Comparison of Laboratory Values Obtained by Phlebotomy versus Saline Lock Devices

Corbo, Jill; Fu, Lequan; Silver, Matthew; Atallah, Hany; Bijur, Polly E.

doi:10.1111/j.1553-2712.2007.tb00365.x

Cited by 12 publications

(24 citation statements)

References 6 publications

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“…Differences in blood sampling methods and their effect on laboratory results have been analyzed repeatedly in the human medical literature. Specifically, sampling via direct venipuncture versus from a peripheral venous catheter has been found to have no effect on the accuracy of coagulation profiles 1 or electrolyte results, 2,3 and causes minimal hemolysis in samples drawn from large bore catheters 4 . These finding were consistent even after fluid administration through the sampled IVC 5 .…”

mentioning

confidence: 99%

Comparison of Hematologic and Biochemical Results on Blood Obtained by Jugular Venipuncture as Compared with Intravenous Catheter in Adult Horses

May

Nolen-Walston

Utter

et al. 2010

Journal of Veterinary Internal Medicine

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Background: During hospitalization, horses typically undergo frequent blood sampling for diagnostic testing and monitoring. The need for numerous samples in hospitalized horses makes acquisition from an intravenous catheter (IVC) both convenient and less stressful to the patient.Hypothesis: We hypothesized that there would be no significant difference in the plasma chemistry and CBC variables from blood samples obtained from a jugular catheter as compared with direct jugular venipuncture.Animals: Fifty adult hospitalized horses; 25 receiving constant rate crystalloid therapy, and 25 receiving low volume IV medication.Methods: This study was conducted using a prospective, blinded, cross-over design. Samples were obtained sequentially by direct venipuncture of the jugular vein and aspiration from an IVC in the contralateral vein after an appropriate presample of blood was obtained and discarded. Samples were submitted for blinded analysis including CBC, plasma chemistry analysis, stall side plasma glucose concentration, PCV, and total protein concentration. Data obtained were analyzed using a Student's t-test with compensation for unequal variances between the 2 groups. Analyses were Bonferroni corrected for a 5% 2-tailed hypothesis test.Results: There were no statistically significant or clinically relevant differences associated with sampling method (venipuncture versus catheter) regardless of fluid administration status in any of the 24 analytes measured.Conclusions and Clinical Importance: Blood samples obtained by IVC have clinically equivalent values to those taken by direct venipuncture in commonly performed analyses. Additional investigation is warranted to establish if this technique is associated with increased complications such as phlebitis or bacteremia.

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mentioning

confidence: 99%

Comparison of Hematologic and Biochemical Results on Blood Obtained by Jugular Venipuncture as Compared with Intravenous Catheter in Adult Horses

May

Nolen-Walston

Utter

et al. 2010

Journal of Veterinary Internal Medicine

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“…Several studies have analysed the concordance between the laboratory values obtained using DVP and PVC, most using PVCs fitted with saline syringes 6 7. However, their equivalence has been little studied, sometimes with inadequate methodology, by contrasting means testing or the correlation coefficient,19 and at other times using a small sample size 20 21…”

Section: Discussionmentioning

confidence: 99%

“…Collection using DVP was made from the limb opposite to the one with the PVC. For PVC collection, the intravenous fluid therapy line was first closed for 15 s, as was any medication with the PVC three-way valve, and a syringe was adapted, from which 4 mL of blood was discarded, as recommended in recent studies 6 7. Thereafter, the syringe was changed by rotating the valve 1/8 to complete removal.…”

Section: Methodsmentioning

confidence: 99%

A cross-sectional study to compare two blood collection methods: direct venous puncture and peripheral venous catheter

