Comparison of Ki-67 proliferative index between eutopic and ectopic endometrium: A case control study

Kahyaoğlu, Serkan; Moraloğlu, Özlem; Zergeroğlu, Sema; Süt, Necdet; Batıoğlu, Sertaç

doi:10.1016/j.tjog.2012.07.013

Cited by 17 publications

(17 citation statements)

References 28 publications

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“…Chronic and progressive inflammation is able to form invasive mass, such as a massive endometriotic cyst in this case. 8,15 This study also shows a significant association between Ki-67 expression and endometriosis stage. Statistical analysis with Somers'd test results in p value of <0.0001 (p<0.05) and correlation coefficient of 0.564, reflecting a significantly strong correlation based on Guilford criteria.…”

Section: Discussionsupporting

confidence: 61%

“…There is a positive correlation between endometriosis stage and Ki-67 expression, this explains the importance of proliferation in progressivity of the disease. 15,16 In more advanced stage of disease, according to AFS score, there would be deeper endometriotic lesions, more adhesion, and obliteration in cavum douglasi. Consistent with the etiopathogenesis of endometriosis, as endometrial cells reach the implantation sites outside uterine cavity by menstrual blood retrograde, lymphogenic, or hematogenic, these cells would adhere and invade ovary or peritoneal structures.…”

Section: Discussionmentioning

confidence: 99%

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Ki-67 Expression is Correlated with Cyst Size and Stage of Endometriosis

Alif¹,

Anwar

Pribadi

2016

Indones J Obstet Gynecol

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Objectives: To analyze the association between Ki-67 expression with the cyst size and stage of endometriosis, and the correlation strength between them. Methods: A cross-sectional analytic observational study involving 56 paraffin blocks from subjects diagnosed with endometriosis, who had undergone laparotomy or laparoscopic surgery. The study is conducted in Dr. Hasan Sadikin Hospital in September-November 2012. Results: Shows a significant association between Ki-67 expression and the size of endometriotic cyst (p < 0.0001), also with a strong correlation (r = 0.55) according to Guilford criteria. There is also a significant association between Ki-67 expression and the endometriosis stage (p < 0.0001), with a strong correlation (r = 0.564) according to Guilford criteria. Conclusion: Ki-67 expression is correlated with the cyst size and stage of endometriosis. [Indones J Obstet Gynecol 2013; 1-3: 124-8] Keywords: endometriosis stage, endometriotic cyst size, Ki-67

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Section: Discussionsupporting

confidence: 61%

Section: Discussionmentioning

confidence: 99%

Ki-67 Expression is Correlated with Cyst Size and Stage of Endometriosis

Alif¹,

Anwar

Pribadi

2016

Indones J Obstet Gynecol

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“…However, contrary to the study by Kahyaoglu et al [16], no correlation was observed between postoperative CA125 levels and the Ki-67 proliferation index (p=0.731). The increase in the Ki-67 proliferation index was also related to a more advanced stage of the disease.…”

Section: Discussioncontrasting

confidence: 93%

“…Kahyaoglu et al [16] compared the Ki67 proliferation index in eutopic and ectopic endometrium and found an increase in the proliferation index as the endometriosis stage increased, in a study of 38 patients with endometriosis and 21 with control group. Furthermore, a correlation between the proliferation index and CA125 levels existed.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the Ki-67 Proliferation Index and Urocortin Expression in Women with Ovarian Endometriomas

Yalçın¹,

Ocal²,

Yalçın³

et al. 2017

Eurasian J Med

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Objective: The reasons why endometriosis is more aggressive and invasive in some patients are unknown. Despite the importance of population-based clinically defined risk factors in the prediction of recurrence, biochemical markers obtained from the patient are more valuable for prediction on an individual basis. Therefore, the discovery of significant potential biomarkers could be useful to clinicians for shedding light on the pathogenesis of endometriosis and in the monitoring recurrence. Materials and Methods:This study included 50 patients who underwent surgery for ovarian cysts that were diagnosed as endometrioma. The age of the patients, stage of the endometriosis, diameter and localization of endometriomas, type of surgery, and pre-and postoperative cancer antigen 125 (CA125) levels were compared between patients with and without recurrence. The archived pathology slides were stained with Ki-67 and anti-urocortin antibodies for reevaluation. By comparing the pathology parameters of the patients with and without recurrence, the association between these parameters and recurrence was investigated.Results: The median Ki-67 proliferation index of the patients with recurrence (7.5±6.5) was statistically significant compared with that of the patients without recurrence (1±4) (p=0.003). The urocortin epithelial staining intensity and percentage were not found to be statistically significant in comparison. A statistically significant difference was determined between postoperative CA125 median levels of patients without recurrence (10±17.6) and those of patients with recurrence (29.9±18.1) (p=0.003). Conclusion:The Ki-67 proliferation index may be useful for predicting prognosis and recurrence risk.Keywords: Endometriosis, Ki-67 proliferation index, urocortin ÖZ Amaç: Endometriozisin bazı hastalarda neden daha agresif ve invaziv olduğunun nedenleri bilinmemektedir. Klinik olarak belirlenen risk faktörleri populasyon bazında rekürrens prediksiyonunda değerli olmasına rağmen kişi bazında prediksiyonda hastadan elde edilen biyokimyasal markerlar daha değerlidir. Bu nedenle, rekürrens açısından anlamlı potansiyel biyomarkerların keşfi endomeriozis patogenezine ışık tutabileceği gibi rekürrens takibinde klinisyenlere yardımcı bir parametre olarak kullanılabilir.Gereç ve Yöntem: Çalışmamıza over kisti nedeniyle cerrahi geçiren ve patolojik inceleme sonucunda endometrioma tanısı konmuş 50 hasta dahil edildi. Olguların yaş, endometriozis evresi, endometrioma çapı ve lokalizasyonu, cerrahi tipi, preoperatif ve postoperatif CA 125 düzeyleri kaydedildi. Olguların arşiv patoloji preparatları Ki 67 ve anti-urocortin antikor ile boyandı. Patolojik parametreler nüks olan olgular ile olmayanlarda kıyaslanarak bu parametrelerin rekürrens ile ilişkisi araştırıldı.Bulgular: Nüks olan olguların Ki67 İndeks medyanı (7,5±6,5) nüks olmayan olguların Ki67 İndeks medyan değerinden (1±4) daha büyük olup, istatistiksel olarak anlamlıydı (p=0,003). Olguların nüks olma durumu ile ürocortin epitel boyanma yoğunluğu ve yüzdesine göre da...

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“…Jika kemampuan proliferasi sel meningkat maka sel tersebut akan mengadakan pertumbuhan yang tak terkendali seperti tumor. Sel tersebut akan menyerang jaringan sekitar sehingga kemudian terjadi perlekatan yang akan mengakibatkan distorsi organ 3,11 Penelitian menunjukkan bahwa ekspresi Ki-67 bergantung pada siklus haid. Penelitian tersebut menyatakan bahwa pada sel endometrium normal, aktivitas proliferasi sel meningkat saat fase proliferasi siklus haid dan menurun pada fase sekresi siklus haid.…”

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