Comparison of locally advanced cervical cancer treatment guidelines in Asia

Abstract

minute interval) during surgery, were collected. Using the preoperative noninvasive and intraoperative invasive systolic blood pressure values, we calculated the average real variability (ARV), known as a reliable representation of time series blood pressure variability. Associations between the ARV index and survival outcomes were investigated. Results: In total, 441 patients were included. Using the integer close to the median as a cut-off value for the ARV, we found that the high-ARV group (≥8; n=220) showed worse progression-free survival (PFS) than the low-ARV group (<8; n=221) (median=82.8% vs. 89.6%; p=0.020). In multivariate analysis adjusting for confounders, ARV ≥8 was identified as an independent poor prognostic factor for PFS (adjusted hazard ratio [HR]=1.887; 95% confidence interval [CI]=1.158-3.076; p=0.011). In the subgroup of open RH (n=238), ARV ≥8 was associated with significantly worse PFS (adjusted HR=2.402; 95% CI=1.119-5.155; p=0.024). In contrast, in the subgroup of MIS RH (n=238), PFS did not differ by the ARV index. Conclusion:The ARV index, indicating intraoperative hemodynamic instability, might be a novel prognostic biomarker for disease recurrence in early cervical cancer patients who receive primary open RH, not MIS RH. Oral (OC3) Cervical Cancer