Comparison of mandibular bone microarchitecture between micro-CT and CBCT images

Abstract

Objectives: To compare microarchitecture parameters of bone samples scanned using micro-CT (mCT) to those obtained by using CBCT. Methods: A bone biopsy trephine bur (3 3 10 mm) was used to remove 20 cylindrical bone samples from 20 dry hemimandibles. Samples were scanned using mCT (mCT 35; SCANCO Medical, Brüttisellen, Switzerland) with a voxel size of 20 mm and CBCT (3D Accuitomo 170; J. Morita, Kyoto, Japan) with a voxel size of 80 mm. All corresponding sample scans were aligned and cropped. Image analysis was carried out using BoneJ, including the following parameters: skeleton analysis, bone surface per total volume (BS/TV), bone volume per total volume (BV/TV), connectivity density, anisotropy, trabecular thickness and spacing, structure model index, plateness and fractal dimension. Pearson and Spearman correlation coefficients (R) were calculated. CBCT values were then calibrated using the slope of the linear fit with the mCT values. The mean error after calibration was calculated and normalized to the standard deviation of the mCT values. Results: R-values ranged between 0.05 (plateness) and 0.83 (BS/TV). Correlation was significant for both Spearman and Pearson's R for 8 out of 16 parameters. After calibration, the smallest normalized error was found for BV/TV (0.48). For other parameters, the error range was 0.58-2.10. Conclusions: Despite the overall correlation, this study demonstrates the uncertainty associated with using bone microarchitecture parameters on CBCT images. Although clinically relevant parameter ranges are not available, the errors found in this study may be too high for some parameters to be considered for clinical application.

Effect of exposure parameters and voxel size on bone structure analysis in CBCT

“…This study is a follow-up to previously published research, 9 in which the correlation between CBCT and micro-CT was evaluated. It involves the same bone samples and largely follows the same approach for image analysis.…”

“…The first exposure setting was determined in the previously mentioned study involving the same samples. 9 The others were selected in order to have a quasi-identical radiation dose, i.e. a CT dose index (CTDI VOL ) of 3.4 mGy.…”

“…Following the study by Panmekiate et al, 9 all scans were thresholded and converted into a binary image using the stack-based "Moments" method developed by Tsai. 16 This is a fully automatic thresholding method (i.e.…”

Curcumin Inhibits Polyethylene-Induced Osteolysis via Repressing NF-κB Signaling Pathway Activation

“…The calvaria specimens were evaluated using micro-CT as described previously [27,28]. The calvaria were carefully excised, cleaned, and fixed immediately in 10% formalin, and then scanned with a µCT 100 scanner (Scanco Medical AG, Brüttisellen, Switzerland).…”

Dento‐alveolar measurements and histomorphometric parameters of maxillary and mandibular first molars, using micro‐CT

“…17,35 Several studies have used micro-CT to assess bone density and microarchitecture of alveolar bone in human maxillae and mandibles on biopsies from cadaver specimens 17,31,[36][37][38] or from patients. 15,30,33 However, in the literature researched, the cadaver-based studies were all performed on less than 30 specimens, 17,31,36 or even on a single specimen only. 37,38 Moreover, both patient and cadaver-based studies analyzed biopsies extracted from edentulous sites only.…”