Comparison of long-term cosmetic outcomes for different treatments of superficial basal cell carcinoma

Jansen, Maud H.E.; Koekelkoren, Fabiënne H. J.; Nelemans, Patty J.; Arits, A.H.M.M.; Roozeboom, Marieke H.; Kelleners‐Smeets, Nicole W.J.; Mosterd, Klara

doi:10.1016/j.jaad.2018.04.053

Cited by 17 publications

(19 citation statements)

References 5 publications

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“…We found a good/excellent cosmetic outcome in 71.6% of all the lesions at three months. We did not achieve the results of Jansen et al 8 (the same trial as by Arits et al), who reported a good/excellent cosmetic outcome in MAL-PDT for 89.5% of patients at five years. However, the cosmetic outcome tends to improve over time.…”

Section: Discussioncontrasting

confidence: 69%

“…Non‐surgical options provide a cost‐effective alternative to surgery in the treatment of non‐aggressive BCCs, 40 and patients with multiple lesions or facial lesions are willing to risk the recurrence rate for a better cosmetic outcome 41 . The advantages of PDT include the cosmetic outcome, 8 the shorter application and downtimes, and the mode of delivery, 9 but the major disadvantage is the lower efficacy compared to imiquimod 6 . However, the topical creams demand good patient compliance and correct patient selections, as the creams are applied by the patient at home for a number of weeks.…”

Section: Discussionmentioning

confidence: 99%

“…[6][7] The advantages of PDT include a superior cosmetic outcome and short application and down times. 8,9 Photodynamic therapy uses a combination of light, a photosensitizing agent (an exogenous source for photoactive protoporphyrin IX, PpIX) and oxygen to generate a radical oxygen species that cause cell apoptosis and necrosis. 10,11 Of these factors, PpIX production in particular seems to be related to cell death.…”

Section: Introductionmentioning

confidence: 99%

“…photodynamic therapy (PDT), imiquimod or 5‐fluorouracil (5‐FU), where imiquimod has superior efficacy 6‐7 . The advantages of PDT include a superior cosmetic outcome and short application and down times 8,9 …”

Section: Introductionmentioning

confidence: 99%

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Hexyl aminolevulinate, 5‐aminolevulinic acid nanoemulsion and methyl aminolevulinate in photodynamic therapy of non‐aggressive basal cell carcinomas: A non‐sponsored, randomized, prospective and double‐blinded trial

Salmivuori

Grönroos

Tani

et al. 2020

Acad Dermatol Venereol

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Background In the photodynamic therapy (PDT) of non-aggressive basal cell carcinomas (BCCs), 5-aminolevulinic acid nanoemulsion (BF-200ALA) has shown non-inferior efficacy when compared with methyl aminolevulinate (MAL), a widely used photosensitizer. Hexyl aminolevulinate (HAL) is an interesting alternative photosensitizer. To our knowledge, this is the first study using HAL-PDT in the treatment of BCCs. Objectives To compare the histological clearance, tolerability (pain and post-treatment reaction) and cosmetic outcome of MAL, BF-200 ALA and low-concentration HAL in the PDT of non-aggressive BCCs. Methods Ninety-eight histologically verified non-aggressive BCCs met the inclusion criteria, and 54 patients with 95 lesions completed the study. The lesions were randomized to receive LED-PDT in two repeated treatments with MAL, BF-200 ALA or HAL. Efficacy was assessed both clinically and confirmed histologically at three months by blinded observers. Furthermore, cosmetic outcome, pain, post-treatment reactions fluorescence and photobleaching were evaluated. Results According to intention-to-treat analyses, the histologically confirmed lesion clearance was 93.8% (95% confidence interval [CI] = 79.9-98.3) for MAL, 90.9% (95% CI = 76.4-96.9) for BF-200 ALA and 87.9% (95% CI = 72.7-95.2) for HAL, with no differences between the arms (P = 0.84). There were no differences between the arms as regards pain, post-treatment reactions or cosmetic outcome. Conclusions Photodynamic therapy with low-concentration HAL and BF-200 ALA has a similar efficacy, tolerability and cosmetic outcome compared to MAL. HAL is an interesting new option in dermatological PDT, since good efficacy is achieved with a low concentration.

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Section: Discussioncontrasting

confidence: 69%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Hexyl aminolevulinate, 5‐aminolevulinic acid nanoemulsion and methyl aminolevulinate in photodynamic therapy of non‐aggressive basal cell carcinomas: A non‐sponsored, randomized, prospective and double‐blinded trial

Salmivuori

Grönroos

Tani

et al. 2020

Acad Dermatol Venereol

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show abstract

“…For superficial BCC, cosmetic outcome is becoming an important criterium. Methyl aminolevulinate photodynamic therapy, imiquimod, or 5-fluorouracil might be an alternativetreatment choice for these patients 6.…”

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confidence: 99%