Comparison of liver histology with ultrasonography in assessing diffuse parenchymal liver disease

Joseph, A.E.A.; Saverymuttu, S. H.; Al-Sam, Salam; Cook, Martin; Maxwell, J. D.

doi:10.1016/s0009-9260(05)80350-2

Cited by 459 publications

(338 citation statements)

References 10 publications

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“…Previous studies in which ultrasound findings were compared to histologic results showed that the overall sensitivity and specificity of ultrasound examination for diagnosis of fatty liver were approximately 80-95% and 90-95%, respectively. [46][47][48][49][50][51] Moreover, due to sampling errors, liver biopsies are reported as normal in subjects with focal fatty infiltration of the liver (approximately 5-10%). 52 Besides, due to ethical reason, liver biopsy cannot be performed in these relatively healthy individuals without overt liver abnormality.…”

Section: Discussionmentioning

confidence: 99%

Mesenteric fat thickness as an independent determinant of fatty liver

Liu

Chan

et al. 2006

Int J Obes

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Objective: Mesenteric fat is drained by the portal circulation and has been suggested to be a key component in obesity-related health risk, notably the metabolic syndrome. There are increasing epidemiological and experimental data showing that fatty liver is another component of this multifaceted syndrome. Given their intimate anatomical and physiological relationships, we hypothesized that mesenteric fat thickness may be independently associated with the risk of fatty liver. To test this hypothesis, we examined the predictive role of various fat deposits including mesenteric fat thickness, and various metabolic variables on the risk of fatty liver. Subjects and methods: A total of 291 Chinese subjects (134 men and 157 women with a mean BMI of 23.7 kg/m 2 , range: 16.5-33.4 kg/m 2 ) underwent ultrasound examination for measurement of mesenteric, subcutaneous and preperitoneal fat thickness, and for diagnosis of fatty liver. Body mass index, waist circumference, and waist-hip ratio were recorded. Blood pressure was measured. Fasting plasma glucose, insulin resistance, high-density lipoprotein cholesterol (HDL-C), triglycerides, low-density lipoprotein cholesterol (LDL-C), liver enzymes were determined by common methods. Results: The subjects with fatty liver had greater abdominal fat thickness and higher anthropometric indexes than those without fatty liver. The subjects with fatty liver also showed higher blood pressure, worse lipid and glycaemic profile compared with those without fatty liver. Using multiple logistic regression analysis, mesenteric fat thickness was a risk factor of fatty liver, independent of body mass index, age, sex, insulin resistance, fasting plasma glucose, lipid and blood pressure. The odds ratio was 1.5 (95% confidence interval: 1.27-1.77) for every 1 mm increase in the mesenteric fat thickness. Measurement of preperitoneal and subcutaneous fat deposits did not show significant associations with fatty liver. Conclusion: Mesenteric fat thickness measured on ultrasound is an independent determinant of fatty liver.

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Section: Discussionmentioning

confidence: 99%

Mesenteric fat thickness as an independent determinant of fatty liver

Liu

Chan

et al. 2006

Int J Obes

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“…12,13 Repeat measurements in a random subgroup of 20 participants gave intraobserver and interobserver coefficients of variation of <5%.…”

Section: Non-alcoholic Fatty Liver Diseasementioning

confidence: 99%

A Simple Indian Diabetes Risk Score Could Help Identify Nondiabetic Individuals at High Risk of Non-Alcoholic Fatty Liver Disease (CURES-117)

Anbalagan

Venkataraman

Vamsi

et al. 2012

J Diabetes Sci Technol

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Abbreviations: (ALT) alanine aminotransferase, (AST) aspartate aminotransferase, (BMI) body mass index, (CURES) Chennai Urban Rural Epidemiology Study, (HbA1c) glycated hemoglobin, (HDL) high-density lipoprotein, (HOMA-IR) homeostasis assessment model for insulin resistance, (IDRS) Indian diabetes risk score, (LDL) low-density lipoprotein, (NAFLD) non-alcoholic fatty liver disease, (NASH) non-alcoholic steatohepatitis, (NCD) noncommunicable disease, (OR) odds ratio

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“…10 out of 11 patients with echogenic liver, who went on to have a liver biopsy, had NAFLD. Insensitivity of the USS occurs when steatosis affects less than one-third of the liver volume [6,34,35]. This probably explained the normal USS appearances of five patients with biopsy-proven NAFLD and highlights the usefulness of a liver biopsy.…”

Section: Discussionmentioning

confidence: 88%

Nonalcoholic fatty liver disease in a district general hospital: clinical presentation and risk factors

Syn

Bateman

2008

Hepatol Int

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Introduction Nonalcoholic fatty liver disease (NAFLD) affects one-fifth of the adult population and is currently the commonest liver problem in the western world. The prevalence of NAFLD is likely to rise over the coming decades in parallel to the obesity and diabetes epidemics. A retrospective study was undertaken in a UK. district general hospital (DGH) to determine the clinical and laboratory features of patients with NAFLD. Methods and findings A total of 48 patients with NAFLD were identified. Most (54%) were asymptomatic on presentation and 90% had an echogenic liver on ultrasonography (USS). Liver tests were elevated in the majority, but did not distinguish between simple steatosis and steatohepatitis. Having features of the metabolic syndrome and a low platelet count (P = 0.028) may help identify patients with advanced hepatic fibrosis. Conclusions NAFLD is common in the DGH and should be considered in all patients with metabolic risk factors. A liver biopsy should be considered in those with low platelets, type II diabetes mellitus, and the metabolic syndrome.

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Comparison of liver histology with ultrasonography in assessing diffuse parenchymal liver disease

Cited by 459 publications

References 10 publications

Mesenteric fat thickness as an independent determinant of fatty liver

Mesenteric fat thickness as an independent determinant of fatty liver

A Simple Indian Diabetes Risk Score Could Help Identify Nondiabetic Individuals at High Risk of Non-Alcoholic Fatty Liver Disease (CURES-117)

Nonalcoholic fatty liver disease in a district general hospital: clinical presentation and risk factors

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