Comparison of lansoprazole‐based triple and dual therapy for treatment of Helicobacter pylori‐related duodenal ulcer: an Asian multicentre double‐blind randomized placebo controlled study

Abstract

This Asian multicentre study showed that 1-week lansoprazole-based triple therapy without clarithromycin has similar efficacy in H. pylori eradication and ulcer healing compared with a 2-week regimen. Both triple therapies were significantly better than dual therapy in H. pylori eradication. Therefore, 1-week lansoprazole-based triple therapy is as safe and effective as 2-week therapy in eradication of H. pylori infection and healing of duodenal ulcer in these Asian centres.

Comparison of 1 and 2 weeks of omeprazole, amoxicillin and clarithromycin treatment for Helicobacter pylori eradication: the HYPER Study

“…25 Just one multicentre study has compared the efficacy of 1 week and 2 weeks of triple therapy, but this study used metronidazole rather than clarithromycin in association with amoxicillin. 26 Triple therapy with metronidazole and amoxicillin is recognised as having lower efficacy compared with PPI and clarithromycinbased triple therapies and so it is not recommended by guidelines as part of triple therapy for H pylori eradication. [7][8][9] The problem of small patient numbers has led some investigators to conduct meta-analyses, which can be helpful because they represent a formal method for pooling large groups of patients from different studies.…”

Clinical trial: levofloxacin‐based quadruple therapy was inferior to traditional quadruple therapy in the treatment of resistant Helicobacter pylori infection

“…5,6 Levofloxacin-based therapy is recently found to be an effective alternative triple therapy for H. pylori eradication, and is comparable or better than traditional quadruple therapy. [7][8][9][10][11][12][13][14][15] However, a recent local study showed that levofloxacin-based triple therapy and traditional quadruple therapy eradicated H. pylori infection in only 57% and 71% of resistant cases, respectively.…”

Efficacy and Safety of Faropenem in Eradication Therapy of Helicobacter pylori

“…The eradication rate by dual therapy with lansoprazole (60 mg/day) and amoxicillin (2000 mg/day) for 14 days was reported by Wong et al. to be 58.9% (43/73) according to a PP analysis [33]. Although the difference with the dual therapy was not significant, the eradication rate of triple therapy with faropenem in that study was 78.3%.…”