Comparison of late gastrointestinal and genitourinary toxicity of prostate cancer patients undergoing intensity-modulated versus conventional radiotherapy using localized fields

Abstract

To compare late genitourinary (GU) and gastrointestinal (GI) toxicity of radiotherapy (RT) to localized fields for prostate cancer delivered using intensity-modulated RT (IMRT) versus conventional RT (ConvRT). The records of 461 patients were reviewed; 355 patients received IMRT and 106 received ConvRT. Late GU and GI toxicity were compared. Late GU toxicity rates were not significantly different (P ¼ 0.166); however, late GI toxicity rates were lower with IMRT (P ¼ 0.001). Regression analyses demonstrated that only IMRT use (P ¼ 0.006) predicted reduction in late GI toxicity but no factors correlated with late GU toxicity. IMRT did not influence late GU toxicity but was associated with a reduction of late GI toxicity over ConvRT.

Toxicity Analysis of Postoperative Image-Guided Intensity-Modulated Radiotherapy for Prostate Cancer

“…Although the use of intensity-modulated radiation therapy (IMRT) in the definitive radiotherapy setting for localized prostate cancer has been extensively studied (11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21), data in the postoperative setting are more limited (22)(23)(24)(25)(26)(27)(28)(29). In part, this has been due to concerns regarding the cumulative toxicity from any form of postoperative radiotherapy.…”

Management of Complications of Prostate Cancer Treatment

“…As expected, an associated decrease in chronic gastrointestinal morbidity was also noted. 89 Proton-beam therapy has recently gained popularity as an EBRT modality. Based on their physical characteristics, protons also offer the potential advantage of reducing morbidity while providing equivalent levels of cure.…”

Re: Ulike retningslinjer for behandling av prostatakreft

“…IMRT er undersøkt i ikke randomiserte studier hvor man har vist en reduksjon i akutte og sene ano-rektale bivirkninger sammenlignet med konvensjonell strålebehandling (Jani et al, 2007a,Jani et al, 2007b. Imidlertid er det ikke vist tilsvarende fordel for bivirkninger fra urinveiene.…”