Comparison of Lysergic Acid Derivatives and Antihistamines as Inhibitors of the Edema Provoked in the Rat’s Paw by Serotonin

Effect of Sympathomimetic and Allied Amines on Temperature and Oxygen Consumption in Chickens

“…In the second, dexamphetamine was injected after pretreating 2 adult fowls with mebanazine (100 p-mole/kg 100 min previously). In one, dexamphetamine (10 a-mole/kg) increased core and surface temperatures 20 C. The temperatures rose immediately after injection from 40.50 C to a peak 45 min later of 42.50 C, which was sustained for 30 min when temperature was restored to pre-injection values by methysergide, 0.1 t-mole/kg) a specific tryptamine antagonist (Doepfner & Cerletti, 1958). In the other fowl, dexamphetamine (5 and 10 n-mole/kg) had no effect on temperature but a rise of 2.10 C followed a dose of 20 tt-mole/kg.…”

Tryptamines and Spinal Cord Reflexes in Cats

“…Antagonist at tryptamine receptors. Methysergide, a potent antagonist at tryptamine receptors (Doepfner & Cerletti, 1958) prevented the effects of tryptamine on the spinal reflex (Fig. 6).…”

Indoleamine Antagonists: Relative Potencies as Inhibitors of Tryptamine‐ and 5‐hydroxytryptophan‐evoked Responses

“…(CNS) are the head twitch response provoked by administration of 5-hydroxytryptophan (5-HTP) and the clonus of the forepaws induced by injection of tryptamine. Even for well-known indoleamine antagonists such as cyproheptadine (Stone, Wenger, Ludden, Stavorski & Ross, 1961), cinanserin (Rubin, Piala, Burke & Craver, 1964), methergoline (Ferrini & Glasser, 1965) and methysergide (Doepfner & Cerletti, 1958) 5-hydroxytryptophan-elicited head twitch The head-twitch response was assessed on a quantal basis as previously described in mice by Corne, Pickering & Warner (1963). The antagonists were administered 30 min prior to 5-HTP (270 mg/kg) and the number of animals exhibiting at least one head twitch was determined 1 h later.…”