Comparison of liver enzymes and sonological grading in nonalcoholic fatty liver

Jwarchan, Bishnu; Lalchan, Subita; Dhakal, Anil; Acharya, Ramesh Raj

doi:10.3126/ajms.v11i2.27203

Cited by 6 publications

(6 citation statements)

References 9 publications

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“…In our study, a significant association was observed between patients with no related symptoms and advanced grading of NAFLD (p=0.02). Consistently, Armstrong et al 39 study in UK revealed that high proportion of patients with advanced grading of NAFLD were asymptomatic.…”

Section: Discussionsupporting

confidence: 53%

Correlation between nonalcoholic fatty liver disease by ultrasound with hepatic veins spectral doppler and aminotransferases

Abdullah

Ahmed

2022

ijhs

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Background: Nonalcoholic fatty liver disease is a common cause of chronic liver diseases in developed countries. Ultrasound imaging is widely used in evaluation of liver disease. The alanine transaminase and aspartate transaminase are common laboratory investigations in diagnosing liver diseases. Methodology: A cross sectional study was conducted at the Rizgary and Hawler teaching hospitals from March to 2021 to April 2022 on sample of one hundred and fifty adult patients with non-alcoholic liver fatty disease. After excluding other cause of increasing liver echogenicity, patients were diagnosed as having NAFLD if they have elevated liver enzymes with a report of fatty liver in sonographic evaluation. Results: Mean ALT of patients was (88.3 U/L); 3% of them had normal ALT, 34% of them had ALT of 57-80 U/L, 45.3% of them had ALT of 81-100 U/L and 18.7% of patients had ALT of more than 100 U/L. while and mean AST of NAFLD patients was (28.5 U/L); 10% of them had high AST. The result shows a highly significant association between increasing of ALT level and advanced grading of NAFLD.

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Section: Discussionsupporting

confidence: 53%

Correlation between nonalcoholic fatty liver disease by ultrasound with hepatic veins spectral doppler and aminotransferases

Abdullah

Ahmed

2022

ijhs

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“…Similar findings were found in study done in Manipal. 11 This study revealed that SGPT and SGOT were the only liver enzyme showing statistically significant difference in between NAFLD (p = 0.02, p = 0.03) suggesting the level of enzyme increased significantly with higher grades of NAFL. Similar association was seen in the study done by Saxena in India.…”

Section: Discussionmentioning

confidence: 60%

“…The convenience sampling method was used and the sample size was calculated using the formula, Sample size (N) = Z 2 pq/e 2 ; Where Z = 1.96 at 95% confidence level; p = 0.3412 (34.12%) 11 ; q = 1-p = 0.6588; e = 0.09 (9% margin of error). The total sample size calculated was 106.60 ≈ 107.…”

Section: Methodsmentioning

confidence: 99%

Sonological grading of non-alcoholic fatty liver and comparison with liver enzymes

Chaudhary,

Kafle,

Karki

et al. 2023

J. Kathmandu Med. Coll.

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Background: Non-alcoholic fatty liver disease (NAFLD) is becoming more well acknowledged as a significant contributor to liver-related morbidity and mortality. Objectives: To assess the sonological grading of non-alcoholic fatty liver disease and comparison with liver enzymes. Methods: An analytical cross-sectional study was conducted from 2022 August to 2023 January among the patients referred to radiology unit for liver sonography with diagnosis of non-alcoholic liver disease. Ethical approval was obtained from the institutional review committee of Kathmandu Medical College (Ref. 12082022/06). A convenience sampling method was used. The sample size calculated was 107. Descriptive statistics (frequencies, means, and standard deviations) was used to describe the variables of interest. One-way analysis of variance was applied for comparison of serum liver enzymes in between various grades of NAFLD at 5% significance level. Results: Mean age of the patients was 37.9 ± 17.8 years, with 60% females. Most patients had grade I NAFLD (82, 76.6%), whereas 23 (21.5%) were of grade II. Levels of liver enzyme: Serum glutamic pyruvic transaminase (SGPT) with p-value 0.02 and serum glutamic oxaloacetic transaminase (SGOT) with p-value 0.03 were associated with fatty liver grade. Conclusion: Ultrasound-based grading of the severity of NAFLD was associated with abnormalities in the liver enzyme profile of patients. The SGPT and SGOT levels correlated with increasing severity of NAFLD based on ultrasound.

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“…A study with 85 subjects concluded that women (65.88%) had a higher incidence of NAFLD than men (34.12%). Only ALT revealed a significant variation across grade 1 and grade 2 NAFLD (p=0.027) 19 . However, the current study had no significant variation acorss the grades, but significant difference was seen between the controls and the NAFLD grades.…”

Section: Discussionmentioning

confidence: 97%

Significance of serum ferritin and De Ritis ratio in non-alcoholic fatty liver disease as diagnostic markers

Anoshia Javed,

Dr. Khadija Mehboob,

Amir Rashid

et al. 2024

J Pak Med Assoc

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Objective: To ascertain the significance of serum ferritin and De Ritis ratio as diagnostic markers in patients of non-alcoholic fatty liver disease with and without type 2 diabetes mellitus. Methods: The comparative cross-sectional study was conducted from February to October 2022 at the Radiology Department of Combined Military Hospital, Rawalpindi, Pakistan, and comprised individuals aged 30-65 who were divided into 3 groups. Healthy controls formed group I, non-alcoholic fatty liver disease patients without type 2 diabetes mellitus formed group II and non-alcoholic fatty liver disease patients with type 2 diabetes mellitus were in group III. Blood 5ml was withdrawn and assessed for alkaline phosphatase, aspartate transaminase, alanine transaminase and ferritin. De Ritis ratio was calculated and subjected to intergroup comparison. Data was analysed using SPSS 22. Results: Of the 210 subjects, 110(52.4%) were males and 100(47.6%) were females, with 70(33.3%) in each of the three groups. Group I had 38(54.3%) females and 32(45.7%) males with mean age 37.50±4.513. In group II, there were 27(38.6%) females and 43(61.4%) males with mean age 45.86±9.646, while in group III there were 35(50%) females and 35(50%) males with mean age 54.01±9.243. Serum ferritin levels were significantly increased in patient groups II and III compared to control group I (p<0.05). De Ritis ratio was markedly raised in groups II and III compared to group I (p<0.05). Ferritin was significantly correlated to age, weight, height, fasting blood sugar, haemoglobin, alkaline phosphatase, aspartate aminotransferase, alanine transaminase and bilirubin (p<0.05). De Ritis ratio had a significant correlation with body mass index and fasting blood sugar (p<0.05). Conclusion: Serum ferritin and De Ritis ratio were found to be useful diagnostic indicators for non-alcoholic fatty liver disease, highlighting their importance in improving disease screening. Key Words: NAFLD, Non-alcoholic steatohepatitis, Ferritin, SGPT, SGOT.

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Comparison of liver enzymes and sonological grading in nonalcoholic fatty liver

Cited by 6 publications

References 9 publications

Correlation between nonalcoholic fatty liver disease by ultrasound with hepatic veins spectral doppler and aminotransferases

Correlation between nonalcoholic fatty liver disease by ultrasound with hepatic veins spectral doppler and aminotransferases

Sonological grading of non-alcoholic fatty liver and comparison with liver enzymes

Significance of serum ferritin and De Ritis ratio in non-alcoholic fatty liver disease as diagnostic markers

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