOS. Gram negative organisms were the predominant cause of EOS. The most commonly isolated organism was Acinetobacter baumanii. The sensitivity and specificity of IL-6 with a cut-off value of 40.5 pg/mL and area under curve of 0.959 were 92.3 and 90.48%, respectively. In contrast, the sensitivity and specificity of different parameters of sepsis screening ranged from 37.5-68.75% and 47.95-57.35%, respectively. In conclusion, cord blood IL-6 can be used as a highly sensitive and specific early diagnostic marker of EOS at a cut-off concentration of 40.5 pg/mL.

show abstract

“…This result may be secondary to hypoxic stress that caused subclinical tubular dysfunction [30]. Nishimaki and Shima et al, [31] reported that increased urinary β2MG at birth can indicate fetal inflammatory response and may provide information on the risk of subsequent chronic lung disease.…”

Section: Discussionmentioning

confidence: 99%

Neutrophil-Gelatinase-Associated Lipocalin 2, Krebs Von den Lungen-6, Beta 2 Microglobulin, and Adiponectin: Crosstalk in Early Prediction of Bronchopulmonary Dysplasia in Egyptian Preterm

Soliman¹,

Keshk²,

El-Farargy³

2015

J Mol Biomark Diagn

View full text Add to dashboard Cite

Bronchopulmonary dysplasia (BPD) is a respiratory distress syndrome caused by chronic lung parenchymal injury, occurring primarily in preterm infants. Therefore, research for early biomarkers for BPD is really important. This study was conducted to evaluate levels of Krebs Von den Lungen-6 (KL-6) and adiponectin in cord blood, neutrophil-gelatinase-associated lipocalin 2 (NGAL2) mRNA gene expression in broncho-alveolar lavage and urinary beta 2 microglobulin (β2MG) for early prediction of lung injury or possible involvement of those molecules in BPD pathogenesis and development.Method: this study was carried out from September 2012 to December 2013 with 58 preterm neonates of gestational age ≤32 weeks. KL-6, adiponectin and urinary β2MG levels by immunoassay, NGAL2 mRNA level by real-time PCR were determined.Results: cord blood KL-6, urinary β2MG and broncho-alveolar lavage (BAL) fluid NGAL2 mRNA expression levels were significantly increased, while a non-significant decrease in cord blood adiponectin level in BPD preterm relative to preterm without BPD were observed, with the best sensitivity and specificity were for KL-6 and β2MG relative to preterm without BPD.Conclusion: NGAL2, KL-6, and urinary β2MG may have role in early prediction and development of BPD in preterm neonates that may help in early prevention and treatment for better prognosis and outcome.

show abstract

Comparison of markers for fetal inflammatory response syndrome: Fetal blood interleukin‐6 and neonatal urinary β₂‐microglobulin

Abstract: We suggest that measuring urinary beta(2)-MG in premature infants soon after birth can monitor FIRS and may provide information on the risk of subsequent CLD development that is as clinically important as information derived from umbilical cord blood IL-6.

Cited by 23 publications

References 22 publications

Maternal Immune Activation and Autism Spectrum Disorder: Interleukin-6 Signaling as a Key Mechanistic Pathway

Maternal Immune Activation and Autism Spectrum Disorder: Interleukin-6 Signaling as a Key Mechanistic Pathway

Statistical validity of interleukin-6 as a biomarker for the diagnosis of early-onset neonatal sepsis

Neutrophil-Gelatinase-Associated Lipocalin 2, Krebs Von den Lungen-6, Beta 2 Microglobulin, and Adiponectin: Crosstalk in Early Prediction of Bronchopulmonary Dysplasia in Egyptian Preterm

Contact Info

Product

Resources

About

Comparison of markers for fetal inflammatory response syndrome: Fetal blood interleukin‐6 and neonatal urinary β2‐microglobulin

Abstract: We suggest that measuring urinary beta(2)-MG in premature infants soon after birth can monitor FIRS and may provide information on the risk of subsequent CLD development that is as clinically important as information derived from umbilical cord blood IL-6.

Cited by 23 publications

References 22 publications

Maternal Immune Activation and Autism Spectrum Disorder: Interleukin-6 Signaling as a Key Mechanistic Pathway

Maternal Immune Activation and Autism Spectrum Disorder: Interleukin-6 Signaling as a Key Mechanistic Pathway

Statistical validity of interleukin-6 as a biomarker for the diagnosis of early-onset neonatal sepsis

Neutrophil-Gelatinase-Associated Lipocalin 2, Krebs Von den Lungen-6, Beta 2 Microglobulin, and Adiponectin: Crosstalk in Early Prediction of Bronchopulmonary Dysplasia in Egyptian Preterm

Contact Info

Product

Resources

About

Comparison of markers for fetal inflammatory response syndrome: Fetal blood interleukin‐6 and neonatal urinary β₂‐microglobulin