Comparison of long-term results of trabeculectomy to treat pseudoexfoliative glaucoma and primary open angle glaucoma

Gürlü, Vuslat; Güçlü, Hande; Özal, Altan; Benian, Ömer; Alimgil, Levent

doi:10.18240/ijo.2018.01.12

Cited by 5 publications

(3 citation statements)

References 22 publications

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“…Thus, it may be assumed that eyes with PXG are more prone to fibrotic alterations of suprachoroidal glaucoma implants. However, Gürlü et al [ 14 ] found no difference in the success of trabeculectomy between PXG and POAG, as well as no difference in efficacy of XEN gel stent implantation between PXG and PDG [ 15 – 17 ].…”

Section: Discussionmentioning

confidence: 99%

Ultrastructural analysis of explanted CyPass microstents and correlation with clinical findings

Hübner

Schlötzer‐Schrehardt

Weller

et al. 2022

Graefes Arch Clin Exp Ophthalmol

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Purpose The purpose of this study was to obtain insight into cellular processes after CyPass microstent implantation into the supraciliary space. With this knowledge, we expected to find some reason for surgical failure. Methods Nine CyPass microstents of 8 patients with primary open-angle glaucoma (n = 1), pseudoexfoliation glaucoma (n = 5), uveitic glaucoma (n = 1), and posttraumatic open-angle glaucoma (n = 1) were explanted due to recurrence of IOP elevation, corneal decompensation, or persistent hypotony. The explants were processed for light and transmission electron microscopy. Results Fibrotic material, consisting of collagen fibrils, microfibrils, pseudoexfoliation fibrils produced by activated fibroblasts, was detected in the stent lumen of 4/5 pseudoexfoliation glaucoma patients and also in posttraumatic open-angle glaucoma. Fibrotic material was also present on the outer surface and within fenestrations of the majority of stents. Complete absence of fibrotic reaction was noticed in 3 of 9 microstents. Conclusion Although MIGS is known to be less invasive than conventional surgery, implants placed in the suprachoroidal space may be adversely affected by a fibrotic tissue reaction resulting in implant failure. Understanding mechanisms and risk factors leading to fibrotic scarring following antiglaucomatous surgery may help to develop novel strategies that improve surgical outcome.

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Section: Discussionmentioning

confidence: 99%

Ultrastructural analysis of explanted CyPass microstents and correlation with clinical findings

Hübner

Schlötzer‐Schrehardt

Weller

et al. 2022

Graefes Arch Clin Exp Ophthalmol

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“…Ehrnrooth et al [78] compared 55 POAG eyes with 83 XFG eyes and found a significantly higher overall success rate for patients with POAG than XFG and reported that a higher preoperative IOP>30 mm Hg in the early postoperative period having an adverse effect on the surgical success of TRAB in XFG. Another study by Gurlu et al [79] found no significant difference in the long-term success of TRAB between the two groups whose clinical characteristics are otherwise similar.…”

Section: Trab In Pseudoexfolaition Glaucomamentioning

confidence: 91%

“…Pseduoexfoliative glaucoma (XFG) is known to be more aggressive than other types of glaucoma with a high rate of intraoperative complications like vitreous loss, zonular damage, clinically significant choroidal detachment, and choroidal hemorrhage [78][79][80][81]. Popovic and Sjostrand [80] compared the efficacy of TRAB in XFG eyes and POAG eyes and reported comparable results in both with a marginally better outcome in XFG eyes.…”

Section: Trab In Pseudoexfolaition Glaucomamentioning

confidence: 99%

Trabeculectomy: Does It Have a Future?

Rao¹,

Cruz²

2022

Cureus

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The trabeculectomy (TRAB) procedure has undergone various modifications to increase the long-term surgical success and safety profiles. The main issues with TRAB include short and long-term complications, that are more common with the concomitant use of anti-fibrotic agents. While many surgeons have predicted the demise of trabeculectomy amidst newer non-penetrating glaucoma surgeries, it is still the gold standard procedure for patients with an advanced or rapidly progressing disease and for those patients who need very low intraocular pressures. This review article is unique in summarizing the evolution of trabeculectomy and its efficacy compared to neoteric shunt procedures while trying to predict if trabeculectomy has a future in the modern surgical world. We have compared the outcomes and complications of trabeculectomy to all the surgical procedures available to date and have tried to evolve an algorithm to help surgeons to decide on their preferred technique.

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Comparison of long-term results of trabeculectomy and phacotrabeculectomy in patients with pseudoexfoliation glaucoma and primary open-angle glaucoma: a single-center study

Tuğan

Yüksel

Kesim³

et al. 2022

Int Ophthalmol

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Comparison of long-term results of trabeculectomy to treat pseudoexfoliative glaucoma and primary open angle glaucoma

Abstract: There is no difference in the long-term success of trabeculectomy between PEG and POAG patients whose clinical characteristics are otherwise the same.

Cited by 5 publications

References 22 publications

Ultrastructural analysis of explanted CyPass microstents and correlation with clinical findings

Ultrastructural analysis of explanted CyPass microstents and correlation with clinical findings

Trabeculectomy: Does It Have a Future?

Comparison of long-term results of trabeculectomy and phacotrabeculectomy in patients with pseudoexfoliation glaucoma and primary open-angle glaucoma: a single-center study

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