Comparison of lansoprazole and omeprazole in the short‐term management of duodenal ulcers in Taiwan

Chang, Full Young; Chiang, Cheng-Yi; Tam, Tseng-Nip; Ng, Wai-Wah; Lee, S D

doi:10.1111/j.1440-1746.1995.tb01352.x

Cited by 13 publications

(8 citation statements)

References 30 publications

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“…Diarrhoea, and not constipation, caused by diminishing chloride output from the stomach and a reduction of faecal water (as in congenital chloride diarrhoea; Aichbichler 1997) is also usually observed as side‐effect. However, other studies have suggested that constipation is increased or worsened after starting PPIs (Chang et al 1995; Garrigues et al 1996). A systemic testing of bowel function in the population with colonic manometry and the influence of drugs has not yet been performed.…”

Section: Discussionmentioning

confidence: 98%

The prevalence of constipation in institutionalized people with intellectual disability

Böhmer

Taminiau

Klinkenberg‐Knol

et al. 2001

J intellect Disabil Res

106

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Constipation is a common problem in people with intellectual disability (ID). Laxatives are frequently prescribed with disappointing results. The prevalence of constipation was investigated in a random population of 215 people with ID (IQ < 50) and constipation was correlated with clinical symptoms. All subjects were scored for bowel habits. Constipation was defined as having a bowel movement less than three times a week or the necessity of using laxatives more than three times a week. Further possible accompanying factors were evaluated. The control subjects were defined as individuals who did not use laxatives. Subjects with constipation were defined as patients and were compared to subjects without constipation (controls). One hundred and forty-nine out of 215 cases (69.3%) showed constipation. Constipation was significantly correlated with non-ambulancy, cerebral palsy, the use of anticonvulsive medication or benzodiazepines, H2-receptor antagonists or proton pump inhibitors, food refusal, and an IQ < 35. Fifty-eight per cent of the patients used bisacodyl or magnesium oxide, 39% lactulose, 13% sodiumlaurylsulphoacetate/sodium citrate/sorbitol and only 10% were given sodium phosphate enemas. Faecal soiling was found in 15% of subjects, while manual evacuation of faeces was performed in nearly 7% of cases. Constipation was randomly demonstrated in almost 70% of the population with ID. Subjects with the above-mentioned accompanying factors are especially at risk for constipation. Contrary to the general population, constipation in people with ID is associated with little use of phosphate enemas, microlax, a low incidence of faecal soiling and manual evacuation of faeces, suggesting an aetiology without distal faecal impaction. The regimen and effect of therapy has to be studied to define adequate treatment schedules.

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Section: Discussionmentioning

confidence: 98%

The prevalence of constipation in institutionalized people with intellectual disability

Böhmer

Taminiau

Klinkenberg‐Knol

et al. 2001

J intellect Disabil Res

106

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“…Short-term daily omeprazole consumption delays solid GE in normal subjects [24][25][26][27][28]. On the other hand, lansoprazole, another proton pump inhibitor showing similar ulcer healing ability, has no effect on solid GE [29,30]. Perhaps variations in GE measurement, test meal, period of omeprazole premedication and studied subjects may account for these contradictory results.…”

Section: Discussionmentioning

confidence: 99%

The Pharmacological Effect of Omeprazole on Water Gastric Emptying: A Study Based on an Impedance Measure

Chang

Chen

et al. 2001

Pharmacology

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The present study was performed to validate the accuracy of a self-designed applied-potential tomograph (APT) in measuring the cross area of a studied object and to assess the effect of omeprazole premedication on water gastric emptying (GE), based on APT. Twelve electrodes were evenly placed in a circular array around the studied subjects. Ten electrodes in a rotated order recorded the electrical current injected into paired electrodes. Based on tomography, averaged signals of changed resistivity were constructed to display the area of interest and GE curve. Six beakers of various diameters were respectively placed into a cylindrical perspex tank which was filled with saline to measure their cross areas via computer-generated diagrams of APT. One hour after either omeprazole (20 mg) or placebo premedication, 15 healthy males were ordered to consume 500 ml of test water to assess emptying for 40 min. Within 3 days, a similar procedure was repeated using the counterpart premedication. The true cross areas of the 6 beakers are 2.01, 15.9, 18.8, 30.19, 38.48 and 63.61 cm², whereas those obtained by APT were 7.9 ± 2.9, 16.7 ± 3.3, 22.4 ± 4.9, 28 ± 4.8, 48.7 ± 7.6 and 67 ± 6.1 cm², respectively (r = 0.98, p < 0.001). Valid emptying data were obtained in 73.3 and 86.6% of subjects, following placebo and omeprazole, respectively (not significant). The half emptying times were 12.7 ± 5.1 min for the placebo-treated group and 10.5 ± 3.6 min for the omeprazole-treated group, respectively (p < 0.05). The areas under the emptying curve were 1,611.5 ± 357.6 and 1,317.3 ± 316.7 arbitrary units, respectively (p < 0.01). In conclusion, our APT system is accurate for large-area measurements; acid inhibition before APT measurement does not increase the success rate but enhances water emptying. The interpretation of impedance-obtained GE should consider the acid-inhibitory effect.

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“…Several studies have compared lansoprazole with omeprazole in the treatment of acute duodenal ulcer 82 –86 . None of these studies have shown a statistically significant difference in healing rates at 4 weeks, although in two studies lansoprazole 30 mg was associated with an increased healing rate at 2 weeks compared with omeprazole 20 mg 85 –86 .…”

Section: Efficacymentioning

confidence: 99%

Review article: comparison of the pharmacokinetics, acid suppression and efficacy of proton pump inhibitors

Stedman

Barclay

2000

Aliment Pharmacol Ther

290

228

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Proton pump inhibitors have dramatically influenced the management of acid‐peptic disorders in recent years. They all have a broadly similar mechanism of action and are extensively metabolized in the liver via cytochromes P450 2C19 and 3A4. There is some variation in their potential for drug interactions due to differences in enzyme inhibition. Relatively few serious adverse effects have been reported for the proton pump inhibitors. Comparative studies of acid suppression suggest that lansoprazole and pantoprazole have a potency similar to that of omeprazole on a mg for mg basis; however, rabeprazole may have a greater potency than omeprazole. Lansoprazole and rabeprazole display a more rapid onset of maximal acid suppression than the other proton pump inhibitors. Comparative studies using proton pump inhibitors for the treatment of reflux oesophagitis, duodenal ulcer healing and Helicobacter pylori eradication show little overall difference in outcome between the proton pump inhibitors when used in their standard doses. Lansoprazole and rabeprazole provide earlier and better symptom relief than the other proton pump inhibitors in some studies of peptic ulcer treatment. The few studies of gastric ulcer treatment suggest that there is an advantage in using the proton pump inhibitors that have a higher standard daily dose.

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Comparison of lansoprazole and omeprazole in the short‐term management of duodenal ulcers in Taiwan

Cited by 13 publications

References 30 publications

The prevalence of constipation in institutionalized people with intellectual disability

The prevalence of constipation in institutionalized people with intellectual disability

The Pharmacological Effect of Omeprazole on Water Gastric Emptying: A Study Based on an Impedance Measure

Review article: comparison of the pharmacokinetics, acid suppression and efficacy of proton pump inhibitors

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