Comparison of Lacrimal and Salivary Gland Involvement in Sjögren's Syndrome

Vissink, Arjan; Kalk, W; Mansour, Khaled; Spijkervet, Fred K. L.; Bootsma, Hendrika; Roodenburg, Jan; Kallenberg, Cees G. M.; Amerongen, A. van Nieuw

doi:10.1001/archotol.129.9.966

Cited by 33 publications

(15 citation statements)

References 18 publications

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“…Researchers have made repeated attempts to determine the relationship between prognostic factors and ocular manifestations in SS. Toker et al 3 found a significant correlation between tear anti-La/SSB concentrations and rose bengal staining scores, and Vissink et al 17 demonstrated a positive correlation between the presence of La/SSB autoantibody in serum and rose bengal staining scores, which corresponds well with our results. The present study shows that a significant elevation of Ro/SSA and La/SSB autoantibodies in the sera of moderate to severe KCS in SS.…”

Section: Discussionsupporting

confidence: 92%

Prognostic factors for the clinical severity of keratoconjunctivitis sicca in patients with Sjögren's syndrome

2011

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Section: Discussionsupporting

confidence: 92%

Prognostic factors for the clinical severity of keratoconjunctivitis sicca in patients with Sjögren's syndrome

2011

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“…Although the vital staining exhibited the highest likelihood ratio in this study, in agreement with previous works that indicated vital dye score the test of choice, 21 the complessive diagnostic performance was scarce in our study, as it can be seen in the ROC plot analysis flat curve, probably as a consequence of a bias in data collection, since vital dye staining was applied only to those patients with Fluo negative corneas.…”

Section: Eyesupporting

confidence: 89%

Diagnostic performance of tear function tests in Sjogren's syndrome patients

Versura

Frigato

Cellini

et al. 2006

Eye

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Objective To evaluate the diagnostic performance of the tests included in primary Sjogren's syndrome (SS-I) diagnostic criteria (Schirmer I, break-up time, vital dye staining) and to compare them with other examinations related to the ocular surface status. Methods Clinical and cytological data were collected from 177 patients (62 SS-1, 56 non-SS autoimmune diseases, 59 Sicca syndrome). Tear tests included: a validated questionnaire on symptoms, Schirmer I, Jones test, Ferning test, BUT, corneal aesthesiometry, tear clearance test, lissamine green staining, impression conjunctival cytology. Data were statistically evaluated and sensitivity, specificity, likelihood ratio (LR þ ), receiveroperating characteristics (ROC) curves were calculated for each test. Results Data showed a poor diagnostic performance of Schirmer test I (sensitivity 0.42; specificity 0.76; LR þ 1.75) and BUT (sensitivity 0.92; specificity 0.17; LR þ 1.11) (area under the curve in ROC analysis o0.58). Validated subjective symptoms questionnaire (sensitivity 0.89; specificity 0.72; LR þ 3.18), Jones test (sensitivity 0.60; specificity 0.88; LR þ 5), corneal aesthesiometry (sensitivity 0.80; specificity 0.67; LR þ 2.42), and tear clearance test (sensitivity 0.63; specificity 0.84; LR þ 3.93), all exhibited a high diagnostic performance (area under the curve in the ROC analysis always 40.70). Lissamine green staining exhibited the best performance (sensitivity 0.63; specificity 0.89; LR þ 5.72) but the result could be distorted by an incorporation bias. Conclusions Our data suggest to implement the items for ocular signs and symptoms contained in many SS-I diagnostic criteria with the use of a validated questionnaire, performance of Jones test, corneal aesthesiometry measurement, and tear clearance rate evaluation.

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“…The median value of PFR in the MALT‐L group was reduced compared with the SS‐low risk subgroup. UWSFR and PFR showed a strong correlation ( r = 0.6, p < 0.0001) in concordance to Kalk, Mansour, et al () and Vissink et al () ( r = 0.75, p < 0.001). However, it appears that parotid gland involvement is more evident in later stages of SS when there may be little correlation between whole mouth and parotid flow rates.…”

Section: Discussionsupporting

confidence: 86%