2017
DOI: 10.1136/jclinpath-2017-204616
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Comparison of karyotyping,TCL1fluorescence in situ hybridisation and TCL1 immunohistochemistry in T cell prolymphocytic leukaemia

Abstract: Our study shows that TCL1 by IHC is a convenient test, positive in >80% T-PLL. Conventional cytogenetics is insensitive in the detection of 14q32/ rearrangements but provides more complete information of the chromosomal landscape of T-PLL. FISH for rearrangement is very valuable in diagnostic challenging cases.

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Cited by 13 publications
(6 citation statements)
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“…[358][359][360] TNFAIP3 mutation has been found in ~6% of NK-LGLL. 360,361 T-cell prolymphocytic leukemia (T-PLL) is characterized by chromosomal inversions or translocations involving TCL1 family genes, best demonstrated by FISH, 362 resulting in constitutive overexpression of TCL1A or MCTP1, and found in virtually all cases. [363][364][365] Complex karyotypic abnormalities, present in >70% of cases, portend a poor prognosis.…”
Section: Extranodal Ptclsmentioning
confidence: 99%
“…[358][359][360] TNFAIP3 mutation has been found in ~6% of NK-LGLL. 360,361 T-cell prolymphocytic leukemia (T-PLL) is characterized by chromosomal inversions or translocations involving TCL1 family genes, best demonstrated by FISH, 362 resulting in constitutive overexpression of TCL1A or MCTP1, and found in virtually all cases. [363][364][365] Complex karyotypic abnormalities, present in >70% of cases, portend a poor prognosis.…”
Section: Extranodal Ptclsmentioning
confidence: 99%
“…Detection of aberrant TCL1 protein expression via flow cytometry or immunohistochemistry is more sensitive than cytogenetics and also represents a diagnostic hallmark. 3,22,24,25 Few cases are observed in which neither a rearrangement nor an overexpression of TCL1A, TCL1B, or MTCP1 is detected, but which otherwise carry typical clinical, cytomorphological, and molecular criteria of T-PLL (clonal expansion of cells with a prolymphocytic T-cell phenotype). These cases should be collected for a more comprehensive scientific analysis and labeled as TCL1-family negative T-PLL.…”
Section: Geneticsmentioning
confidence: 99%
“…Inv(14)(q11q32) and t(14;14)(q11;q32) causes juxtaposition of TCRα and TCL1 or TCL1B leading to activation ( 37 ). This rearrangement can be identified by FISH (karyotype has a lower sensitivity), and the aberrant TCL1 protein expression can also be detected by flow cytometry or immunohistochemistry ( 38 ). The translocation t(X;14) is present in approximately 10–20% cases and involves the rearrangement of the TCRα locus with the proto-oncogene MTCP1 ( 39 – 41 ).…”
Section: T-prolymphocytic Leukemiamentioning
confidence: 99%