Comparison of limited and anatomic hepatic resection for hepatocellular carcinoma with hepatitis C

Kaibori, Masaki; Matsui, Yoshihiko; Hijikawa, Takeshi; Uchida, Yoichiro; Kwon, A‐Hon; Kamiyama, Yasuo

doi:10.1016/j.surg.2005.08.035

Cited by 101 publications

(74 citation statements)

References 41 publications

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“…Thus, when HCC just located within one segment without macrovascular invasion, AR was not supposed to be superior to NAR. Furthermore, Kaibori et al (2006) pointed that central tumors which were near the liver hilum or major vessels should be resected by nonanatomic resection rather than anatomic resection, because it was too hard to obtain an adequate margin.…”

Section: 1771 Anatomic Resection Versus Nonanatomic Resection For Hcmentioning

confidence: 99%

Recurrence after Anatomic Resection Versus Nonanatomic Resection for Hepatocellular Carcinoma: A Meta-analysis

Miao²,

Wu³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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The impact of anatomic resection (AR) as compared to non-anatomic resection (NAR) for hepatocellular carcinoma (HCC) as a factor for preventing intra-hepatic and local recurrence after the initial surgical procedure remains controversial. A systematic review and meta-analysis of nonrandomized trials comparing anatomic resection with non-anatomic resection for HCC published from 1990 to 2010 in PubMed and Medline, Cochrane Library, Embase, and Science Citation Index were therefore performed. Intra-hepatic recurrence, including early and late, and local recurrence were considered as primary outcomes. As secondary outcomes, 5 year survival and 5 year disease-free survival were considered. Pooled effects were calculated utilizing either fixed effects or random effects models. Eleven non-randomized studies including 1,576 patients were identified and analyzed, with 810 patients in the AR group and 766 in the NAR group. Patients in the AR group were characterized by lower prevalence of cirrhosis, more favorable hepatic function, and larger tumor size and higher prevalence of macrovascular invasion compared with patients in the NAR group. Anatomic resection significantly reduced the risks of local recurrence and achieved a better 5 years disease-free survival. Also, anatomic resection was marginally effective for decreasing the early intra-hepatic recurrence. However, it was not advantageous in preventing late intra-hepatic recurrence compared with non-anatomic resection. No differences were found between AR and NAR with respect to postoperative morbidity, mortality, and hospitalization. Anatomic resection can be recommended as superior to non-anatomic resection in terms of reducing the risks of local recurrence, early intra-hepatic recurrence and achieving a better 5 year disease-free survival in HCC patients.

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Section: 1771 Anatomic Resection Versus Nonanatomic Resection For Hcmentioning

confidence: 99%

Recurrence after Anatomic Resection Versus Nonanatomic Resection for Hepatocellular Carcinoma: A Meta-analysis

Miao²,

Wu³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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“…Clear evidence of the superiority of one technique over the other is not available since some studies have attributed a survival benefit to AR (26,27) while others have not (28,29). Two recent meta-analyses of observational studies have also reported conflicting results (30,31).…”

Section: Anatomical Vs Non-anatomical Resectionmentioning

confidence: 99%

Recent advances in surgical treatment of hepatocellular carcinoma

Song

2015

DD&T

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“…Some studies [5,[12][13][14][15] have demonstrated the superiority of AR over non-anatomic resection (NAR) for HCC. However, the optimum liver resection technique in patients with liver dysfunction remains controversial, and there is no clear evidence that AR results in better long-term survival than does NAR [16][17][18][19]. Most of these reported studies had limited statistical power, and no case-matched or randomized clinical trials have compared the outcomes of AR and NAR for treatment of HCC.…”

Section: Introductionmentioning

confidence: 99%

Comparison of anatomic and non‐anatomic hepatic resection for hepatocellular carcinoma

Kaibori

Kon

Kitawaki

et al. 2017

J Hepato Biliary Pancreat

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Background The aim of the present study was to compare the prognostic impact of anatomic resection (AR) versus non-anatomic resection (NAR) on patient survival after resection of a single hepatocellular carcinoma (HCC). Methods To control for confounding variable distributions, a 1-to-1 propensity score match was applied to compare the outcomes of AR and NAR. Among 710 patients with a primary, solitary HCC of <5.0 cm in diameter that was resectable by either AR or NAR from 2003 to 2007 in Japan and Korea, 355 patients underwent NAR and 355 underwent AR of at least one section with complete removal of the portal territory containing the tumor. Results Overall survival (OS) was better in the AR than NAR group (hazard ratio 1.67, 95% confidence interval 1.28-2.19, P < 0.001) while disease-free survival showed no significant difference. Significantly fewer patients in the AR than NAR group developed intrahepatic HCC recurrence and multiple intrahepatic recurrences. Patients with poorly differentiated HCC who underwent AR had improved disease-free survival and OS. Conclusions Anatomic resection decreases the risk of tumor recurrence and improves OS in patients with a primary, solitary HCC of <5.0 cm in diameter.

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Comparison of limited and anatomic hepatic resection for hepatocellular carcinoma with hepatitis C

Cited by 101 publications

References 41 publications

Recurrence after Anatomic Resection Versus Nonanatomic Resection for Hepatocellular Carcinoma: A Meta-analysis

Recurrence after Anatomic Resection Versus Nonanatomic Resection for Hepatocellular Carcinoma: A Meta-analysis

Recent advances in surgical treatment of hepatocellular carcinoma

Comparison of anatomic and non‐anatomic hepatic resection for hepatocellular carcinoma

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