Comparison of macular function and visual fields after membrane blue or infracyanine green staining in vitreoretinal surgery

Schmid-Kubista, Katharina E.; Lamar, P.; Schenk, Alexandra; Stolba, U.; Binder, Susanne

doi:10.1007/s00417-009-1213-4

Cited by 17 publications

(7 citation statements)

References 43 publications

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“…In particular, ICG is supposed to bring about a dose- and illumination-dependent toxicity [10,11] to the retinal ganglion cells and the retinal pigment epithelium [12,13]. However, regarding the functional outcome of ILM peeling with ICG or BBG after a period of 6 months, no significant differences were found [14]. Therefore, the intention of this study was to examine ultrastructural features on the ILM by ICG or BBG to gain a picture of retinal alterations secondary to membrane peeling.…”

Section: Introductionmentioning

confidence: 99%

Ultrastructure of the Membrana Limitans Interna after Dye-Assisted Membrane Peeling

Brockmann

Steger²,

Westermann³

et al. 2011

Ophthalmologica

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The purpose of this study was to investigate the ultrastructure of the membrana limitans interna (internal limiting membrane, ILM) and to evaluate alterations to the retinal cell layers after membrane peeling with vital dyes. Twenty-five patients (25 eyes) who underwent macular hole surgery were included, whereby 12 indocyanine green (ICG)- and 13 brilliant blue G (BBG)-stained ILM were analyzed using light, transmission electron and scanning electron microscopy. Retinal cell fragments on the ILM were identified in both groups using immunohistochemistry. Comparing ICG- and BBG-stained membranes, larger cellular fragments were observed at a higher frequency in the BBG group. Thereby, the findings indicate that ICG permits an enhanced separation of the ILM from the underlying retina with less mechanical destruction. A possible explanation might be seen in the known photosensitivity of ICG, which induces a stiffening and shrinkage of the ILM but also generates retinal toxic metabolites.

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Section: Introductionmentioning

confidence: 99%

Ultrastructure of the Membrana Limitans Interna after Dye-Assisted Membrane Peeling

Brockmann

Steger²,

Westermann³

et al. 2011

Ophthalmologica

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“…While BBG selectively stains the ILM, staining intensity has been reported to be significantly inferior to that of ICG 9 14 15. A number of methods to promote intraoperative BBG sedimentation, such as dye cooling16 and a solution in 4% polyethylene glycol,4 and 5% glucose17 and visco-BBG18 and heavy-water BBG (BBG-D 2 O) have been suggested. However, the only objective measurement of BBG's staining characteristics with CIELAB scores was evaluated for BBG-D 2 O; objective chromaticity scores suggested that ILM staining is not significantly improved with the new formula 9…”

Section: Discussionmentioning

confidence: 99%

Brilliant blue G assisted macular surgery: the effect of air infusion on contrast recognisability in internal limiting membrane peeling

et al. 2014

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“…13,30,32,33 Trypan blue is generally recommended for the removal of epiretinal tissue rather than for ILM peeling itself, 34 although several clinical studies suggest that TB may be more useful for ILM removal than customarily conceived. [31][32][33][35][36][37] Retinal toxicity has been occasionally reported from in vitro experiments 38 and in vivo studies, 39,40 while other authors found no indications for in vivo toxicity. 16,37,[41][42][43] The presence of ERM overlying the ILM requires a sequential approach.…”

Section: Discussionmentioning

confidence: 99%

Quantification of Contrast Recognizability in Sequential Epiretinal Membrane Removal and Internal Limiting Membrane Peeling in Trypan Blue–assisted Macular Surgery

Henrich

Priglinger

Haritoglou

et al. 2013

Retina

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Purpose: To evaluate the selectivity and strength of intraoperative trypan blue staining during removal of epiretinal membranes (ERMs) and the internal limiting membrane.Methods: Based on intraoperative videos, 51 consecutive chromovitrectomies in 51 patients with macular holes, macular pucker, vitreomacular traction syndromes, or persistent macular edema were retrospectively studied. Fifteen subjects underwent trypan blue, 14 indocyanine green, and 22 brilliant blue G chromovitrectomy. The main outcome measure was the color contrast between stained internal limiting membrane or ERM and the underlying unstained tissue by means of objective, quantitative, semiautomated chromaticity difference measurements.Results: Trypan blue stains both ERM and the internal limiting membrane (average chromaticity scores 8.51 and 7.09, respectively; P = 0.48). Internal limiting membrane chromaticity scores were similar for trypan blue (7.09) and brilliant blue G (6.81; P = 0.71) but clearly higher for indocyanine green (15.81; P = 2.45 · 10 −5 ).Conclusion: Under the premises of our study, trypan blue stains both ERM and the internal limiting membrane. Trypan blue's staining capacity of the internal limiting membrane is similar to that of brilliant blue G but significantly inferior compared with indocyanine green. Trypan blue, thus, represents a useful vital dye for chromovitrectomy, particularly in the presence of ERM, where it allows a sequential approach.

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Comparison of macular function and visual fields after membrane blue or infracyanine green staining in vitreoretinal surgery

Cited by 17 publications

References 43 publications

Ultrastructure of the Membrana Limitans Interna after Dye-Assisted Membrane Peeling

Ultrastructure of the Membrana Limitans Interna after Dye-Assisted Membrane Peeling

Brilliant blue G assisted macular surgery: the effect of air infusion on contrast recognisability in internal limiting membrane peeling

Quantification of Contrast Recognizability in Sequential Epiretinal Membrane Removal and Internal Limiting Membrane Peeling in Trypan Blue–assisted Macular Surgery

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