Comparison of levels of large and small high-density lipoprotein cholesterol in Asian Indian men compared with Caucasian men in the Framingham Offspring Study

Bhalodkar, Narendra C.; Blum, Steve; Rana, Thakor; Bhalodkar, Ami; Kitchappa, R.; Kim, Kyoung-Sil; Enas, E. A.

doi:10.1016/j.amjcard.2004.08.040

Cited by 72 publications

(45 citation statements)

References 10 publications

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“…The protocol of present study was approved by ethics committee of VIMS, RKMSP. Laboratory assays: Venous blood samples from the cases and controls were obtained and plasma levels of lipid profile, homocysteine, vitamin B 12 and folic acid were assayed by the standard procedure. Normal range of homocysteine levels was 5-15 µ mol/l.…”

Section: Methodsmentioning

confidence: 99%

“…1 Folate and vitamin B 12 are essential components for the metabolic pathways for decreasing the serum homocysteine concentrations which occurs through remethylation to methionine or trans-sulfuration to cysteine. In this metabolic pathway the enzyme methylenetetrahydro-folate-reductase (MTHFR) is responsible for the reduction of 5,10-methylene-THF to 5-methyl-THF, where vitamin B 12 acts as a cofactor.…”

Section: Introductionmentioning

confidence: 99%

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Homocysteine-Is there any role in Coronary Heart Disease?

Ghosh¹,

Sanchita²,

Kumar³

et al. 2017

JCDR

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Purpose: To test the hypothesis that the coronary heart disease is associated with high serum homocysteine and low vitamin B-12, and folic acid concentrations. Methods: In this population-based case control study, 116 coronary artery diseases with appropriate ECG and/or Echo findings and 96 controls without abnormal ECG and/or Echo findings were selected as the study population. Results: The mean value of serum homocysteine levels of the cases (16.88 μ mol/L ± 10.84) was not significantly higher than the values of the control group (14.18 ± 4.19 μ mol/L) (p=0.02). The mean value of folic acid levels was lower both in male and female cases than that in controls but this difference was also not statistically significant (p= 0.51& 0.05).The mean B12 level also showing higher level in male and female cases but not significantly higher than those of their control group (p=0.48 & 0.62 ). Serum lipid profile [Total Cholesterol TCHL, Low density lipoproteins (LDL), High density lipoproteins (HDL), Triglyceride (TG)] was also found to be inadequate as a potential predictive risk factor in this particular population. Conclusion: These results do not support the hypothesis that coronary heart disease is related to high serum homocysteine concentration. The results are not conclusive due to inability to adequately control for potential confounders as well as inadequate sample size.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Homocysteine-Is there any role in Coronary Heart Disease?

Ghosh¹,

Sanchita²,

Kumar³

et al. 2017

JCDR

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show abstract

“…Several studies that examined the CAD risk factors in this population showed an interplay between the metabolic, genetic, environmental and social settings. However, there have been concerns over the external validity of this data since most of these studies looked at migrant Asian Indian population (5). Since this population enters an availability bias, extrapolation of this data to native Asian Indians could be erroneous (6).…”

Section: Introductionmentioning

confidence: 99%

Asian-Indians: a review of coronary artery disease in this understudied cohort in the United States

Ardeshna¹,

Bob‐Manuel²,

Nanda³

et al. 2018

Ann. Transl. Med.

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Coronary artery disease (CAD) is a major cause of cardiovascular death worldwide. Prevalence of CAD is highly variable among different races. Asian Indians have been noted to have the highest CAD rates and the conventional risk factors fail to explain this difference completely. Asian Indians constitute a fifth of the global population, and the higher rates of CAD in this population constitute a major health challenge.There have been studies in the early 2000s that investigate the risk factors in this population; however, very few studies have been done since then that explore the higher CAD rates in Asian Indians. This is a comprehensive and current review of the known risk factors for CAD in Asian Indians and strategies physicians should consider relieving this burden.

