Comparison of Magnetic Resonance Imaging Findings in Anterior Cruciate Ligament Grafts With and Without Autologous Platelet-Derived Growth Factors

Radice, Fernando; Yáñez, Roberto; Gutiérrez, Vicente Guilarte; Rosales, Julio; Pinedo, Miguel; Coda, Sebastián

doi:10.1016/j.arthro.2009.06.030

Cited by 213 publications

(191 citation statements)

References 30 publications

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“…Se concluyó que la reconstrucción de LCA con el uso de PPR logra completar injertos homogéneos en 179 días, en comparación con 369 días para la reconstrucción de LCA sin PPR. Esto representa una reducción del tiempo de maduración de 48%, lo que sugiere que el PRP aportaría a la velocidad de incorporación del injerto en reparaciones de LCA y, por tanto, se plantea que esto tendría utilidad en un retorno deportivo precoz 22 .…”

Section: Evidencia En Su Uso Clínicounclassified

Uso del plasma rico en plaquetas en cirugía ligamentosa de rodilla

Ximena

et al. 2013

Rev. méd. Chile

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Section: Evidencia En Su Uso Clínicounclassified

Uso del plasma rico en plaquetas en cirugía ligamentosa de rodilla

Ximena

et al. 2013

Rev. méd. Chile

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“…However, a prospective, single blinded MRI study has recently shown a 48% reduction in the time needed to present a complete, homogeneous graft signal with PRP injection versus controls, after surgical ACL reconstruction [35].…”

Section: Prp In Acute Human Ligament Injuriesmentioning

confidence: 99%

How Effective are Injections of Platelet-Rich Plasma (PRP) for the Treatment of Sports Injuries: a Critical Review of the Literature

Allet¹

2012

J Sports Med Doping Stud

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Acute soft-tissue lesions and chronic overuse injuries in the sports medicine field are very frequent and in most cases, difficult to treat. Tissue repair in musculoskeletal lesions is often too slow and sometimes incomplete for a given athlete. The fastest, most complete recovery is of primary importance, and keeping the delay until return-tofield as brief as possible, a priority. Many bioactive proteins and growth factors amongst others influence healing processes. Administration of Platelet Rich Plasma enables the production, from the patient's own blood, of natural, high concentrations of autologous growth factors. Basic research and animal studies are promising, but evidencebased studies examining the treatment of human musculoskeletal lesions by Platelet Rich Plasma are still lacking. Nevertheless, such treatment is increasingly used in sports medicine clinical practice and much is expected of growth factor injections. The aim of this non exhaustive review is to analyze the existing literature published in the fields of sports medicine. The results of this analysis do not permit us to recommend the systematic and generalized use of Platelet Rich Plasma injections in the management of sport injuries. Nevertheless, a few promising results have to be mentioned, but high-quality studies are needed to provide scientific evidence about these injections' effectiveness.

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“…As they undergo this process, platelet activation leads to exocytosis of granular substances, release of newly synthesized mediators, and discharge of membrane-bond trans-cellular signaling molecules (Holmsen, 1989;Broos et al, 2011). Numbers of the various kinds of mechanisms facilitate platelet participation in other physiological or pathological process including inflammation (McNicol et al, 2008), malignancy (Mehta, 1984;Nash et al, 2002), immune response (Elzey et al, 2005;Sowa et al, 2009;Klinger & Jelkmann 2002;Sprague et al, 2008), wound healing (Mazzucco et al, 2010;Ranzato et al, 2009;Rozman & Bolta., 2007;Yamaguchi et al, 2010), and tissue regeneration (Radice et al, 2010;Dugrillon et al, 2002;Hartmann et al, 2010;de Vos et al, 2010;Rodeo et al, 2010).…”

Section: Introductionmentioning

confidence: 99%