Comparison of Lipid Profile in Patients With and Without Subclinical Hypothyroidism

Ejaz, Mishal; Kumar, Pardeep; Thakur, Murlidhar; Bachani, Parkash; Naz, Sidra; Lal, Kirshan; Shahid, Wajeeha; Shahid, Simra; Jahangir, Maha; Rizwan, Amber

doi:10.7759/cureus.17301

Cited by 13 publications

(10 citation statements)

References 21 publications

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“…Comparing two groups, the VLDL levels were low in the controls and high in the SCH [22]. In another research comparing the lipid profiles of cases with and without SCH, TC and LDL were found to be noticeably higher in cases with SCH than in cases without SCH [23]. In addition, the research of dyslipidemia in SCH and the effect of thyroxin on lipid profile revealed that the mean levels of total cholesterol and LDL were noticeably higher in SCH than in controls.…”

Section: Discussionmentioning

confidence: 99%

Assessment of Cardiovascular Risk Factors and Insulin Resistance in Patients with Subclinical Hypothyroidism

Shafeek

Sawy

Kabbash

et al. 2023

JAMMR

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Background: Overt hypothyroidism is associated with Insulin resistance (IR), accelerated arteriosclerosis and cardiovascular disease (CVD). Although SCH (SCH) is also associated with CVD risk remains controversial. Objective: The present research aimed to assess risk factors for CVD and IR in SCH cases. Methods: Case control study was carried out on 90 participants. The research included two groups; group one included 45 SCH cases and group two (controls) included 45 healthy volunteers. We assessed common lipid variables, fasting blood glucose, fasting insulin, HOMA IR, thyroid profile for all participants. Results: There was highly significant rise in anthropometric measures including body weight, BMI and waist circumference in SCH than controls (P value = <0.001). There was significant rise in systolic and diastolic blood pressure (BP) in SCH than controls (P value = <0.001, 0.001). There was significant rise in triglyceride level, total cholesterol and LDL-C in SCH in comparison to controls (P value = 0.019, <0.001, <0.001) and significant decline in HDL-C in SCH in comparison to controls (P value = 0.011). There was significant positive correlation between TSH level and anthropometric measures, BP, indices of IR, total cholesterol, triglycerides and LDL-C, but significant negative correlation with HDL-C. Conclusion: Our findings suggest that SCH might increase the risk for CVD which explain the needs for early detection and treatment of such individuals.

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Section: Discussionmentioning

confidence: 99%

Assessment of Cardiovascular Risk Factors and Insulin Resistance in Patients with Subclinical Hypothyroidism

Shafeek

Sawy

Kabbash

et al. 2023

JAMMR

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“…First, stratification based on FT 4 and TSH levels indicated that the baseline level of thyroid function could partly affect the therapeutic effect of L-T 4 . This means that the more severe the low FT 4 and high TSH levels are, the greater the improvement in thyroid function following L-T 4 intervention, as seen in patients with clinical hypothyroidism (CH) and subclinical hypothyroidism (SCH) [ 42 , 43 ]. Currently, there is no diagnostic standard for hyperlipidemia during pregnancy [ 44 ].…”

Section: Discussionmentioning

confidence: 99%

Serum lipid profile in relation to free thyroxine and the effect of levothyroxine treatment on lipids in patients with isolated hypothyroxinemia during pregnancy: a single-center retrospective study

Zhao

et al. 2022

Lipids Health Dis

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Background Thyroid function is widely considered a lipid metabolism regulator. However, studies on lipid metabolism in pregnant women with low free thyroxine (FT4) levels are limited and inconclusive. Furthermore, the association between maternal FT4 deficiency and adverse lipid metabolic parameters is unknown. Therefore, we aimed to investigate this association and the effects of levothyroxine (L-T4) treatment on these metabolic indicators. Methods This retrospective study included 164 patients with isolated hypothyroidism (IH) (FT4 levels below the 5th percentile with normal thyroid stimulating hormone levels according to the gestational-specific reference range) and 407 euthyroidism patients (control group who had regular antenatal examinations at Zhejiang Provincial People's Hospital, Hangzhou, China) between January 1, 2019, and December 31, 2020. Patients with IH were divided into levothyroxine (L-treatment group, n = 77) and dietary iodine supplement treatment groups (dietary treatment group, n=87) according to the hospital’s treatment policy and clinical experience. The intervention lasted for at least 8 weeks. Metabolic indicators, including thyroid function and lipid parameters, were collected at least twice before and after the intervention. Other data collected included maternal age, history of abortion, prepregnancy BMI, and gestational weight gain (Fig. 1). Results Compared with the control group, Patients with IH had a higher degree of dyslipidemia, reflected in elevated total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), and apolipoprotein B (Apo B) levels. In IH patients, an inverse correlation was found between FT4 and TG levels, which remained after adjusting for prepregnancy BMI. The L-treatment group demonstrated a significantly slower rate of hypercholesterolemia progression during pregnancy than the dietary treatment group. In addition, there was a relationship between the therapeutic effect and the degree of disease, with the main factors being FT4, TSH and TG levels prior to starting treatment. Conclusions Low FT4 levels were associated with elevated blood lipid levels. Serum FT4 and lipid levels in patients could be improved by medical intervention.

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“…In particular, despite general consensus on the relationship of thyroid hormones and BMI in overt hypothyroidism exists [ 92 ], data on subclinical hypothyroidism (SCH) are controversial. According to the results of a recent cross-sectional study, total cholesterol and LDL levels are significantly higher in patients with SCH [ 93 ]. In addition, a recent meta-analysis has shown a significant association between hypertension and SCH, especially in middle-aged women [ 94 ].…”

Section: Metabolic Syndrome and Male Infertility: Pathophysiological ...mentioning

confidence: 99%

Metabolic Syndrome and Male Fertility: Beyond Heart Consequences of a Complex Cardiometabolic Endocrinopathy

Salvio¹,

Ciarloni²,

Cutini³

et al. 2022

IJMS

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Metabolic syndrome (MetS) is a highly prevalent condition among adult males, affecting up to 41% of men in Europe. It is characterized by the association of obesity, hypertension, and atherogenic dyslipidemia, which lead to premature morbidity and mortality due to cardiovascular disease (CVD). Male infertility is another common condition which accounts for about 50% of cases of couple infertility worldwide. Interestingly, male infertility and MetS shares several risk factors (e.g., smoking, ageing, physical inactivity, and excessive alcohol consumption), leading to reactive oxygen species (ROS) production and increased oxidative stress (OS), and resulting in endothelial dysfunction and altered semen quality. Thus, the present narrative review aims to discuss the pathophysiological mechanisms which link male infertility and MetS and to investigate the latest available evidence on the reproductive consequences of MetS.

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Comparison of Lipid Profile in Patients With and Without Subclinical Hypothyroidism

Cited by 13 publications

References 21 publications

Assessment of Cardiovascular Risk Factors and Insulin Resistance in Patients with Subclinical Hypothyroidism

Assessment of Cardiovascular Risk Factors and Insulin Resistance in Patients with Subclinical Hypothyroidism

Serum lipid profile in relation to free thyroxine and the effect of levothyroxine treatment on lipids in patients with isolated hypothyroxinemia during pregnancy: a single-center retrospective study

Metabolic Syndrome and Male Fertility: Beyond Heart Consequences of a Complex Cardiometabolic Endocrinopathy

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