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“…In fact, in diabetic patients, there was no significant difference in the mean projected 'risk' between patients with ACS and patients without any manifestation of CHD (Guha et al, 2004). It has been emphasized also that dyslipidaemia is a silent killer and increased the risk to develop CHD prematurely (Enas et al, 2003;Bhalodkar et al, 2004;Yusuf et al, 2004). The prevalence of T2DM and/or dyslipidaemia, on the other hand, are high for Asian Indians both in India (Gupta and Gupta, 1996;Ramachandran et al, 2001;Kutty et al, 2002;Gupta et al, 2004) and abroad (Deurenberg-Yap et al, 2001;Ho et al, 2001;Bhalodkar et al, 2004;Yusuf et al, 2004;Ezenwaka and Kalloo, 2005) and in turn emphasized the effective managements including nutrients profiling to identify individual who are at greater risk from dyslipidaemia and/or T2DM.…”

Section: Introductionmentioning

confidence: 99%

Comparison of anthropometric, metabolic and dietary fatty acids profiles in lean and obese dyslipidaemic Asian Indian male subjects

Ghosh

2006

Eur J Clin Nutr

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Objectives: To compare obesity measures, metabolic profiles and dietary fatty acids in lean and obese dyslipideamic Asian Indian male subjects. Design: Cross-sectional. Settings: Asian Indians living in the eastern part of India. Subjects: One hundred and thirty (Group I: lean control, n ¼ 50; Group II: lean dyslipidaemic, n ¼ 40 and Group III: obese dyslipidaemic, n ¼ 40) Asian Indian male subjects (X30 years) living in the eastern part of India. Methods: Anthropometric measures namely height, weight, circumferences of waist (WC) and hip, lipids (total cholesterol (TC) and triglycerides (TG)), lipoproteins (high-(HDL) and low-density lipoproteins (LDL)), fasting plasma glucose (FPG) and dietary fatty acids were obtained from each participant. Obesity measures, that is, body mass index (BMI), waist-hip ratio (WHR) and conicity index (CI) were subsequently calculated from anthropometric measures. Obesity was defined as individuals having BMIX25 kg/m 2 . Subjects with one or more of the following conditions were considered as dyslipidaemic: TGX2.3 mmol/l, TCX6.2 mmol/l, or TC/HDLX4.4 mmol/l. Daily intake of nutrients as well as saturated (SFA), monounsaturated (MUFA) and polyunsaturated fatty acids (PUFA) were estimated by adding together all the foodstuffs consumed on weekly and monthly manner. Conversion of foodstuffs into nutrients was performed according to standard nutritive values of Indian foodstuffs. Results: Analysis of variance with Scheffe's post hoc test revealed that Group I had significantly lower mean compared to both Group II and Group III for age, WC, WHR, CI, TC, TG, LDL, FPG, total carbohydrates intake and intake of trans fatty acids. On the other hand, Group I had significantly lower mean than Group III only for BMI as well as intake of total proteins, total fats, total energy and erucic acids. Although, Group I had significantly greater mean compared to both Group II and Group III for HDL, UFA/SFA, MUFA/SFA and PUFA/SFA. Pearson's partial correlations (controlling for age and total energy) revealed that central obesity measures (WC, WHR and CI) had significant association with dietary fatty acids and their ratios. Furthermore, partial correlations (controlling for age) also showed that the ratios of unsaturated to SFA had significant negative association with lipids, lipoproteins (except HDL) and plasma glucose. Discriminant function analysis revealed that overall 78% of all entries were positively (correctly) classified in three groups using fatty acids and their ratios. Conclusion: It seems rational to argue that while dealing with dyslipidaemic Asian Indians, clinicians should consider obesity measures, metabolic profiles and dietary fatty acids simultaneously to better comprehend the condition (s).

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Comparison of levels of large and small high-density lipoprotein cholesterol in Asian Indian men compared with Caucasian men in the Framingham Offspring Study

Cited by 72 publications

References 10 publications

Homocysteine-Is there any role in Coronary Heart Disease?

Homocysteine-Is there any role in Coronary Heart Disease?

Asian-Indians: a review of coronary artery disease in this understudied cohort in the United States

Comparison of anthropometric, metabolic and dietary fatty acids profiles in lean and obese dyslipidaemic Asian Indian male subjects

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