Comparison of isolated infection by hepatitis C (HCV) or by hepatitis B (HBV) viruses and of coinfection by HCV-HBV in 1098 renal transplant patients

Pouteil‐Noble, Claire; Maiza, Hakim; Donia, Ahmed Farouk; Mercier, S.; Chossegros, P.; Gérard, F; Mion, François; Chevallier, Philippe; Touraine, J. L.

doi:10.1016/s0041-1345(96)00103-0

Cited by 4 publications

(2 citation statements)

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“…Others have suggested that HCV and HBV have a reciprocal inhibitory effect on each other's replication. 11,30,31 A possible explanation for the absence of any impact of HBV on HCV RNA levels is that the present study did not focus on active HBV replication as measured by HBe-antigen testing and only HBc antibody-positive serum samples were analyzed.…”

Section: Discussionmentioning

confidence: 99%

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Hepatocellular carcinoma in Egyptians with and without a history of hepatitis B virus infection: association with hepatitis C virus (HCV) infection but not with (HCV) RNA level.

Yates

Hafez²,

Beld³

et al. 1999

The American Journal of Tropical Medicine and Hygiene

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Abstract. The aim of this study was to analyze the association of hepatocellular carcinoma (HCC) with hepatitis C virus (HCV) in Egypt, using hepatitis B virus (HBV) and hepatitis E virus (HEV) as virus controls. In addition, the association of HCC with HCV RNA levels among persons seropositive for HCV was analyzed. We compared 131 patients with proven HCC, 247 with bladder cancer, and 466 healthy hospital employees. Age, sex, and place of residence were recorded to study confounding factors. Among the healthy controls, 16% were seropositive for HCV, 21% for HBV, and 31% for HEV. When healthy controls were age-matched with HCC patients, the latter were significantly (P Ͻ 0.001) more often HCV seropositive (67%) than were the controls (30%). The seropositivity for HBV and HEV did not differ significantly in frequency between the two groups. The seropositivity for HCV was also significantly (P Ͻ 0.001) more often found in HCC patients (76%) than in BC patients (47%), with seroprevalences for HBV and HEV not differing significantly in these age-matched groups. In HBV-negative HCC and bladder cancer patients, seroprevalence for HCV was significantly (P ϭ 0.002) higher in HCC patients (68%) than in bladder cancer patients (36%). This difference was even more pronounced (P Ͻ 0.001) in HBV-positive HCC and bladder cancer patients (78% versus 52%, respectively). Of HCV-seropositive individuals, 49% were HCV RNA positive by branched DNA assay, and of these, 96% were infected by HCV genotype 4. No correlation between HCV RNA load and seropositivity of HBV or age or disease state was found. Infection with HCV and HCV-HBV double infection, but not HBV or HEV infection alone, is strongly correlated with HCC in Egypt.Hepatitis C virus (HCV) causes more than 90% of parenterally transmitted non-A, non-B (NANBH) hepatitis.1-4 In more than 85% of HCV infections, the infection persists and leads to chronic hepatitis. 4,5 Once chronic hepatitis is established, it may slowly progress to worsening stages of fibrosis and cirrhosis and ultimately lead to the development of hepatocellular carcinoma (HCC). 1,[6][7][8] In the first two decades after acute HCV infection, both mortality and morbidity remain modest in frequency, but after this period both can be expected to increase.1,2 Infection with HCV is widely recognized as the most common indication for liver transplantation 9 in the United States, Europe, and Japan. Although no firm data are available, death rates for HCC in Egypt appear to be increasing over the last decade. 10,11 Hepatitis virus infections of any kind are highly prevalent in the general population. The relatively high prevalence of HCV infections in Egypt was first established in 1992 by Kamel and others. 12 Other groups thereafter found HCV seroprevalence rates ranging from 6% to 38% with an average of approximately 15%. [12][13][14][15][16] The reasons behind these high HCV infection rates being 5-35-fold higher than reported elsewhere in the world are still unknown. In Egypt, the HCV seroprevalence was 55% among ...

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Section: Discussionmentioning

confidence: 99%

“…29 It has been reported that HCV and HBV have a reciprocal inhibitory effect on each other's replication levels. 11,30,31 Coinfection with HBV is believed to lead to an aggravated course of disease, and faster progression to HCC. 32,33 Alcohol abuse also may aggravate the course of HCV infection.…”

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confidence: 99%