Comparison of local anesthetic effect of lidocaine by jet injection vs needle infiltration in lumbar puncture

Hajimaghsoudi, Majid; Vahidi, Elnaz; Momeni, Mehdi; Arabinejhad, Abbas; Saeedi, Morteza

doi:10.1016/j.ajem.2016.03.030

Cited by 8 publications

(5 citation statements)

References 9 publications

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“…Two studies have observed the duration of anaesthesia to be reduced with jet injection [12], [16], while one of these also found the onset time to be shorter [16]. These contrast with findings from transdermal delivery studies that observed an increased onset time for jet injected anaesthetic relative to standard needle-based delivery [31], [32]. To evaluate the anaesthetic effect resulting from delivery with our device, and any associated discomfort, an in vivo clinical trial is required.…”

Section: Discussionmentioning

confidence: 78%

Controllable Jet Injection of Dental Local Anaesthetic

McKeage

Loch

Zwirner

et al. 2021

IEEE J. Transl. Eng. Health Med.

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Fear of dental procedures is a common barrier to effective dental care. A promising technique to overcome dental anxiety is needle-free jet injection, which involves delivering local anaesthetic as a high-speed jet capable of penetrating the oral mucosa without a needle. Previous efforts have used loud, uncontrolled injectors designed for transdermal delivery that have failed to achieve significant uptake in dental practice. Methods: In this work, we present and validate a controllable jet injection device driven by a silent electric motor for the delivery of dental local anaesthetic. The injector includes a novel tubular attachment at its distal end, which allows the delivery to be performed comfortably throughout the mouth. The expected pressure loss resulting from the use of this attachment is analysed. This analysis predicted that a 75 mm long tubular attachment of 0.53 mm radius would result in negligible pressure loss. To validate delivery in human tissue, the injection system was used to perform 18 injections into the mouths of two Thiel-embalmed human cadavers. These injections were visualised using cone-beam computed tomography (CBCT). Results: Benchtop testing of the prototype injector verified the expected pressure loss along the attachment. The CBCT scans demonstrated that the fluid was successfully delivered to the desired locations, adjacent to the root apex of the teeth, at every injection site. Conclusion: These outcomes validate the performance of this novel needle-free injector, demonstrating its potential as a tool to reduce dental anxiety.

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Section: Discussionmentioning

confidence: 78%

Controllable Jet Injection of Dental Local Anaesthetic

McKeage

Loch

Zwirner

et al. 2021

IEEE J. Transl. Eng. Health Med.

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show abstract

“…Common rationale for providers to forgo pain management included time for TAs to be effective, pain associated with injectable lidocaine, and loss of anatomic landmarks with injectable lidocaine. Hajimaghsoudi et al . showed lower pain scores in adults during J‐Tip lidocaine application and during the LP compared to standard local infiltration.…”

Section: Discussionmentioning

confidence: 99%

“…One study compared the J‐Tip with lidocaine to J‐Tip with saline solution during infant LPs and found superior pain control and reduced time of crying in the lidocaine group . A recent study of LPs in adults demonstrated superior pain control using the J‐Tip compared to local needle infiltration of lidocaine …”

mentioning

confidence: 99%

A Randomized Double Blind Trial of Needle‐free Injected Lidocaine Versus Topical Anesthesia for Infant Lumbar Puncture

Caltagirone

Raghavan

Adelgais

et al. 2017

Academic Emergency Medicine

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“…The injection was administered into a collecting cup, and injection mass was measured using precision balance for injected fluid. Finally, the injection mass measurements for each dose limiter were converted into injection volume by dividing the injection mass with the density of working fluid [85].…”

Section: Injection Pressure and Volume Measurementmentioning

confidence: 99%

“…Auto-reloading jet injection systems (ARJIs) can perform 1000 injections per hour and are used in the mass vaccination of livestock. They can be used to deliver a variety of drugs like insulin, lidocaine, DNA vaccines, and anti-tumor drugs that interfere with RNA [55,[82][83][84][85][86]. Typical jet injectors pressurize the liquid at around 20 MPa, and typically have a single outlet in the form of a nozzle or orifice with diameters ranging between 30 and 300 µm.…”

Section: Introductionmentioning

confidence: 99%

A Needle-Free Jet Injection System for Controlled Release and Repeated Biopharmaceutical Delivery

Trimzi

Ham

2021

Pharmaceutics

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Swift vaccination is necessary as a response to disease outbreaks and pandemics; otherwise, the species under attack is at risk of a high fatality rate or even mass extinction. Statistics suggest that at least 16 billion injections are administered worldwide every year. Such a high rate of needle/syringe injection administration worldwide is alarming due to the risk of needle-stick injuries, disease spread due to cross-contamination and the reuse of needles, and the misuse of needles. In addition, there are production, handling, and disposal costs. Needle phobia is an additional issue faced by many recipients of injections with needles. In addition to a detailed literature review highlighting the need for needle-free injection systems, a compressed air-driven needle-free jet injection system with a hydro-pneumatic mechanism was designed and developed by employing an axiomatic design approach. The proposed injection system has higher flexibility, uninterrupted force generation, and provides the possibility of delivering repeated injections at different tissue depths from the dermis to the muscle (depending on the drug delivery requirements) by controlling the inlet compressed air pressure. The designed needle-free jet injector consists of two primary circuits: the pneumatic and the hydraulic circuit. The pneumatic circuit is responsible for driving, pressurizing, and repeatability. The hydraulic circuit precisely injects and contains the liquid jet, allowing us to control the volume of the liquid jet at elevated pressure by offering flexibility in the dose volume per injection. Finally, in this paper we report on the successful design and working model of an air-driven needle-free jet injector for 0.2–0.5 mL drug delivery by ex vivo experimental validation.

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Comparison of local anesthetic effect of lidocaine by jet injection vs needle infiltration in lumbar puncture

Cited by 8 publications

References 9 publications

Controllable Jet Injection of Dental Local Anaesthetic

Controllable Jet Injection of Dental Local Anaesthetic

A Randomized Double Blind Trial of Needle‐free Injected Lidocaine Versus Topical Anesthesia for Infant Lumbar Puncture

A Needle-Free Jet Injection System for Controlled Release and Repeated Biopharmaceutical Delivery

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