et al. 2014

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ObjectivesTo demonstrate the equivalence between blood collection methods using direct venous puncture (DVP) and a peripheral venous catheter or cannula (PVC).Design and settingA cross-sectional study of simple crossover design with within-subject measures carried out between October 2011 and May 2012 at a regional hospital in Spain.Participants272 patients aged 18 or older hospitalised or admitted to the short-stay unit (SSU) who required laboratory testing and PVC to administer saline solution, intravenous fluid therapy and/or intravenous medication. Excluded were those with PVC collection time exceeding 20 s, difficulty of venoclysis, or who presented with arteriovenous fistula, language difficulties, in critical condition or altered consciousness with no family to consent.Primary and secondary outcome measures18 variables were recorded for DVP and PVC, along with age, sex, diagnosis, vein location for DVP, location of the PVC, PVC calibre, saline syringe, intravenous fluid therapy, medication, haemolysis and clotted blood during DVP or PVC collection. Univariate analysis, Pearson's product-moment correlation coefficient (r), Lin's concordance correlation coefficient (rc) and Bland-Altman's 95% agreement interval were provided.ResultsIncluded in the study were 272 patients, primarily aged 65 or older (80.9%), males (52.6%) and receiving intermittent medication (43.4%). Values obtained with both methods showed a positive linear association, being moderate for pO2 (r=0.405) and very high for all others (r>0.86). Levels were concordant (rc≥0.9), except for calcium (rc=0.860), pH (rc=0.853), pCO2 (rc=0.843) and pO2 (rc=0.336) and equivalent for all determinations except pCO2 and pO2, where clinically significant differences were found in more than 9% of cases (21.2%, 95% CI 16.6% to 26.5% and 73.1%, 95% CI 67.4% to 78.1%).ConclusionsBlood collection methods using DVP and PVC can be used interchangeably for most routine laboratory tests.

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“…The study selection process resulted in 855 studies being identified from the search strategy (Figure ). Based on comparing the title and abstract of the citation against the inclusion criteria, 16 studies were identified as eligible (Barnard et al, ; Corbo, Fu, Silver, Atallah, & Bijur, ; Dietrich, ; Grant, ; Hambleton, Gomez, & Bernabeu Andreu, ; Himberger & Himberger, ; Kelly & Klim, ; Lowe et al, ; Munnix, Schellart, Gorissen, & Kleinveld, ; Ong, Chan, & Lim, ; Ortells‐Abuye, Busquets‐Puigdevall, Díaz‐Bergara, Paguina‐Marcos, & Sánchez‐Pérez, ; Phelan et al, ; Seemann & Reinhardt, ; Self et al, ; Wollowitz, Bijur, Esses, & Gallagher, ; Zlotowski, Kupas, & Wood, ).…”

Section: The Reviewmentioning

confidence: 99%

Drawing blood from peripheral intravenous cannula compared with venepuncture: A systematic review and meta‐analysis

Coventry

Jacob

Davies

et al. 2019

Journal of Advanced Nursing

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Aims To synthesize the evidence evaluating if blood samples are similar when obtained from peripheral intravenous cannula compared with venepuncture. Design A systematic review and meta‐analysis was undertaken. Data sources Searches were conducted in databases for English language studies between January 2000–December 2018. Review methods The search adhered to the Meta‐analysis of Observational Studies in Epidemiology guidelines. The methodological quality of studies was assessed using Joanna Briggs critical appraisal instruments. The overall quality of the evidence was assessed using the GRADE. Results Sixteen studies were identified. Findings suggest haemolysis rates are higher in blood sampled from peripheral intravenous cannula. However, haemolysis rates may be lower if a peripheral intravenous cannula blood sampling protocol is followed. For equivalence of blood test results, even though some results were outside the laboratory, allowable error and were outside the Bland–Altman Level of Agreement, none of these values would have required clinical intervention. With regard to the contamination rates of blood cultures, the results were equivocal. Conclusion Further research is required to inform the evidence for best practice recommendations, including, if a protocol for drawing blood from a peripheral cannula is of benefit for specific patient populations and in other settings. Impact Venepuncture can provoke pain, anxiety and cause trauma to patients. Guidelines recommend blood samples from peripheral intravenous cannula be taken only on insertion. Anecdotal evidence suggests drawing blood from existing cannulas may be a common practice. Further research is required to resolve this issue.

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Comparison of Laboratory Values Obtained by Phlebotomy versus Saline Lock Devices

Abstract: Aspirating blood via an SLD is an acceptable method of obtaining serial laboratory values in a group of stable, consenting adult ED patients.

Cited by 12 publications

References 6 publications

Comparison of Hematologic and Biochemical Results on Blood Obtained by Jugular Venipuncture as Compared with Intravenous Catheter in Adult Horses

Comparison of Hematologic and Biochemical Results on Blood Obtained by Jugular Venipuncture as Compared with Intravenous Catheter in Adult Horses

A cross-sectional study to compare two blood collection methods: direct venous puncture and peripheral venous catheter

Drawing blood from peripheral intravenous cannula compared with venepuncture: A systematic review and meta‐analysis

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