Comparison of macular GCIPL and peripapillary RNFL deviation maps for detection of glaucomatous eye with localized RNFL defect

Abstract

ABSTRACT.Purpose: To evaluate the ability of the deviation map of macular ganglion cellinner plexiform layer (GCIPL) thickness compared with that of peripapillary retinal nerve fibre layer (pRNFL) thickness for detection of localized RNFL defects shown on red-free RNFL photography. Methods: This prospective cross-sectional study included 69 eyes of 69 subjects with preperimetric or perimetric glaucoma (mean deviation (MD) >À12dB) and localized RNFL defects along with 79 eyes of 79 normal control subjects. The number of abnormal superpixels on the both macular GCIPL and pRNFL deviation maps by Cirrus OCT corresponding to localized RNFL defects was calculated using a customized Matlab program and presented as severity indices according to each of the probability levels. The areas under the receiver operating characteristic curves (AUROCs) of the severity indices were compared between the two deviation maps. Results: According to three criteria and corresponding probability levels, the AUROCs of the GCIPL and pRNFL deviation maps ranged from 0.910 to 0.931 and 0.934 to 0.950, respectively. However, the differences were not statistically significant (all p > 0.05). Significant correlations were observed between the severity indices of the GCIPL deviation map and those of the pRNFL deviation map, regardless of the criteria (all p < 0.0001). Conclusions: In the detection of glaucomatous eyes with localized RNFL defects, the macular GCIPL thickness deviation map showed a level of diagnostic performance comparable to that of the pRNFL thickness deviation map.

Macular imaging by optical coherence tomography in the diagnosis and management of glaucoma

“…Kim et al 40 reported that the diagnostic performance (presented as area under receiver operating characteristic curve (AUROC)) of the best parameter in macular GCIPL was 0.823 (inferotemporal sector), which result showed no significant difference from those of the best parameters for pRNFL (7 o’clock sector, 0.764) and ONH (rim area, 0.767) in preperimetric glaucoma. Moreover, in preperimetric glaucoma, the macular GCIPL deviation map has demonstrated diagnostic performance comparable to that of the pRNFL deviation map 41. Relevantly too, macular GCA maps have shown good early-glaucoma detection ability (−6 dB <VF mean deviation), the detection rate ranging from 79.4% (thickness map) to 87.8% (deviation map) 12.…”

Optical Coherence Tomographic Analysis of Retina in Retinitis Pigmentosa Patients

“…In glaucoma, it has been confirmed that the ganglion cell IPL deviation map for detecting RNFL defects was equal to the papillary RNFL deviation map [64], and the localized papillary RNFL defects in different spaces corresponded to the ganglion cell IPL defects on the SD-OCT deviation map in glaucoma [65]. However, no consistent verdict has been reached with regard to the ganglion cell changes in RP patients, and whether RNFL defects are consistent with the ganglion cell IPL defects is unknown.…”

Structural analysis of retinal photoreceptor ellipsoid zone and postreceptor retinal layer associated with visual acuity in patients with retinitis pigmentosa by ganglion cell analysis combined with OCT imaging

“…It has been confirmed to be valuable for diagnosing glaucoma obtained by ganglion cell analysis (GCA) incorporate into the new optical coherence tomography (OCT) device, which reflects localized RNFL defects better than papillary RNFL in advanced glaucoma. [18,19] However, there is no article to study about GCIPL changes in RP patients by GCA, and the thickness in the previous studies was measured from 2 or 4 points by manual [20,21] ; therefore, it is necessary to reconfirm the condition of ganglion cells in RP. Visual function in RP cases was proved to be related with morphological changes of the photoreceptors in the macular area.…”