Comparison of laser and ozone treatments on oral mucositis in an experimental model

Abstract

Oral mucositis (OM) induces severe pain and limits fundamental life behaviors such as eating, drinking, and talking for patients receiving chemotherapy or radiotherapy. In addition, through opportunistic microorganisms, OM frequently leads to systemic infection which then leads to prolonged hospitalization. Severe lesions often adversely affect curative effects in cancer cases. Therefore, the control of OM is important for oral health quality of life and prognosis. Low-level laser therapy (LLLT) and ozone may be useful to accelerate wound healing. In this study, 24 Sprague-Dawley rats were divided into three groups as control, ozone, and laser groups. All groups received 5-fluorouracil intraperitoneally and trauma to the mouth pouch with a needle. After the formation of OM in the mouth, the control group had no treatment; the ozone group was administered ozone, and the laser group, LLLT. Then, all groups were sacrificed and basic fibroblast growth factor (bFGF), transforming growth factor (TGF-β), and platelet-derived growth factor (PDGF) were evaluated in all groups. LLLT was determined to be statistically significantly more effective than ozone on FGF and PDGF. However, in respect of TGF-β, no statistically significant difference was observed between the groups. In conclusion, within the limitations of this study, LLLT is more effective than ozone. However, further studies on this subject are required.

Peroxisome proliferator activated receptor‐gamma stimulation for prevention of 5‐fluorouracil‐induced oral mucositis in mice

“…Oral mucositis occurs in 40%‐70% of patients undergoing chemotherapy with a higher rate of >90% in children . This condition directly affects patients' quality of life due to severe oral pain and swallowing and speaking difficulties, resulting in impaired nutrition, dehydration, and weight loss . Moreover, mucositis can adversely affect the curative effects of chemotherapy due to the increased risk of local and systemic infections, which may lead to discontinuation of chemotherapy or dose reductions that can potentially cause a decrease in patient survival …”

“…2,3 This condition directly affects patients' quality of life due to severe oral pain and swallowing and speaking difficulties, resulting in impaired nutrition, dehydration, and weight loss. 4,5 Moreover, mucositis can adversely affect the curative effects of chemotherapy due to the increased risk of local and systemic infections, which may lead to discontinuation of Mariangela chemotherapy or dose reductions that can potentially cause a decrease in patient survival. 3,5,6 Although the exact pathogenesis of mucositis is still unclear, the etiological process of oral mucosal damage has been described in a 5-phase model.…”

The effects of ozone therapy on wound healing after gingivectomy operations: a controlled clinical study

“…Ozon tedavisi antibakteriyel, antioksidan ve konak modülatör özellikleri sebebiyle öne çıkmaktadır 8,9,12,14,15,[22][23][24][25][26] . Bu özellikleri destekleyecek şekilde, elimizdeki sonuçlar ozon uygulanan bölgelerde kontrol tarafıyla kıyaslandığında yara iyileşmesinin daha iyi olduğunu göstermiştir.…”

“…Az sayıda da olsa, ozonun yara iyileşmesi üzerinde herhangi bir etkisi olmadığını bildiren çalışmalar da mevcuttur. Bayer ve ark., güçlü iyileşme indikatörleri olarak düşünülen ozon tedavisinin fibroblast büyüme faktörü, TGF-β ya da platelet kaynaklı büyüme faktörünü artırmadığını bildirdi 25 . Ek olarak, Mutluoglu ve ark.…”

Effects of alloplastic graft material combined with a topical ozone application on calvarial bone defects in rats

“…Clinically, the importance of ossification and fracture healing is well known in rats. It has been reported that exposure to ozone application provides good healing in diabetes (15), oral mucositis (16), surgical treatment of peri-implantitis (17), bone regeneration (18,19), and osteogenesis with calvarial defects in experimental models (20). Many rodent experimental animals, including rats, have been used to design bone defect models (21)(22)(23)(24).…”