Comparison of liver cancer incidence and survival by subtypes across seven high‐income countries

Rutherford, Mark J.; Arnold, Melina; Bardot, Aude; Ferlay, Jacques; De, Prithwish; Tervonen, Hannah; Little, Alana; Bucher, Oliver; Jacques, Nathalie; Gavin, Anna; Engholm, Gerda; Møller, Bjørn; O’Connell, Dianne; Merrett, Neil D.; Parkin, Donald Maxwell; Bray, Freddie; Soerjomataram, Isabelle

doi:10.1002/ijc.33767

Cited by 32 publications

(18 citation statements)

References 27 publications

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“…The augmented effect of novel systemic therapies might be reflected by the significantly improved 1-year survival rates in our study cohort, which is in line with rates previously reported in most other countries [38].…”

Section: Discussionsupporting

confidence: 92%

Changing Epidemiological Trends of Hepatobiliary Carcinomas in Austria 2010–2018

Hucke

Pinter

Hucke

et al. 2022

Cancers

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Using national registries, we investigated the epidemiological trends of hepatobiliary carcinomas in Austria between 2010 and 2018 and compared them to those reported for the periods of 1990–1999 and 2000–2009. In total, 12,577 patients diagnosed with hepatocellular carcinoma (n = 7146), intrahepatic cholangiocarcinoma (n = 1858), extrahepatic cholangiocarcinoma (n = 1649), gallbladder carcinoma (n = 1365), and ampullary carcinoma (n = 559), between 2010 and 2018, were included. The median overall survival of all patients was 9.0 months. The best median overall survival was observed in patients with ampullary carcinoma (28.5 months) and the worst median overall survival was observed in patients with intrahepatic carcinoma (5.6 months). The overall survival significantly improved in all entities over the period 2010–2018 as compared with over the periods of 2000–2009 and 1990–1999. Age-adjusted incidence and mortality rates remained stable for most entities in both, men and women; only in gallbladder carcinoma, the incidence and mortality rates significantly decreased in women, whereas, in men, the incidence rates remained stable and mortality rates showed a decreasing trend. We showed that age-adjusted incidence and mortality rates were stable in most entities, except in gallbladder carcinoma. The overall survival improved in almost all entities as compared with those during 1990–2009.

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Section: Discussionsupporting

confidence: 92%

Changing Epidemiological Trends of Hepatobiliary Carcinomas in Austria 2010–2018

Hucke

Pinter

Hucke

et al. 2022

Cancers

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“…Lastly, we examined jurisdiction-level (ecological) associations between the percentage of patients diagnosed through an emergency presentation and the corresponding, previously reported, 1-year net survival estimates for 2010–14. 1 , 18 For each cancer site, we used a linear regression model treating jurisdiction-level net survival as the outcome and adjusting for jurisdiction-level percentage of emergency presentations and definition type (broad or narrow) used. To maximise statistical power in these analyses, jurisdiction-specific estimates were used for 17 jurisdictions (New Brunswick, Nova Scotia, Prince Edward Island, Manitoba, and Saskatchewan were considered individually, and not as part of a jurisdictional cluster).…”

Section: Methodsmentioning

confidence: 99%

“…The study forms part of the International Cancer Benchmarking Partnership (ICBP), a global collaboration of clinicians, policy makers, researchers, and data experts in 21 jurisdictions in seven countries, seeking to explain cancer survival differences between high-income countries with comprehensive cancer registries, similar health system expenditure, and universal health care, to help improve cancer care and outcomes. 1 , 16 , 17 , 18 …”

Section: Introductionmentioning

confidence: 99%

Risk factors and prognostic implications of diagnosis of cancer within 30 days after an emergency hospital admission (emergency presentation): an International Cancer Benchmarking Partnership (ICBP) population-based study

McPhail

Swann

Johnson

et al. 2022

The Lancet Oncology

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“…Liver resection is the main method used for the treatment of liver cancer, and the potential advantages of laparoscopy, such as minimally invasive technique, fewer complications, and shorter intraoperative hospital stay, have been identified [ 1 , 2 ]. Although patients could get an early diagnosis combined with comprehensive treatment nowadays, due to the tumor’s malignant character, the prognosis of liver cancer remains unsatisfactory [ 3 , 4 ]. Factors such as age, tumor size and tumor number, pathologic TNM stage, and vascular invasion have been identified as factors influencing the prognosis of liver cancer patients [ 5 – 7 ].…”

Section: Introductionmentioning

confidence: 99%

The impact of body mass index on short-term and long-term surgical outcomes of laparoscopic hepatectomy in liver carcinoma patients: a retrospective study

Zhao

Wang²,

Kong

et al. 2022

World J Surg Onc

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Background It was generally accepted that obesity could increase the morbidity and mortality of surgical patients. However, the influence of body mass index (BMI) on short-term and long-term surgical outcomes of laparoscopic hepatectomy (LH) for patients with liver carcinoma remains unclear. The aim of this study was to evaluate the influence of BMI on surgical outcomes. Methods From August 2003 to April 2016, 201 patients with liver carcinoma who underwent LH were enrolled in our study. Based on their BMI in line with the WHO’s definition of obesity for the Asia-Pacific region, patients were divided into three groups: underweight (BMI< 18.5 kg/m2), normal weight (18.5≤BMI< 23 kg/m2), and overweight (BMI≥ 23 kg/m2). Demographics and surgical outcomes of laparoscopic hepatectomy were compared in different BMI stratification. We investigated overall survival and relapse-free survival across the BMI categories. Results Of the 201 patients, 23 (11.44%) were underweight, 96 (47.76%) were normal weight, and 82 (40.80%) were overweight. The overall complication rate in the underweight group was much higher than that in the normal weight and overweight groups (p=0.048). Postoperative complications, underweight patients developed grade III or higher Clavien-Dindo classifications (p=0.042). Among the three BMI groups, there were no significant differences in overall and relapse-free survival with Kaplan-Meier analysis (p=0.104 and p=0.190, respectively). On the other hand, gender, age, liver cirrhosis, bile leak, ascites, and Clavien classification (III-IV) were not independent risk factors for overall and relapse-free survival in multivariable Cox proportional hazards models. Conclusions BMI status does not affect patients with liver carcinoma long-term surgical outcomes concerned to overall survival and relapse-free survival after laparoscopic hepatectomy. However, being underweight was associated with an increased perioperative complication rate, and perioperative careful monitoring might be required after hepatectomy for underweight with liver carcinoma.

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Comparison of liver cancer incidence and survival by subtypes across seven high‐income countries

Cited by 32 publications

References 27 publications

Changing Epidemiological Trends of Hepatobiliary Carcinomas in Austria 2010–2018

Changing Epidemiological Trends of Hepatobiliary Carcinomas in Austria 2010–2018

Risk factors and prognostic implications of diagnosis of cancer within 30 days after an emergency hospital admission (emergency presentation): an International Cancer Benchmarking Partnership (ICBP) population-based study

The impact of body mass index on short-term and long-term surgical outcomes of laparoscopic hepatectomy in liver carcinoma patients: a retrospective study

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