Comparison of isosorbide mononitrate and misoprostol for cervical ripening in termination of pregnancy between 8 and 12 weeks: a randomized controlled trial

Abstract

The results show that IMN has a definite role and better safety profile than misoprostol in first trimester cervical ripening, although misoprostol is more effective and causes less blood loss.

Comparative study between vaginal isosorbide mononitrate and misoprostol for induction of cervical ripening prior to surgical evacuation of first trimester embryonic demise

“…Isosorbide mononitrate. Similar findings have been shown by Duhan N et al 7 Abdominal pain was non significantly higher after administration of misoprostol in present study in contrast to significant high incidence of pain (17 patients v/s 55 patients) seen by Waleed-EIKhayat et al 8 Vital parameters showed no significant variation in our study. Arteago-Troncoso G et al 9 showed that systolic & diastolic blood pressures were lower after administration of tab.…”

Evaluation of isosorbide-5-mononitrate as a cervical ripening agent prior to induced abortion in contrast to misoprostol- a randomized controlled trial

“…Dhillon et al [21] in their study involving 25 women in each group also showed that headache was statistically higher in the ISMN group than the misoprostol group. Similar findings were also shown by Duhan et al [22]. However, this present study fails to demonstrate any significantly higher incidence of headache in the ISMN group.…”

Can isosorbide mononitrate be useful in second trimester termination of pregnancies?

“…Moreover, there can be no comparison with data from other studies since, to our knowledge, this is the first time that an effort to estimate blood loss has been reported. However, in a study about the use of IMN for first trimester termination of pregnancy, a higher blood loss was noted in the intervention group but without any clinical significance [10].…”

“…There is now data about the use of ΝΟ donors in induction of labor [8,9] and also first trimester terminations of pregnancy [2,10]. The published results are contradictory and inconclusive.…”